Gene - combatTB X

Type: protein_coding
Name: PPE36
Locus Name: Rv2108
Product: PPE family protein PPE36
Functional Category: Pe/ppe
Location: 2367711..2368442 (+ strand)
Gene Length: 731 bp
Nucleotides: TGCCCAATTTCTGGGCGTTGCCGCCCGAGATCAACTCCACCCGGATATATCTCGGCCCGGGTTCTGGCCCGATACTGGCCGCCGCCCAGGGATGGAACGCTCTGGCCAGTGAGCTGGAAAAGACGAAGGTGGGGTTGCAGTCAGCGCTCGACACGTTGCTGGAGTCGTATAGGGGTCAGTCGTCGCAGGCTTTGATACAGCAGACCTTGCCGTATGTGCAGTGGCTGACCACGACCGCCGAGCACGCCCATAAGACCGCGATCCAGCTCACGGCAGCGGCGAACGCCTACGAGCAGGCTAGAGCGGCGATGGTGCCGCCGGCGATGGTGCGCGCGAACCGCGTGCAGACCACAGTGTTGAAGGCAATCAACTGGTTCGGGCAATTCTCCACCAGGATCGCCGACAAGGAGGCCGACTACGAACAGATGTGGTTCCAAGACGCGCTAGTGATGGAGAACTATTGGGAAGCCGTGCAAGAGGCGATACAGTCGACGTCGCATTTTGAGGATCCACCGGAGATGGCCGACGACTACGACGAGGCCTGGATGCTCAACACCGTGTTCGACTATCACAACGAGAACGCAAAAGAGGAGGTCATCCATCTCGTGCCCGACGTGAACAAGGAGAGGGGGCCCATCGAACTCGTAACCAAGGTAGACAAAGAGGGGACCATCAGACTCGTCTACGATGGGGAGCCCACGTTTTCATACAAGGAACATCCTAAGTTTTGA
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Unknown

Family

Mycobacterial PPE family

GO

InterPro

Summary

Name: Uncharacterized PPE family protein PPE36
Family: Mycobacterial PPE family
Protein Sequence: MPNFWALPPEINSTRIYLGPGSGPILAAAQGWNALASELEKTKVGLQSALDTLLESYRGQSSQALIQQTLPYVQWLTTTAEHAHKTAIQLTAAANAYEQARAAMVPPAMVRANRVQTTVLKAINWFGQFSTRIADKEADYEQMWFQDALVMENYWEAVQEAIQSTSHFEDPPEMADDYDEAWMLNTVFDYHNENAKEEVIHLVPDVNKERGPIELVTKVDKEGTIRLVYDGEPTFSYKEHPKF
Mass: 27,480 Da
Length: 243 Aa

Rv2108 doesn't seem to be a targeted by any drug.

Rv2108 doesn't seem to be involved in any pathway.

Flagellin as a good carrier and potent adjuvant for Th1 response: study of mice immune response to the p27 (Rv2108) Mycobacterium tuberculosis antigen.: Mol Immunol. 2008 May;45(9):2499-507. doi: 10.1016/j.molimm.2008.01.005. Epub 2008 Mar 4.
Expression, immunochemical characterization and localization of the Mycobacterium tuberculosis protein p27.: Tuberculosis (Edinb). 2005 Jul;85(4):213-9. doi: 10.1016/j.tube.2005.02.002. Epub 2005 Apr 22.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.
Cloning of a gene from Mycobacterium tuberculosis coding for a hypothetical 27 kDa protein and its use for the specific PCR identification of these mycobacteria.: Mol Cell Probes. 2000 Aug;14(4):241-8. doi: 10.1006/mcpr.2000.0310.