mce3R
- Type
- protein_coding
- Name
- mce3R
- Locus Name
-
Rv1963c
- Product
-
Probable transcriptional repressor (probably TetR-family) Mce3R
- Functional Category
-
Regulatory proteins
- Location
- 2205582..2206802 (- strand)
- Gene Length
- 1220 bp
- Nucleotides
-
ATGGCATCCGTCGCCCAACCCGTTAGGCGCCGCCCAAAGGACCGGAAGAAGCAGATTTTGGATCAGGCCGTTGGACTGTTCATCGAACGTGGCTTCCATTCGGTCAAATTGGAGGACATTGCCGAGGCGGCCGGGGTGACCGCGCGCGCGTTGTATCGCCACTACGACAACAAGCAGGCGTTGCTCGCCGAAGCGATCCGAACCGGCCAGGATCAGTACCAGAGCGCGCGTCGTCTCACCGAGGGCGAGACGGAGCCGACGCCGCGGCCGTTGAACGCCGATCTGGAAGACCTGATCGCCGCGGCGGTCGCCTCTCGGGCGTTGACGGTGCTGTGGCAGCGCGAGGCCCGCTACCTCAACGAGGACGACCGCACGGCGGTCCGGCGCCGCATCAACGCGATCGTCGCCGGCATGCGTGACAGCGTGCTGCTGGAGGTGCCCGATCTGAGTCCACAGCATTCGGAGTTGCGGGCGTGGGCGGTGTCCAGCACTTTGACCAGCCTGGGCCGGCACAGCCTAAGCCTGCCGGGCGAGGAACTGAAAAAGCTTCTCTACCAGGCGTGTATGGCCGCGGCAAGGACGCCTCCCGTCTGCGAATTGCCGCCACTGCCGGCCGGTGATGCCGCACGCGACGAGGCCGACGTGCTGTTCTCCCGCTACGAGACCCTGCTGGCCGCGGGCGCGCGGCTGTTCCGTGCGCAGGGCTATCCGGCCGTCAACACCAGCGAAATCGGCAAGGGAGCCGGCATCGCGGGCCCGGGGCTGTACCGTTCGTTTTCTTCCAAACAGGCCATCCTGGACGCGCTCATCCGCCGCCTCGACGAGTGGCGCTGCCTGGAGTGCATCCGAGCGCTACGAGCGAATCAGCAAGCGGCACAACGGTTGCGCGGCCTTGTCCAAGGGCACGTTCGGATCAGCTTGGACGCTCCGGATCTGGTGGCAGTGTCGGTCACCGAACTGTCGCACGCCTCTGTCGAAGTACGCGACGGCTACCTGCGAAATCAGGGCGACCGCGAGGCCGTGTGGATCGACCTCATCGGCAAGCTGGTACCCGCGACCAGTGTCGCCCAGGGGCGACTGCTGGTCGCGGCGGCGATTAGCTTCATCGAAGACGTCGCTCGCACCTGGCATCTCACGCGCTACGCCGGAGTCGCCGACGAGATCAGTGGCCTGGCGCTGGCGATCCTGACCAGCGGGGCAGGTAACCTCTTGCGCGCATA
- Drug Resistance
- Mutations
- Function
- Mce3R represses the transcription of mce3 operon and downregulates its own expression, but does not affect the transcription of mce1, mce2 and mce4 operons. {ECO:0000269|PubMed:12368433, ECO:0000269|PubMed:18304349, ECO:0000269|PubMed:19389781}.
- Family
-
Unknown
- GO
-
- regulation of lipid metabolic process GO:0019216 biological_process
- DNA-binding transcription factor activity GO:0003700 molecular_function
- DNA binding GO:0003677 molecular_function
- negative regulation of transcription, DNA-templated GO:0045892 biological_process
- lipid catabolic process GO:0016042 biological_process
- InterPro
Summary
- Name
- Transcriptional repressor Mce3R (TetR family transcriptional regulator)
- Family
- Unknown
- Protein Sequence
-
MASVAQPVRRRPKDRKKQILDQAVGLFIERGFHSVKLEDIAEAAGVTARALYRHYDNKQALLAEAIRTGQDQYQSARRLTEGETEPTPRPLNADLEDLIAAAVASRALTVLWQREARYLNEDDRTAVRRRINAIVAGMRDSVLLEVPDLSPQHSELRAWAVSSTLTSLGRHSLSLPGEELKKLLYQACMAAARTPPVCELPPLPAGDAARDEADVLFSRYETLLAAGARLFRAQGYPAVNTSEIGKGAGIAGPGLYRSFSSKQAILDALIRRLDEWRCLECIRALRANQQAAQRLRGLVQGHVRISLDAPDLVAVSVTELSHASVEVRDGYLRNQGDREAVWIDLIGKLVPATSVAQGRLLVAAAISFIEDVARTWHLTRYAGVADEISGLALAILTSGAGNLLRA
- Mass
- 44,342 Da
- Length
- 406 Aa
Rv1963c doesn't seem to be a targeted by any drug.
Rv1963c doesn't seem to be involved in any pathway.
- Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
- Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
- Mce3R, a TetR-type transcriptional repressor, controls the expression of a regulon involved in lipid metabolism in Mycobacterium tuberculosis.
- Microbiology. 2009 Jul;155(Pt 7):2245-55. doi: 10.1099/mic.0.027086-0. Epub 2009 Apr 23.
- Study of the role of Mce3R on the transcription of mce genes of Mycobacterium tuberculosis.
- BMC Microbiol. 2008 Feb 27;8:38. doi: 10.1186/1471-2180-8-38.
- Negative transcriptional regulation of the mce3 operon in Mycobacterium tuberculosis.
- Microbiology. 2002 Oct;148(Pt 10):2997-3006. doi: 10.1099/00221287-148-10-2997.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.