Gene - combatTB X

otsB1

Type: protein_coding
Name: otsB1
Locus Name: Rv2006
Product: Probable trehalose-6-phosphate phosphatase OtsB1 (trehalose-phosphatase) (TPP)
Functional Category: Virulence, detoxification, adaptation
Location: 2252002..2255985 (+ strand)
Gene Length: 3983 bp
Nucleotides: TGCGCTGTGGCATCGTCGTCAATGTGACCGGACCGCCGCCCACCATCGACCGGCGCTACCACGACGCTGTCATCGTCGGCCTCGACAACGTGGTCGACAAGGCCACGCGAGTGCACGCCGCGGCATGGACGAAGTTCTTGGATGACTACCTCACCCGACGACCCCAGCGGACCGGCGAAGACCATTGCCCCCTCACCCACGACGACTACCGCCGCTTCTTGGCCGGCAAACCCGACGGTGTAGCCGACTTCTTGGCCGCCCGCGGAATCAGGCTGCCGCCGGGCTCCCCGACTGATCTCACCGACGACACCGTGTACGGGCTGCAAAACCTCGAGCGCCAGACATTCCTGCAACTGTTGAACACCGGTGTCCCCGAGGGCAAGTCGATTGCCTCGTTCGCACGTCGGCTGCAGGTTGCCGGTGTCCGCGTGGCCGCCCACACCTCCCACCGTAACTACGGGCACACGCTGGATGCCACCGGCCTGGCAGAAGTGTTTGCCGTCTTTGTCGACGGCGCCGTCACCGCCGAGCTCGGGCTACCGGCCGAGCCTAACCCGGCCGGCCTGATCGAGACGGCGAAGCGGCTGGGAGCAAACCCCGGTCGCTGTGTGGTCATCGACAGCTGCCAGACCGGTCTGCGCGCCGGCCGGAACGGCGGATTCGCGCTGGTGATTGCCGTCGACGCGCACGGCGATGCCGAGAACCTGCTGTCCAGCGGAGCCGACGCCGTGGTCGCAGACCTGGCCGCTGTCACGGTGGGAAGCGGCGACGCCGCCATCTCCACGATTCCCGACGCCCTGCAGGTCTACAGCCAATTGAAAAGACTACTGACCGGCCGACGACCAGCGGTGTTTCTCGATTTCGACGGCACGTTATCCGATATCGTCGAGCGCCCCGAAGCGGCAACGCTCGTCGACGGCGCAGCAGAAGCGTTGCGAGCGCTGGCGGCCCAGTGTCCGGTGGCGGTGATAAGCGGACGCGACCTGGCCGACGTTCGCAACCGGGTCAAAGTCGACGGGCTGTGGCTGGCCGGCAGCCACGGCTTCGAATTAGTGGCGCCAGACGGCAGCCATCACCAAAACGCCGCCGCCACTGCAGCTATCGACGGATTGGCCGAGGCGGCAGCGCAATTGGCCGACGCACTCCGCGAAATCGCCGGAGCAGTAGTGGAACACAAACGCTTCGCAGTCGCAGTGCACTATCGCAACGTTGCCGACGACAGCGTCGACAACCTGATTGCGGCGGTGCGCCGACTCGGACACGCAGCAGGGCTGCGTGTCACCACCGGCCGCAAAGTCGTCGAGCTTCGCCCGGATATAGCCTGGGACAAGGGCAAAGCACTCGATTGGATCGGTGAGCGGCTCGGCCCGGCCGAAGTCGGCCCCGACCTACGGTTGCCGATCTACATCGGCGACGACCTTACCGACGAAGATGCCTTTGATGCCGTGCGTTTCACCGGTGTCGGGATTGTGGTGCGCCACAACGAACACGGTGATCGACGGTCTGCCGCTACCTTTCGTCTCGAATGTCCTTACACCGTTTGCCAATTCCTCTCCCAGCTGGCTTGCGATCTGCAGGAGGCAGTGCAGCACGACGATCCGTGGACTCTGGTCTTCCACGGCTACGACCCCGGCCAGGAGCGGCTGCGTGAAGCGCTGTGCGCGGTGGGCAACGGCTACCTGGGTTCGCGGGGCTGCGCACCCGAATCAGCGGAAAGCGAGGCACATTACCCGGGCACCTATGTGGCCGGGGTGTACAACCAGCTCACTGACCACATCGAAGGGTGCACCGTTGACAACGAAAGCCTGGTCAACCTCCCCAACTGGTTGTCGCTGACCTTCCGTATCGACGGCGGAGCATGGTTCAACGTCGATACGGTCGAGTTGTTGTCCTACCGGCAGACGTTCGACCTACGCCGTGCCACGTTGACCCGCAGCTTGCGATTCCGAGACGCCGGCGGACGAGTGACCACGATGACCCAGGAGCGGTTCGCGTCCATGAACCGGCCCAACCTGGTCGCACTGCAAACTCGGATTGAATCCGAAAATTGGTCGGGCACAGTTGATTTCCGGTCACTAGTCGACGGAGGTGTGCATAACACCCTGGTGGACCGCTATCGGCAACTATCCAGCCAACACCTTACCACCGCCGAGATAGAAGTCCTGGCGGACTCGGTGTTGTTGCGCACCCAGACGTCGCAATCGGGTATCGCGATCGCGGTCGCCGCTCGCAGTACCCTGTGGCGCGATGGCCAACGGGTCGACGCGCAATATCGGGTCGCCAGGGACACCAACCGCGGCGGCCATGACATCCAGGTCACCCTGTCAGCGGGGCAATCGGTCACGCTGGAAAAGGTCGCGACGATCTTCACGAGCCGGGACGCCGCGACATTGACAGCGGCAATAAGCGCACAGCGCTGTCTAGGTGAGGCCGGTCGCTATGCCGAGCTCTGTCAACAGCACGTCCGCGCGTGGGCACGGCTGTGGGAACGATGCGCCATCGATTTGACCGGCAACACCGAGGAATTGCGGCTCGTGCGACTGCACCTACTGCACCTGCTACAGACCATTTCGCCGCATACCGCTGAGCTCGACGCCGGGGTCCCAGCGCGCGGGCTGAACGGAGAGGCCTACCGCGGGCATGTCTTCTGGGATGCGCTGTTCGTCGCTCCGGTGCTCAGCCTGCGGATGCCGAAGGTGGCGCGATCGCTGCTGGACTATCGGTACCGACGACTACCCGCGGCCCGCCGAGCGGCGCACCGGGCGGGCCACCTTGGCGCGATGTATCCCTGGCAGTCGGGCAGCGACGGAAGCGAAGTGAGTCAGCAGCTGCACCTCAATCCACGGTCCGGGCGGTGGACTCCCGATCCCAGTGATCGTGCCCATCACGTCGGTCTAGCGGTTGCCTACAACGCGTGGCACTACTACCAAGTGACCGGTGACCGCCAGTATCTCGTCGACTGCGGGGCAGAGCTGCTGGTTGAGATCGCACGCTTCTGGGTAGGCCTGGCCAAGTTGGATGACAGTCGCGGCCGCTACCTGATCCGGGGAGTAATCGGTCCCGACGAATTCCATTCGGGGTATCCCGGCAACGAGTACGACGGAATAGACAACAATGCGTACACCAACGTGATGGCGGTATGGGTGATCCTGCGGGCAATGGAGGCGCTGGACCTGCTACCGCTGACCGATCGCCGCCATCTGATCGAAAAGCTCGGGCTGACAACGCAGGAGCGCGACCAATGGGACGACGTGAGCCGACGCATGTTCGTTCCATTCCACGACGGCGTGATCAGCCAGTTCGAGGGCTATTCGGAACTGGCGGAACTGGATTGGGATCACTATCGGCACCGATACGGAAACATCCAACGACTCGACCGGATCCTGGAAGCCGAGGGCGACAGCGTGAACAACTACCAGGCGTCCAAGCAAGCCGACGCGCTGATGCTGCTCTACCTGCTGTCTTCCGACGAGCTGATCGGCCTGTTGGCCCGGCTTGGCTACCGCTTCGCGCCCACACAAATCCCAGGCACCGTGGATTACTATCTTGCCCGCACCTCGGATGGATCTACCCTGAGCGCTGTCGTGCATGCGTGGGTTCTCGCCCGCGCCAACCGGAGCAATGCCATGGAGTACTTCCGTCAGGTCCTGCGCTCCGATATCGCCGACGTCCAGGGCGGCACAACCCAGGAAGGAATTCACCTGGCGGCCATGGCTGGCAGCATCGACCTGCTGCAGCGTTGCTATTCCGGATTGGAACTGCGCGACGACCGGCTGGTGTTGAGCCCGCAATGGCCGGAAGCACTTGGACCACTTGAGTTTCCGTTTGTGTACCGCCGCCACCAGCTGAGCCTGCGAATCAGTGGCCGAAGCGCCACATTGACCGCAGAAAGTGGAGACGCCGAGCCAATTGAGGTCGAATGCCGTGGCCACGTGCAGCGGCTACGGTGCGGGCACACCATCGAAGTCGGTTGCAGCAGGTGA
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Unknown

Family

Trehalose phosphatase family; Glycosyl hydrolase 65 family

GO

carbohydrate binding GO:0030246 molecular_function
carbohydrate metabolic process GO:0005975 biological_process
trehalose biosynthetic process GO:0005992 biological_process
cell wall GO:0005618 cellular_component
extracellular region GO:0005576 cellular_component
plasma membrane GO:0005886 cellular_component
dephosphorylation GO:0016311 biological_process
hydrolase activity, hydrolyzing O-glycosyl compounds GO:0004553 molecular_function

InterPro

UniProt: P9WN15
GenBank: Rv2006
EnsemblBacteria: Rv2006
Mycobrowser: Rv2006

Summary

Name: Uncharacterized glycosyl hydrolase Rv2006 (EC 3.2.1.-)
Family: Trehalose phosphatase family; Glycosyl hydrolase 65 family
Protein Sequence: MRCGIVVNVTGPPPTIDRRYHDAVIVGLDNVVDKATRVHAAAWTKFLDDYLTRRPQRTGEDHCPLTHDDYRRFLAGKPDGVADFLAARGIRLPPGSPTDLTDDTVYGLQNLERQTFLQLLNTGVPEGKSIASFARRLQVAGVRVAAHTSHRNYGHTLDATGLAEVFAVFVDGAVTAELGLPAEPNPAGLIETAKRLGANPGRCVVIDSCQTGLRAGRNGGFALVIAVDAHGDAENLLSSGADAVVADLAAVTVGSGDAAISTIPDALQVYSQLKRLLTGRRPAVFLDFDGTLSDIVERPEAATLVDGAAEALRALAAQCPVAVISGRDLADVRNRVKVDGLWLAGSHGFELVAPDGSHHQNAAATAAIDGLAEAAAQLADALREIAGAVVEHKRFAVAVHYRNVADDSVDNLIAAVRRLGHAAGLRVTTGRKVVELRPDIAWDKGKALDWIGERLGPAEVGPDLRLPIYIGDDLTDEDAFDAVRFTGVGIVVRHNEHGDRRSAATFRLECPYTVCQFLSQLACDLQEAVQHDDPWTLVFHGYDPGQERLREALCAVGNGYLGSRGCAPESAESEAHYPGTYVAGVYNQLTDHIEGCTVDNESLVNLPNWLSLTFRIDGGAWFNVDTVELLSYRQTFDLRRATLTRSLRFRDAGGRVTTMTQERFASMNRPNLVALQTRIESENWSGTVDFRSLVDGGVHNTLVDRYRQLSSQHLTTAEIEVLADSVLLRTQTSQSGIAIAVAARSTLWRDGQRVDAQYRVARDTNRGGHDIQVTLSAGQSVTLEKVATIFTSRDAATLTAAISAQRCLGEAGRYAELCQQHVRAWARLWERCAIDLTGNTEELRLVRLHLLHLLQTISPHTAELDAGVPARGLNGEAYRGHVFWDALFVAPVLSLRMPKVARSLLDYRYRRLPAARRAAHRAGHLGAMYPWQSGSDGSEVSQQLHLNPRSGRWTPDPSDRAHHVGLAVAYNAWHYYQVTGDRQYLVDCGAELLVEIARFWVGLAKLDDSRGRYLIRGVIGPDEFHSGYPGNEYDGIDNNAYTNVMAVWVILRAMEALDLLPLTDRRHLIEKLGLTTQERDQWDDVSRRMFVPFHDGVISQFEGYSELAELDWDHYRHRYGNIQRLDRILEAEGDSVNNYQASKQADALMLLYLLSSDELIGLLARLGYRFAPTQIPGTVDYYLARTSDGSTLSAVVHAWVLARANRSNAMEYFRQVLRSDIADVQGGTTQEGIHLAAMAGSIDLLQRCYSGLELRDDRLVLSPQWPEALGPLEFPFVYRRHQLSLRISGRSATLTAESGDAEPIEVECRGHVQRLRCGHTIEVGCSR
Mass: 145,784 Da
Length: 1327 Aa

Rv2006 doesn't seem to be a targeted by any drug.

Starch and sucrose metabolism mtu00500
mtu00500
PATHWAY_MAP mtu00500 Starch and sucrose metabolism

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The OtsAB pathway is essential for trehalose biosynthesis in Mycobacterium tuberculosis.: J Biol Chem. 2005 Apr 15;280(15):14524-9. doi: 10.1074/jbc.M414232200. Epub 2005 Feb 9.
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