pknJ
- Type
- protein_coding
- Name
- pknJ
- Locus Name
-
Rv2088
- Product
-
Transmembrane serine/threonine-protein kinase J PknJ (protein kinase J) (STPK J)
- Functional Category
-
Regulatory proteins
- Location
- 2344411..2346180 (+ strand)
- Gene Length
- 1769 bp
- Nucleotides
-
TGGCCCACGAGTTGAGTGCGGGTTCGGTTTTTGCCGGGTACCGGATAGAGCGGATGCTAGGTGCCGGCGGAATGGGCACCGTATATCTGGCGCGTAATCCCGATCTGCCGCGTAGCGAAGCCTTGAAAGTCCTTGCTGCGGAGTTGTCGCGTGACCTCGATTTTCGGGCACGGTTTGTCCGCGAAGCCGATGTGGCCGCGGGGTTGGATCATCCCAACATCGTGGCGGTTCATCAGCGCGGCCAGTTCGAGGGTCGGCTATGGATTGCGATGCAGTTCGTCGATGGCGGGAACGCTGAGGATGCGCTGCGGGCGGCGACCATGACCACAGCGCGGGCGGTGTACGTGATCGGCGAGGTCGCCAAGGCGCTCGACTATGCGCACCAACAAGGCGTGATACATCGCGATATCAAGCCGGCGAACTTCTTGTTGTCGCGAGCCGCTGGCGGCGATGAACGAGTGCTGCTAAGCGATTTTGGGATCGCGCGTGCGCTCGGCGACACGGGACTGACGTCCACCGGTTCGGTGCTGGCCACGTTGGCCTATGCTGCGCCGGAAGTTCTTGCAGGGCAAGGTTTTGATGGCCGGGCCGATTTGTATTCGTTGGGGTGTGCCCTATTTCGGCTCCTAACCGGTGAGGCGCCGTTTGCCGCCGGTGCTGGAGCGGCGGTGGCAGTGGTGGCGGGTCATCTGCACCAACCGCCGCCGACGGTCAGCGATCGCGTGCCAGGGCTGTCGGCGGCGATGGATGCGGTGATCGCCACTGCGATGGCCAAGGATCCCATGCGTCGGTTCACCTCAGCGGGTGAATTCGCACATGCCGCCGCCGCAGCCCTGTACGGGGGAGCCACCGACGGATGGGTGCCGCCGAGCCCCGCGCCGCACGTCATATCGCAAGGCGCCGTGCCAGGTTCGCCGTGGTGGCAGCATCCGGTCGGGTCAGTGACCGCGTTGGCCACGCCGCCCGGTCACGGTTGGCCGCCAGGCCTGCCGCCGCTGCCGAGACGACCGCGCCGCTACCGTCGGGGCGTGGCGGCGGTGGCGGCCGTGATGGTGGTGGCCGCCGCGGCCGTCACCGCGGTGACCATGACATCGCACCAACCGCGGACCGCGACGCCGCCAAGCGCTGCAGCCCTTTCTCCCACCTCGTCCAGCACAACACCACCGCAACCACCGATCGTGACAAGGTCGCGCCTACCCGGGTTGTTGCCGCCCCTTGATGACGTCAAAAACTTCGTGGGCATCCAGAACCTGGTCGCCCATGAGCCAATGCTTCAACCCCAGACTCCCAACGGGTCAATCAACCCCGCGGAGTGCTGGCCGGCGGTTGGGGGTGGCGTTCCTAGCGCCTACGACCTGGGGACCGTCATCGGCTTTTACGGGTTGACAATCGACGAGCCGCCCACCGGGACTGCCCCAAATCAAGTGGGGCAACTGATCGTGGCCTTTCGCGACGCGGCCACAGCCCAAAGGCATTTGGCCGATTTGGCGTCGATCTGGCGCCGATGCGGGGGTCGAACCGTAACACTCTTCCGTAGTGAGTGGCGAAGGCCCGTTGAACTGTCGACGAGCGTTCCCGAAGTCGTTGATGGCATCACCACCATGGTGTTGACGGCGCAGGGACCGGTGCTACGAGTCCGCGAAGACCATGCGATCGCCGCGAAGAATAATGTGCTTGTCGATGTCGACATCATGACGCCCGACACCAGCCGCGGCCAGCAGGCGGTCATCGGCATCACCAACTACATCCTCGCCAAGATACCCGGCTGA
- Drug Resistance
- Mutations
- Function
- In vitro, phosphorylates various substrates such as EmbR, PepE, MmaA4, Pyk, LldD and GroEL2. {ECO:0000269|PubMed:20185505, ECO:0000269|PubMed:20520732}.
- Family
-
Protein kinase superfamily, Ser/Thr protein kinase family
- GO
-
- protein autophosphorylation GO:0046777 biological_process
- ATP binding GO:0005524 molecular_function
- plasma membrane GO:0005886 cellular_component
- cobalt ion binding GO:0050897 molecular_function
- nickel cation binding GO:0016151 molecular_function
- energy homeostasis GO:0097009 biological_process
- protein serine/threonine kinase activity GO:0004674 molecular_function
- integral component of membrane GO:0016021 cellular_component
- InterPro
Summary
- Name
- Serine/threonine-protein kinase PknJ (EC 2.7.11.1)
- Family
- Protein kinase superfamily, Ser/Thr protein kinase family
- Protein Sequence
-
MAHELSAGSVFAGYRIERMLGAGGMGTVYLARNPDLPRSEALKVLAAELSRDLDFRARFVREADVAAGLDHPNIVAVHQRGQFEGRLWIAMQFVDGGNAEDALRAATMTTARAVYVIGEVAKALDYAHQQGVIHRDIKPANFLLSRAAGGDERVLLSDFGIARALGDTGLTSTGSVLATLAYAAPEVLAGQGFDGRADLYSLGCALFRLLTGEAPFAAGAGAAVAVVAGHLHQPPPTVSDRVPGLSAAMDAVIATAMAKDPMRRFTSAGEFAHAAAAALYGGATDGWVPPSPAPHVISQGAVPGSPWWQHPVGSVTALATPPGHGWPPGLPPLPRRPRRYRRGVAAVAAVMVVAAAAVTAVTMTSHQPRTATPPSAAALSPTSSSTTPPQPPIVTRSRLPGLLPPLDDVKNFVGIQNLVAHEPMLQPQTPNGSINPAECWPAVGGGVPSAYDLGTVIGFYGLTIDEPPTGTAPNQVGQLIVAFRDAATAQRHLADLASIWRRCGGRTVTLFRSEWRRPVELSTSVPEVVDGITTMVLTAQGPVLRVREDHAIAAKNNVLVDVDIMTPDTSRGQQAVIGITNYILAKIPG
- Mass
- 61,595 Da
- Length
- 589 Aa
Rv2088 doesn't seem to be a targeted by any drug.
Rv2088 doesn't seem to be involved in any pathway.
- Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
- Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
- Understanding the role of PknJ in Mycobacterium tuberculosis: biochemical characterization and identification of novel substrate pyruvate kinase A.
- PLoS One. 2010 May 24;5(5):e10772. doi: 10.1371/journal.pone.0010772.
- Functional characterization of the Mycobacterium tuberculosis serine/threonine kinase PknJ.
- Microbiology. 2010 Jun;156(Pt 6):1619-31. doi: 10.1099/mic.0.038133-0. Epub 2010 Feb 25.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.