Gene - combatTB X

Type: protein_coding
Name: ribA1
Locus Name: Rv1940
Product: Probable riboflavin biosynthesis protein RibA1 (GTP cyclohydrolase II)
Functional Category: Intermediary metabolism and respiration
Location: 2192606..2193667 (+ strand)
Gene Length: 1061 bp
Nucleotides: TGAAGACGACCGATGTGCGGGTACGTCGTGCGATCACGGCGATGGCGGGCGGTCACGCCGTGGTCCTGACCGGCGACCCCAATGGCGATGGCTATCTCGTCTTCGCCGCCCAGGCCGCGACGCCGCGGCTGGTTGCCTTTGCGGTCCGGCACACCTCGGGTTATTTGCGCGTCGCGCTGCCGGGCGCCGAATGCGAGCGACTGCACCTGCCGCCCATGTGTGACCGAGACACCACGCATTGCGTGTCGGTCGACGTTCGCGGCACCGGCACCGGAATCTCGGCGAGCGATCGCGCCTGGACCATCGCGGCACTGGCTTCGGCCACCTCCGTCGCCGCCGATTTCCAACGTCCGGGCCATGTGGTGCCCGTGCAGGCGCAAGCCGACGGTGTGCTGGGTCGGCGGGGACCCGCCGAGGCGGCCGTCGACCTGGCCCGCCTGGCGGAACGGCGGCCGGCCGCCGCGCTCTGCGAGATCGTCTCGCCCGATAATCCCGTCCAGATGGCGCACCACGCCGAGTCGGTCGAATTCGCCGTCGAACACGGACTGGCCATGGTCTCGATCGGGGAGCTGGTGGCGTATCGCCGGCGGATCGAGCCCCAGGTGGTCCGGTTTACGGCAGCGACGCTGCCCACCTGGGCCGGCGCCTCGCGTGTCATCGGCTTTCGTGACGTTTACGACCTCGGCGAGCATTTGGCGGTCATCGTGGGTGCGGTCGGTGCCGGGGTGCCCGTGCCGCTGCACGTCCACATCGAGTGCCTGACGGGCGACGTGTTCGGCTCGACGGCGTGCCGCTGCGGCGAGGAACTCAACGGCGCGCTGGCGAGGATGTCGGCTCAGGGCAGCGGCGTGGTCTTGTATCTGCGTCCGCCCGGACCCGCGCAAGCGTGCGGCTTGTTCGCCCGGGGCGATGCGGCGACCGATGTCATGCCGGAGACCGTGACATGGATCCTGCGCGATCTTGGGGTGTATGCGATCCGACTTTCCGATGATGTGCCAGGATTTGGGCTTGTCATGTTCGGGGCGATCCGAGAAGCCAGCACGTTGGCGGCCGCAGGTTGA
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Unknown

Family

DHBP synthase family

GO

metal ion binding GO:0046872 molecular_function
riboflavin biosynthetic process GO:0009231 biological_process
GTP cyclohydrolase II activity GO:0003935 molecular_function
3,4-dihydroxy-2-butanone-4-phosphate synthase activity GO:0008686 molecular_function
cytosol GO:0005829 cellular_component

InterPro

Summary

Name: Probable riboflavin biosynthesis protein RibA1 (GTP cyclohydrolase II)
Family: DHBP synthase family
Protein Sequence: MKTTDVRVRRAITAMAGGHAVVLTGDPNGDGYLVFAAQAATPRLVAFAVRHTSGYLRVALPGAECERLHLPPMCDRDTTHCVSVDVRGTGTGISASDRAWTIAALASATSVAADFQRPGHVVPVQAQADGVLGRRGPAEAAVDLARLAERRPAAALCEIVSPDNPVQMAHHAESVEFAVEHGLAMVSIGELVAYRRRIEPQVVRFTAATLPTWAGASRVIGFRDVYDLGEHLAVIVGAVGAGVPVPLHVHIECLTGDVFGSTACRCGEELNGALARMSAQGSGVVLYLRPPGPAQACGLFARGDAATDVMPETVTWILRDLGVYAIRLSDDVPGFGLVMFGAIREASTLAAAG
Mass: 36,869 Da
Length: 353 Aa

Rv1940 doesn't seem to be a targeted by any drug.

Riboflavin metabolism mtu00740
mtu00740
PATHWAY_MAP mtu00740 Riboflavin metabolism

Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.