cobI
- Type
- protein_coding
- Name
- cobI
- Locus Name
-
Rv2066
- Product
-
Probable bifunctional protein, CobI-COBJ fusion protein: S-adenosyl-L-methionine-precorrin-2 methyl transferase + precorrin-3 methylase
- Functional Category
-
Intermediary metabolism and respiration
- Location
- 2323175..2324701 (+ strand)
- Gene Length
- 1526 bp
- Nucleotides
-
TGAGCGCTCGGGGCACGCTGTGGGGAGTCGGGCTGGGGCCCGGCGATCCGGAGTTGGTGACCGTCAAGGCCGCCCGGGTGATTGGCGAGGCCGATGTGGTGGCCTATCACAGCGCCCCACACGGTCACAGCATCGCCCGCGGCATCGCCGAACCGTATCTGCGGCCCGGTCAGCTCGAGGAGCACCTGGTCTACCCGGTGACCACCGAGGCCACGAATCATCCCGGCGGCTACGCCGGTGCGCTCGAAGACTTCTACGCCGACGCGACCGAGCGCATCGCCACGCACCTGGACGCCGGGCGCAACGTGGCGCTGCTCGCCGAAGGCGACCCGTTGTTCTACAGCTCCTACATGCATCTGCACACCCGGCTGACGCGGCGGTTCAACGCCGTCATCGTGCCCGGTGTGACGTCGGTGAGCGCCGCGTCGGCGGCCGTGGCCACACCGCTGGTGGCCGGCGACCAGGTGTTGTCGGTGCTGCCGGGCACGCTGCCGGTCGGCGAGCTGACCCGCCGGCTGGCCGACGCCGACGCGGCCGTGGTGGTCAAGCTGGGCCGTTCGTATCACAATGTGCGGGAGGCGCTTTCGGCGTCCGGCCTACTCGGCGACGCGTTCTACGTGGAGCGGGCCAGCACCGCCGGCCAACGGGTATTGCCGGCCGCCGACGTCGACGAGACCAGCGTGCCGTACTTCTCGCTGGCCATGTTGCCGGGCGGGCGGCGTCGTGCGTTGCTGACCGGCACCGTCGCAGTGGTGGGCCTGGGGCCCGGCGACAGCGACTGGATGACACCGCAGAGCCGGCGTGAGCTGGCCGCCGCGACGGATCTGATCGGCTATCGCGGCTACCTGGACCGGGTCGAAGTCCGCGACGGCCAGCGGCGCCATCCCAGCGACAACACCGACGAACCCGCCCGGGCGCGGCTGGCCTGCTCGCTGGCCGATCAGGGCCGGGCGGTGGCGGTGGTGTCCTCCGGCGACCCAGGGGTATTCGCGATGGCCACCGCCGTTTTGGAGGAAGCCGAGCAGTGGCCGGGGGTGCGGGTCCGGGTGATTCCGGCGATGACCGCCGCCCAGGCCGTCGCCAGCCGGGTCGGCGCGCCGCTGGGACATGACTACGCGGTGATCTCGTTGTCCGACCGGCTCAAACCCTGGGACGTGATCGCCGCGCGCCTGACCGCCGCGGCCGCCGCCGACCTGGTGCTGGCCATCTACAACCCGGCTTCGGTGACCCGCACCTGGCAGGTCGGCGCGATGCGCGAGCTGCTGCTGGCCCATCGCGACCCTGGCATACCGGTGGTGATCGGCCGCAACGTCTCCGGACCGGTTTCCGGACCGAATGAGGACGTTCGGGTGGTGAAGTTGGCCGACCTGAACCCCGCCGAAATCGACATGCGCTGCCTATTGATCGTGGGGTCCTCGCAGACCCGGTGGTATTCGGTGGATTCGCAGGACCGGGTGTTCACCCCGCGCCGCTATCCCGAGGCGGGCAGAGCTACCGCGACAAAGTCGAGCCGCCACAGCGACTGA
- Drug Resistance
- Mutations
- Function
- Methylates precorrin-2 at the C-20 position to produce precorrin-3A. {ECO:0000250}.
- Family
-
Precorrin methyltransferase family
- GO
-
- cobalamin biosynthetic process GO:0009236 biological_process
- plasma membrane GO:0005886 cellular_component
- precorrin-2 C20-methyltransferase activity GO:0030788 molecular_function
- oxidation-reduction process GO:0055114 biological_process
- precorrin-3B C17-methyltransferase activity GO:0030789 molecular_function
- InterPro
Summary
- Name
- Cobalamin biosynthesis protein CobIJ [Includes: Precorrin-2 C(20)-methyltransferase (EC 2.1.1.130) (S-adenosyl-L-methionine--precorrin-2 methyltransferase) (SP2MT); Precorrin-3B C17-methyltransferase (EC 2.1.1.131) (S-adenosyl-L-methionine--precorrin-3B methyltransferase)]
- Family
- Precorrin methyltransferase family
- Protein Sequence
-
MSARGTLWGVGLGPGDPELVTVKAARVIGEADVVAYHSAPHGHSIARGIAEPYLRPGQLEEHLVYPVTTEATNHPGGYAGALEDFYADATERIATHLDAGRNVALLAEGDPLFYSSYMHLHTRLTRRFNAVIVPGVTSVSAASAAVATPLVAGDQVLSVLPGTLPVGELTRRLADADAAVVVKLGRSYHNVREALSASGLLGDAFYVERASTAGQRVLPAADVDETSVPYFSLAMLPGGRRRALLTGTVAVVGLGPGDSDWMTPQSRRELAAATDLIGYRGYLDRVEVRDGQRRHPSDNTDEPARARLACSLADQGRAVAVVSSGDPGVFAMATAVLEEAEQWPGVRVRVIPAMTAAQAVASRVGAPLGHDYAVISLSDRLKPWDVIAARLTAAAAADLVLAIYNPASVTRTWQVGAMRELLLAHRDPGIPVVIGRNVSGPVSGPNEDVRVVKLADLNPAEIDMRCLLIVGSSQTRWYSVDSQDRVFTPRRYPEAGRATATKSSRHSD
- Mass
- 53,911 Da
- Length
- 508 Aa
Rv2066 doesn't seem to be a targeted by any drug.
-
-
Porphyrin and chlorophyll metabolism mtu00860
mtu00860PATHWAY_MAP mtu00860 Porphyrin and chlorophyll metabolism
-
- Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
- Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.