Gene - combatTB X

pafC

Type: protein_coding
Name: pafC
Locus Name: Rv2095c
Product: Proteasome accessory factor C PafC
Functional Category: Intermediary metabolism and respiration
Location: 2353365..2354315 (- strand)
Gene Length: 950 bp
Nucleotides: ATGAGCGCCCTGTCCACCCGGCTGGTGCGGCTGCTCAACATGGTGCCGTACTTCCAGGCCAACCCCCGGATCACCCGCGCCGAGGCCGCCGCCGAGCTGGGTGTCACCGCCAAGCAGCTGGAGGAGGACCTCAACCAGCTGTGGATGTGCGGCCTTCCGGGCTATTCCCCGGGTGACCTCATCGACTTCGAATTCTGCGGTGACACCATCGAGGTGACGTTCTCGGCGGGCATCGACCGGCCGTTAAAGCTCACATCGCCGGAGGCCACCGGGCTGCTGGTGGCGTTGCGGGCGCTAGCGGACATTCCCGGCGTGGTTGACCCGCAGGCGGCGCGCAGCGCCATCGCCAAGATCGCCGCCGCGGCCGGCGCGGTGGCCGCCGTTGCCGAACAGGCACCCACAGAAAGCCCGGCCGCCGCGGCCGTACGGGCCGCGGTGCGGAACAGTCGGGCGCTGACCATCGACTATTACGCCGCGTCGCATGACACCCTCACCACTCGGATCGTGGATCCCATCCGGGTGCTGTTGATCGGCGGGCACAGCTATTTGGAGGCCTGGTCGCGTGAGGCCGAAGGGGTTCGCCTGTTCCGTTTCGACCGGATTGTCGATGCCGCCGAGTTGGGCGAGCCCGCGGTTCCGCCGGAATCGGCACGGCAGGCGCCACCGGACACGTCGCTGTTCGACGGTGACCTATCGCTGCCGTCGGCGACGTTGCGGGTGGCACCGTCGGCCTCGTGGATGCTGGAGTACTACCCGATTCGGGAGCTACGACAGCTGCCGGACGGCTCCTGTGAGGTGGCCATGACCTACGCCTCTGAGGATTGGATGACGCGCCTATTGCTGGGCTTCGGTTCGGACGTGCGCGTTCTGGCGCCGGAGTCGCTCGCTCAGCGGGTTCGCGACGCCGCGACGGCCGCGCTGGATGCATACCAGGCAGCTGCGCCGCCGTG
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Part of the pafABC operon, but PafC does not seem to be involved in pupylation or substrate degradation. Appears to play at least a small role in resistance to reactive nitrogen intermediates (RNI) in vitro. {ECO:0000269|PubMed:17277063}.

Family

PafC family

GO

cell wall GO:0005618 cellular_component

InterPro

UniProt: P9WIL9
GenBank: Rv2095c
EnsemblBacteria: Rv2095c
Mycobrowser: Rv2095c

Summary

Name: Protein PafC (Proteasome accessory factor C)
Family: PafC family
Protein Sequence: MSALSTRLVRLLNMVPYFQANPRITRAEAAAELGVTAKQLEEDLNQLWMCGLPGYSPGDLIDFEFCGDTIEVTFSAGIDRPLKLTSPEATGLLVALRALADIPGVVDPQAARSAIAKIAAAAGAVAAVAEQAPTESPAAAAVRAAVRNSRALTIDYYAASHDTLTTRIVDPIRVLLIGGHSYLEAWSREAEGVRLFRFDRIVDAAELGEPAVPPESARQAPPDTSLFDGDLSLPSATLRVAPSASWMLEYYPIRELRQLPDGSCEVAMTYASEDWMTRLLLGFGSDVRVLAPESLAQRVRDAATAALDAYQAAAPP
Mass: 33,764 Da
Length: 316 Aa

Rv2095c doesn't seem to be a targeted by any drug.

Rv2095c doesn't seem to be involved in any pathway.

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.
Characterization of the proteasome accessory factor (paf) operon in Mycobacterium tuberculosis.: J Bacteriol. 2007 Apr;189(8):3044-50. doi: 10.1128/JB.01597-06. Epub 2007 Feb 2.