Gene - combatTB X

Rv2090

Type: protein_coding
Name: Rv2090
Locus Name: Rv2090
Product: Probable 5'-3' exonuclease
Functional Category: Information pathways
Location: 2347373..2348554 (+ strand)
Gene Length: 1181 bp
Nucleotides: TGCCCGCACCCGATCCGATGCGTGGCGACCCGCCGCACCCGGCTCCGCCGCGCTTGCGATCGCCACTGGACCCAACAAGTGGCGACCCGCTGCACCCGGCTCCGCCGCGCTTGCGATCGCCACTGGACCCAACAAGTGGCGACCCGCTGCACCCGGCTCCGCCGCGCTTGCGATCGCCACTGGACCCAACAAGTGGCGACCCGCTGCACCCGGCTCCGCCGCGCTTGCGATCGCCACTGGTGCTACTGGACGGCGCCAGCATGTGGTTCCGCTCGTTCTTCGGTGTGCCATCATCGATCACCGCTCCGGATGGCCGGCCGGTCAACGCCGTACGCGGCTTCATCGACTCCATGGCGGTGGTGATCACACAGCAGCGGCCAAACCGGCTGGCGGTCTGCCTCGACTTGGATTGGCGCCCGCAGTTCCGGGTGGACCTGATCCCGTCATACAAGGCACACCGGGTGGCTGAGCCTGAGCCCAACGGCCAGCCCGACGTCGAGGAGGTGCCCGACGAGCTGACCCCGCAGGTCGACATGATCATGGAGTTACTGGACGCGTTCGGGATCGCGATGGCAGGCGCCCCGGGATTCGAAGCCGACGACGTGCTGGGCACGCTGGCAACCCGGGAGCGCCGCGACCCGGTAATCGTGGTCAGCGGAGACCGCGACCTGCTGCAAGTGGTCGCCGACGATCCGGTCCCGGTCCGGGTGCTCTACCTGGGCCGCGGCCTTGCCAAGGCCACCTTGTTCGGACCGGCCGAGGTCGCCGAGCGCTACGGGTTGCCGGCACATCGCGCCGGCGCGGCCTACGCCGAACTCGCGCTGCTGCGTGGCGATCCGTCCGACGGCCTACCCGGCGTGCCAGGCGTCGGCGAGAAGACCGCCGCTACCCTACTGGCCCGACACGGCTCGCTAGATCAGATCATGGCGGCCGCCGACGACCGCAAGACCACGATGGCCAAGGGCCTACGTACCAAACTGCTTGCCGCGTCGGCCTACATCAAGGCCGCCGACCGGGTGGTGCGGGTCGCCACCGACGCACCGGTCACGCTGTCGACACCCACCGACAGGTTCCCGCTGGTCGCAGCTGACCCGGAGCGCACCGCCGAGCTGGCGACCCGATTCGGGGTTGAATCCTCGATCGCGCGACTACAAAAAGCGCTCGACACGCTGCCCGGATGA
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

5'-3' exonuclease acting preferentially on double-stranded DNA. {ECO:0000250}.

Family

Unknown

GO

exonuclease activity GO:0004527 molecular_function
DNA binding GO:0003677 molecular_function
cell wall GO:0005618 cellular_component
5'-flap endonuclease activity GO:0017108 molecular_function
DNA replication, Okazaki fragment processing GO:0033567 biological_process

InterPro

UniProt: P9WNU3
GenBank: Rv2090
EnsemblBacteria: Rv2090
Mycobrowser: Rv2090

Summary

Name: 5'-3' exonuclease (EC 3.1.11.-)
Family: Unknown
Protein Sequence: MRSPLVLLDGASMWFRSFFGVPSSITAPDGRPVNAVRGFIDSMAVVITQQRPNRLAVCLDLDWRPQFRVDLIPSYKAHRVAEPEPNGQPDVEEVPDELTPQVDMIMELLDAFGIAMAGAPGFEADDVLGTLATRERRDPVIVVSGDRDLLQVVADDPVPVRVLYLGRGLAKATLFGPAEVAERYGLPAHRAGAAYAELALLRGDPSDGLPGVPGVGEKTAATLLARHGSLDQIMAAADDRKTTMAKGLRTKLLAASAYIKAADRVVRVATDAPVTLSTPTDRFPLVAADPERTAELATRFGVESSIARLQKALDTLPG
Mass: 34,023 Da
Length: 318 Aa

Rv2090 doesn't seem to be a targeted by any drug.

Rv2090 doesn't seem to be involved in any pathway.

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.