cobM
- Type
- protein_coding
- Name
- cobM
- Locus Name
-
Rv2071c
- Product
-
Precorrin-3 methylase CobM (precorrin-4 C11-methyltransferase)
- Functional Category
-
Intermediary metabolism and respiration
- Location
- 2328222..2328977 (- strand)
- Gene Length
- 755 bp
- Nucleotides
-
ATGACGGTCTATTTCATCGGAGCGGGCCCCGGCGCCGCCGACCTAATCACCGTCCGCGGCCAACGGCTCCTGCAACGATGCCCGGTGTGCCTGTATGCGGGTTCGATCATGCCCGACGACCTGTTGGCGCAGTGTCCGCCCGGCGCGACGATTGTCGACACCGGTCCGCTGACCCTCGAACAAATCGTGCGCAAACTTGCCGACGCCGACGCCGACGGCCGCGACGTTGCCCGGCTGCATTCCGGCGACCCGTCGCTGTACAGCGCGCTGGCCGAACAGTGCCGCGAACTCGACGCGCTGGGCATCGGCTACGAAATCGTGCCGGGCGTACCGGCTTTTGCCGCAGCCGCGGCGGCGCTAAAGCGCGAACTCACCGTGCCGGGCGTGGCGCAGACGGTGACGCTCACCCGGGTGGCGACGCTGTCCACACCCATACCGCCCGGTGAGGACCTGGCCGCGCTCGCCCGATCCCGCGCCACTCTGGTCTTGCACCTGGCCGCAGCCCAGATCGACGCCATCGTTCCGCGACTGCTAGACGGTGGTTACCGACCCGAAACGCCGGTTGCGGTGGTGGCTTTCGCGAGTTGGCCGCAACAGCGGACGCTACGCGGCACGTTGGCCGATATCGCCGCGCGGATGCACGATGCCAAGATCACCAGGACCGCCGTGATCGTTGTTGGCGACGTGCTGACCGCTGAGGGCTTTACCGACAGCTACCTATATTCGGTGGCACGGCACGGTCGGTATGCACAGTG
- Drug Resistance
- Mutations
- Function
- Catalyzes the methylation of C-11 in precorrin-4 to form precorrin-5. {ECO:0000250}.
- Family
-
Precorrin methyltransferase family
- GO
-
- precorrin-4 C11-methyltransferase activity GO:0046026 molecular_function
- cobalamin biosynthetic process GO:0009236 biological_process
- oxidation-reduction process GO:0055114 biological_process
- InterPro
Summary
- Name
- Precorrin-4 C(11)-methyltransferase (EC 2.1.1.133) (Precorrin-3 methylase)
- Family
- Precorrin methyltransferase family
- Protein Sequence
-
MTVYFIGAGPGAADLITVRGQRLLQRCPVCLYAGSIMPDDLLAQCPPGATIVDTGPLTLEQIVRKLADADADGRDVARLHSGDPSLYSALAEQCRELDALGIGYEIVPGVPAFAAAAAALKRELTVPGVAQTVTLTRVATLSTPIPPGEDLAALARSRATLVLHLAAAQIDAIVPRLLDGGYRPETPVAVVAFASWPQQRTLRGTLADIAARMHDAKITRTAVIVVGDVLTAEGFTDSYLYSVARHGRYAQ
- Mass
- 26,420 Da
- Length
- 251 Aa
Rv2071c doesn't seem to be a targeted by any drug.
-
-
Porphyrin and chlorophyll metabolism mtu00860
mtu00860PATHWAY_MAP mtu00860 Porphyrin and chlorophyll metabolism
-
- Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
- Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.