Gene - combatTB X

tatC

Type: protein_coding
Name: tatC
Locus Name: Rv2093c
Product: Sec-independent protein translocase transmembrane protein TatC
Functional Category: Cell wall and cell processes
Location: 2352103..2353029 (- strand)
Gene Length: 926 bp
Nucleotides: GTGCGCGCCGCCGGTCTTCTCAAACGGCTCAACCCACGTAACAGGCGCAGCCGCGTCAATCCTGACGCGACGATGTCGCTGGTCGACCACCTGACCGAGTTACGCACCAGGTTGCTGATCTCCCTGGCCGCGATCTTGGTCACCACAATCTTCGGGTTCGTCTGGTATTCGCATTCGATTTTCGGGTTGGACAGCCTCGGAGAGTGGCTGCGGCATCCCTACTGTGCCCTGCCGCAGTCGGCCCGGGCGGATATCAGCGCCGACGGAGAGTGCCGTTTGTTGGCCACCGCGCCGTTCGACCAGTTCATGTTGCGGCTCAAGGTCGGGATGGCCGCCGGCATTGTGCTGGCTTGCCCGGTGTGGTTCTACCAGCTGTGGGCGTTCATCACGCCTGGTCTCTACCAGAGGGAGCGCCGCTTCGCGGTGGCCTTCGTGATCCCAGCAGCGGTGCTGTTCGTCGCCGGTGCCGTACTGGCCTACCTGGTGTTGTCCAAGGCGTTGGGCTTTTTGTTGACCGTCGGCAGCGACGTGCAGGTGACCGCGCTGTCTGGCGACCGCTACTTTGGCTTTCTGCTCAACCTGCTGGTGGTGTTCGGGGTCAGCTTCGAATTCCCCCTGCTGATCGTGATGCTGAACCTGGCGGGCCTGCTGACCTATGAGCGGCTCAAGTCTTGGCGGCGCGGGTTGATCTTTGCGATGTTCGTCTTCGCGGCGATCTTCACGCCCGGATCCGATCCGTTCTCGATGACCGCGCTCGGTGCGGCGTTGACCGTGCTGCTAGAGCTCGCCATTCAGATCGCCCGCGTGCATGACAAGCGAAAAGCCAAGCGCGAAGCCGCGATTCCCGACGACGAAGCTTCGGTCATCGACCCGCCCTCGCCGGTGCCGGCGCCATCGGTCATCGGATCTCATGACGACGTCACGTA
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides. {ECO:0000255|HAMAP-Rule:MF_00902}.

Family

TatC family

GO

proton motive force dependent protein transmembrane transporter activity GO:0009977 molecular_function
cytosol GO:0005829 cellular_component
integral component of plasma membrane GO:0005887 cellular_component
TAT protein transport complex GO:0033281 cellular_component
intracellular protein transmembrane transport GO:0065002 biological_process
protein transport by the Tat complex GO:0043953 biological_process

InterPro

UniProt: P9WG97
GenBank: Rv2093c
EnsemblBacteria: Rv2093c
Mycobrowser: Rv2093c

Summary

Name: Sec-independent protein translocase protein TatC
Family: TatC family
Protein Sequence: MRAAGLLKRLNPRNRRSRVNPDATMSLVDHLTELRTRLLISLAAILVTTIFGFVWYSHSIFGLDSLGEWLRHPYCALPQSARADISADGECRLLATAPFDQFMLRLKVGMAAGIVLACPVWFYQLWAFITPGLYQRERRFAVAFVIPAAVLFVAGAVLAYLVLSKALGFLLTVGSDVQVTALSGDRYFGFLLNLLVVFGVSFEFPLLIVMLNLAGLLTYERLKSWRRGLIFAMFVFAAIFTPGSDPFSMTALGAALTVLLELAIQIARVHDKRKAKREAAIPDDEASVIDPPSPVPAPSVIGSHDDVT
Mass: 33,855 Da
Length: 308 Aa

Rv2093c doesn't seem to be a targeted by any drug.

Bacterial secretion system mtu03070
mtu03070
Environmental Information Processing; Membrane transport

Protein export mtu03060
mtu03060
Genetic Information Processing; Folding, sorting and degradation

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Inactivation of Rv2525c, a substrate of the twin arginine translocation (Tat) system of Mycobacterium tuberculosis, increases beta-lactam susceptibility and virulence.: J Bacteriol. 2006 Sep;188(18):6669-79. doi: 10.1128/JB.00631-06.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.