fabG3
- Type
- protein_coding
- Name
- fabG3
- Locus Name
-
Rv2002
- Product
-
Possible 20-beta-hydroxysteroid dehydrogenase FabG3 (cortisone reductase) ((R)-20-hydroxysteroid dehydrogenase)
- Functional Category
-
Lipid metabolism
- Location
- 2247660..2248442 (+ strand)
- Gene Length
- 782 bp
- Nucleotides
-
TGTCTGGACGGTTGATAGGAAAGGTCGCACTTGTCAGCGGCGGGGCGCGCGGTATGGGTGCATCCCATGTGCGGGCGATGGTGGCCGAAGGCGCAAAGGTTGTGTTCGGCGACATCCTCGACGAGGAGGGCAAGGCGGTGGCCGCCGAACTGGCCGATGCGGCCCGCTACGTCCATCTCGACGTTACCCAACCCGCGCAATGGACGGCTGCGGTGGACACCGCGGTCACCGCATTCGGTGGCCTGCACGTGCTGGTCAACAACGCCGGCATTCTCAACATCGGGACGATCGAGGACTACGCCCTCACCGAATGGCAGCGCATCCTCGATGTCAACCTGACCGGAGTCTTCCTGGGCATCCGCGCTGTCGTCAAGCCAATGAAAGAGGCTGGTCGCGGCTCCATCATCAACATTTCGTCGATCGAGGGGCTGGCCGGCACGGTTGCTTGTCATGGCTATACCGCCACCAAGTTCGCCGTGCGGGGGCTGACCAAGTCCACCGCTCTCGAGTTGGGGCCCAGCGGAATTCGAGTCAACTCGATTCACCCTGGGTTGGTCAAGACGCCGATGACTGACTGGGTCCCCGAAGACATCTTCCAGACCGCGCTGGGCCGCGCGGCCGAACCCGTGGAAGTGTCCAACCTCGTCGTCTACCTGGCCAGCGATGAGTCGAGCTATTCCACCGGCGCGGAATTTGTGGTCGACGGCGGGACCGTAGCTGGCCTGGCACACAACGACTTCGGTGCCGTCGAGGTGTCCTCGCAGCCGGAATGGGTGACGTAA
- Drug Resistance
- Mutations
- Function
- Unknown
- Family
-
Short-chain dehydrogenases/reductases (SDR) family
- GO
-
- plasma membrane GO:0005886 cellular_component
- oxidation-reduction process GO:0055114 biological_process
- androstan-3-alpha,17-beta-diol dehydrogenase activity GO:0047044 molecular_function
- C21-steroid hormone metabolic process GO:0008207 biological_process
- steroid metabolic process GO:0008202 biological_process
- oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0016616 molecular_function
- InterPro
1NFF
- Name
- 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase (EC 1.1.1.53)
- Family
- Short-chain dehydrogenases/reductases (SDR) family
- Protein Sequence
-
MSGRLIGKVALVSGGARGMGASHVRAMVAEGAKVVFGDILDEEGKAVAAELADAARYVHLDVTQPAQWTAAVDTAVTAFGGLHVLVNNAGILNIGTIEDYALTEWQRILDVNLTGVFLGIRAVVKPMKEAGRGSIINISSIEGLAGTVACHGYTATKFAVRGLTKSTALELGPSGIRVNSIHPGLVKTPMTDWVPEDIFQTALGRAAEPVEVSNLVVYLASDESSYSTGAEFVVDGGTVAGLAHNDFGAVEVSSQPEWVT
- Mass
- 27,030 Da
- Length
- 260 Aa
Summary
Rv2002 doesn't seem to be a targeted by any drug.
Rv2002 doesn't seem to be involved in any pathway.
- Directed evolution approach to a structural genomics project: Rv2002 from Mycobacterium tuberculosis.
- Proc Natl Acad Sci U S A. 2003 Jan 21;100(2):455-60. doi: 10.1073/pnas.0137017100. Epub 2003 Jan 10.
- Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
- Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.