Gene - combatTB X

cobN

Type: protein_coding
Name: cobN
Locus Name: Rv2062c
Product: Cobalamin biosynthesis protein CobN
Functional Category: Intermediary metabolism and respiration
Location: 2317169..2320753 (- strand)
Gene Length: 3584 bp
Nucleotides: GTGCCGGAACCGACCGTTCTGCTGTTGTCGACGTCCGACACCGACCTGATTAGCGCCCGGTCCAGCGGCAAGAACTACCGGTGGGCGAATCCCTCGCGGCTGTCTGACCTGGAACTGACCGACCTGCTGGCCGAAGCGTCGATCGTGGTGATCCGGATTCTCGGCGGCTACCGCGCCTGGCAGAGCGGAATCGACACGGTGATCGCCGGCGGGGTACCGGCCGTACTGGTCAGCGGAGAGCAGGCCGCCGATGCCGAGTTGACCGACCGCTCCACGGTCGCGGCCGGCACCGCGCTGCAGGCCCACATCTACCTGGCCCACGGCGGCGTCGACAACCTGCGCGAGTTGCACGCCTTCCTGTGCGACACCGTGCTGATGACCGGCTTCGGGTTCACGCCGCCGGTCGCCACCCCGACCTGGGGGGTGCTGGAGCGTCCGGACGCCGGCAAGACCGGCCCGACGATCGCGGTGCTCTACTACCGTGCCCAGCACCTGGCCGGCAACACCGGCTACGTCGAGGCGCTGTGCCGGGCGATCGAAGACGCCGGCGGACGCCCGCTGCCGCTCTACTGCGCGTCGCTGCGCACCGCCGAGCCGCGGCTGCTGGAAAGGCTCGGCGGCGCCGACGCCATGGTGGTCACCGTGCTGGCCGCCGGGGGAGTCAAGCCGGCCGCCGCCTCGGCCGGCGGCGACGATGACAGCTGGAACGTTGAGCACCTGGCGGCGCTGGACATCCCGATCCTGCAAGGCCTGTGTTTGACTAGCCCGCGGGATCAGTGGTGCGCCAACGACGACGGCCTGTCGCCGCTGGACGTGGCCAGCCAGGTGGCGGTGCCCGAGTTCGACGGCCGCATCATCACGGTTCCGTTCTCGTTCAAGGAGATTGACGACGACGGGCTGATCTCCTATGTGGCCGACCCGGAGCGCTGCGCCCGGGTCGCGGGCCTGGCGGTCCGGCACGCACGGCTGCGCCAGGTCGCCCCCGCCGACAAGCGGGTGGCCCTGGTCTTCTCGGCCTACCCGACCAAACACGCCCGCATCGGCAACGCGGTGGGCCTGGACACCCCGGCCAGCGCGGTGGCCTTGCTGCAAGCGATGCGGCAGCGCGGATATCGGGTGGGTGATCTGCCGGGTGTCGAATCAAACGACGGCGACGCGCTGATTCACGCGTTGATCGAATGCGGCGGACACGACCCCGACTGGCTCACCGAAGGCCAGCTGGCCGGCAACCCCATCCGGGTGTCGGCCAAGGAGTATCGGGACTGGTTCGCCACCCTGCCCGCCGAACTGACAGACGTGGTAACAGCGTACTGGGGCCCGCCACCCGGTGAGCTGTTCGTCGACCGTAGCCACGACCCGGACGGCGAGATCGTCATCGCCGCACTGCGAGCGGGCAACCTGGTGCTCATGGTTCAGCCGCCGCGCGGCTTCGGGGAGAACCCGGTGGCGATCTACCACGACCCGGACCTGCCGCCCAGCCACCACTACCTGGCCGCCTACCGCTGGCTCGATACCGGATTCTCGAACGGTTTCGGGGCGCACGCCGTGGTGCATTTGGGCAAGCACGGCAACCTGGAATGGTTGCCGGGAAAGACGCTGGGCATGTCGGCGTCCTGCGGACCCGACGCCGCGCTGGGCGATCTGCCGCTGATCTACCCGTTTCTGGTTAACGACCCCGGCGAGGGCACCCAGGCCAAGCGGCGCGCGCACGCGGTGCTAGTCGACCATTTGATTCCTCCGATGGCCCGCGCCGAAACCTACGGCGACATCGCGCGTTTGGAACAGTTGCTCGACGAGCATGCCAGCGTCGCCGCGCTGGATCCCGGCAAGCTGCCCGCCATCCGCCAGCAGATCTGGACGCTGATCCGCGCCGCCAAGATGGACCACGACCTGGGACTGACCGAACGCCCGGAAGAGGACTCGTTCGACGACATGCTGCTACACGTCGACGGCTGGCTGTGCGAGATCAAGGACGTCCAGATCCGCGACGGGCTGCACATCCTCGGGCAAAACCCAACGGGGGAGCAAGAACTCGACCTGGTGCTGGCCATCTTGCGGGCCCGCCAGCTGTTCGGCGGCGCGCACGCGATCCCCGGCCTGCGGCAGGCACTCGGCCTGGCCGAGGATGGCACCGACGAACGCGCGACAGTCGACCAGACCGAGGCGAAAGCCCGCGAACTGGTCGCGGCCCTGCAGGCCACCGGCTGGGACCCCTCCGCCGCCGACCGACTCACCGGCAACGCCGACGCCGCCGCGGTGCTGCGGTTCGCCGCCACCGAAGTGATACCCCGGTTGGCTGGCACCGCAACCGAAATCGAGCAGGTGCTAAGAGCTTTGGACGGCCGGTTCATCCCGGCCGGGCCGTCGGGGTCGCCGCTGCGCGGCCTGGTCAACGTGCTACCCACCGGGCGCAACTTCTACTCCGTGGATCCCAAGGCGGTGCCGTCCCGGCTGGCGTGGGAAGCCGGTGTGGCACTGGCCGATTCGCTGCTGGCGCGCTACCGCGATGAGCATGGGCGGTGGCCGCGGTCGGTGGGGCTGTCGGTGTGGGGCACCTCGGCGATGCGCACGGCCGGCGACGACATCGCCGAAGTGCTTGCGCTGCTGGGGGTTCGGCCGGTATGGGACGACGCCTCGCGGCGGGTCATCGACCTGGCGCCCATGCAGCCGGCCGAGCTGGGCCGCCCGCGCATCGACGTGACGGTACGGATCTCCGGCTTTTTCCGTGATGCCTTCCCGCATGTGGTGACCATGCTCGATGACGCGGTGCGGTTGGTCGCCGACCTCGACGAGGCCGCCGAGGACAACTACGTGCGCGCGCACGCCCAAGCGGATCTGGCCCACCACGGAGATCAACGGCGAGCCACCACAAGGATTTTCGGATCCAAACCGGGAACCTACGGCGCCGGGCTGCTGCAGCTGATCGACAGCCGCAGCTGGCGCGACGACGCCGACCTCGCCCAGGTGTACACCGCCTGGGGCGGATTCGCCTACGGGCGCGACCTGGATGGCCGCGAGGCGATCGACGACATGAACCGCCAGTACCGGCGTATTGCGGTGGCCGCCAAGAATACCGACACCCGTGAACACGACATCGCCGACTCCGACGACTACTTCCAGTATCACGGCGGCATGGTGGCCACCGTGCGGGCGCTCACGGGCCAAGCACCGGCCGCCTATATCGGCGACAACACCCGACCCGACGCGATCCGCACCCGCACGCTGTCGGAGGAGACCACGCGGGTGTTTCGCGCCCGCGTGGTCAATCCGAGGTGGATGGCCGCGATGCGCCGGCACGGCTACAAGGGCGCATTCGAGATGGCGGCCACCGTCGACTATCTGTTCGGTTATGACGCCACCGCCGGGGTGATGGCGGACTGGATGTACGAGCAGCTCACGCAGCGTTACGTCCTGGACGCGCAGAACCGCACGTTCATGACCGAGTCCAACCCGTGGGCGCTGCACGGCATGGCCGAACGGCTGTTGGAAGCGGCCGGTCGCGGCCTGTGGGCACAGCCGGCACCGGAAACCCTGGACGGGTTGCGCCAGGTGCTGCTGGAAACCGAGGGCGACCTGGAAGCCTG
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Unknown

Family

Unknown

GO

cobalamin biosynthetic process GO:0009236 biological_process
cytosol GO:0005829 cellular_component
plasma membrane GO:0005886 cellular_component
cobaltochelatase activity GO:0051116 molecular_function

InterPro

UniProt: O53498
GenBank: Rv2062c
EnsemblBacteria: Rv2062c
Mycobrowser: Rv2062c

Summary

Name: Cobalamin biosynthesis protein CobN
Family: Unknown
Protein Sequence: MPEPTVLLLSTSDTDLISARSSGKNYRWANPSRLSDLELTDLLAEASIVVIRILGGYRAWQSGIDTVIAGGVPAVLVSGEQAADAELTDRSTVAAGTALQAHIYLAHGGVDNLRELHAFLCDTVLMTGFGFTPPVATPTWGVLERPDAGKTGPTIAVLYYRAQHLAGNTGYVEALCRAIEDAGGRPLPLYCASLRTAEPRLLERLGGADAMVVTVLAAGGVKPAAASAGGDDDSWNVEHLAALDIPILQGLCLTSPRDQWCANDDGLSPLDVASQVAVPEFDGRIITVPFSFKEIDDDGLISYVADPERCARVAGLAVRHARLRQVAPADKRVALVFSAYPTKHARIGNAVGLDTPASAVALLQAMRQRGYRVGDLPGVESNDGDALIHALIECGGHDPDWLTEGQLAGNPIRVSAKEYRDWFATLPAELTDVVTAYWGPPPGELFVDRSHDPDGEIVIAALRAGNLVLMVQPPRGFGENPVAIYHDPDLPPSHHYLAAYRWLDTGFSNGFGAHAVVHLGKHGNLEWLPGKTLGMSASCGPDAALGDLPLIYPFLVNDPGEGTQAKRRAHAVLVDHLIPPMARAETYGDIARLEQLLDEHASVAALDPGKLPAIRQQIWTLIRAAKMDHDLGLTERPEEDSFDDMLLHVDGWLCEIKDVQIRDGLHILGQNPTGEQELDLVLAILRARQLFGGAHAIPGLRQALGLAEDGTDERATVDQTEAKARELVAALQATGWDPSAADRLTGNADAAAVLRFAATEVIPRLAGTATEIEQVLRALDGRFIPAGPSGSPLRGLVNVLPTGRNFYSVDPKAVPSRLAWEAGVALADSLLARYRDEHGRWPRSVGLSVWGTSAMRTAGDDIAEVLALLGVRPVWDDASRRVIDLAPMQPAELGRPRIDVTVRISGFFRDAFPHVVTMLDDAVRLVADLDEAAEDNYVRAHAQADLAHHGDQRRATTRIFGSKPGTYGAGLLQLIDSRSWRDDADLAQVYTAWGGFAYGRDLDGREAIDDMNRQYRRIAVAAKNTDTREHDIADSDDYFQYHGGMVATVRALTGQAPAAYIGDNTRPDAIRTRTLSEETTRVFRARVVNPRWMAAMRRHGYKGAFEMAATVDYLFGYDATAGVMADWMYEQLTQRYVLDAQNRTFMTESNPWALHGMAERLLEAAGRGLWAQPAPETLDGLRQVLLETEGDLEA
Mass: 129,210 Da
Length: 1194 Aa

Rv2062c doesn't seem to be a targeted by any drug.

Porphyrin and chlorophyll metabolism mtu00860
mtu00860
PATHWAY_MAP mtu00860 Porphyrin and chlorophyll metabolism

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.