Gene - combatTB X

pafB

Type: protein_coding
Name: pafB
Locus Name: Rv2096c
Product: Proteasome accessory factor B PafB
Functional Category: Intermediary metabolism and respiration
Location: 2354312..2355310 (- strand)
Gene Length: 998 bp
Nucleotides: ATGGCGACCTCGAAAGTCGAACGGCTGGTCAATCTCGTCATAGCCTTGCTGTCCACTCGTGGCTACATCACTGCGGAGAAGATCAGGTCCAGCGTGGCAGGCTATTCGGACAGCCCCAGCGTTGAGGCGTTCTCCCGGATGTTCGAGCGCGACAAGAACGAGCTGCGTGACCTCGGCATTCCGCTCGAGGTCGGCAGGGTCTCGGCGTTGGAGCCCACCGAGGGCTATCGCATCAACCGCGACGCCTACGCCCTGTCGCCTGTCGAGCTGACCCCGGATGAGGCGGCCGCGGTAGCCGTCGCCACCCAGCTGTGGGAGTCACCGGAGTTGATCACCGCGACCCAGGGCGCGTTGCTGAAGCTGCGGGCCGCCGGGGTGGACGTCGATCCCTTGGATACCGGGGCACCGGTGGCCATCGCGTCGGCGGCGGCCGTTTCGGGACTGCGCGGCTCTGAGGACGTTCTCGGAATCTTGTTGTCGGCCATCGATTCCGGGCAGGTGGTGCAGTTCTCTCATCGATCGTCGCGCGCAGAGCCGTACACCGTTCGGACCGTCGAGCCGTGGGGTGTGGTTACCGAGAAGGGCCGCTGGTATCTGGTCGGCCACGACCGCGACCGGGATGCAACCCGCGTCTTCCGGCTGTCCCGGATCGGAGCGCAGGTGACGCCAATCGGGCCGGCCGGCGCAACCACCGTGCCTGCCGGTGTGGACCTACGCAGCATCGTGGCGCAGAAGGTGACGGAGGTGCCGACCGGTGAGCAAGCCACGGTATGGGTAGCCGAGGGTCGGGCCACCGCGTTGCGACGTGCCGGGCGGTCCGCCGGGCCGCGACAACTTGGTGGTCGCGATGGCGAGGTGATCGAGCTTGAGATTCGATCCAGCGACCGGCTGGCGCGTGAGATCACCGGCTATGGGGCCGACGCAATCGTGCTGCAGCCCGGGTCTCTGCGCGACGATGTGCTGGCCCGACTACGCGCGCAAGCCGGAGCACTGGCATG
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Part of the pafABC operon, however PafB does not seem to be involved in pupylation or substrate degradation. Appears to play at least a small role in resistance to reactive nitrogen intermediates (RNI) in vitro. {ECO:0000269|PubMed:17277063}.

Family

PafB family

GO

cell wall GO:0005618 cellular_component
plasma membrane GO:0005886 cellular_component

InterPro

IPR026881

UniProt: P9WIM1
GenBank: Rv2096c
EnsemblBacteria: Rv2096c
Mycobrowser: Rv2096c

Summary

Name: Protein PafB (Proteasome accessory factor B)
Family: PafB family
Protein Sequence: MATSKVERLVNLVIALLSTRGYITAEKIRSSVAGYSDSPSVEAFSRMFERDKNELRDLGIPLEVGRVSALEPTEGYRINRDAYALSPVELTPDEAAAVAVATQLWESPELITATQGALLKLRAAGVDVDPLDTGAPVAIASAAAVSGLRGSEDVLGILLSAIDSGQVVQFSHRSSRAEPYTVRTVEPWGVVTEKGRWYLVGHDRDRDATRVFRLSRIGAQVTPIGPAGATTVPAGVDLRSIVAQKVTEVPTGEQATVWVAEGRATALRRAGRSAGPRQLGGRDGEVIELEIRSSDRLAREITGYGADAIVLQPGSLRDDVLARLRAQAGALA
Mass: 35,300 Da
Length: 332 Aa

Rv2096c doesn't seem to be a targeted by any drug.

Rv2096c doesn't seem to be involved in any pathway.

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.
Characterization of the proteasome accessory factor (paf) operon in Mycobacterium tuberculosis.: J Bacteriol. 2007 Apr;189(8):3044-50. doi: 10.1128/JB.01597-06. Epub 2007 Feb 2.