Function

Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. The M.tuberculosis proteasome is able to cleave oligopeptides not only after hydrophobic but also after basic, acidic and small neutral residues (PubMed:16468985). In complex with the ATPase Mpa, degrades protein targets conjugated to a prokaryotic ubiquitin-like protein (Pup). Among the identified substrates of the M.tuberculosis proteasome are the pupylated FabD, PanB and Mpa proteins (PubMed:17082771). One function of the proteasome is to contribute to M.tuberculosis ability to resist killing by host macrophages, since the core proteasome is essential for persistence of the pathogen during the chronic phase of infection in mice (PubMed:18059281). Likely functions to recycle amino acids under nutrient starvation, thereby enabling the cell to maintain basal metabolic activities (PubMed:20711362) (By similarity). The mechanism of protection against bactericidal chemistries of the host's immune response probably involves the degradation of proteins that are irreversibly oxidized, nitrated, or nitrosated. A proteolysis-independent activity of the proteasome core is required for optimal growth of M.tuberculosis in mouse lungs and for RNI resistance; in contrast, long-term survival of M.tuberculosis in stationary phase and during starvation in vitro and in the chronic phase of mouse infection required a proteolytically active proteasome (PubMed:20711362). {ECO:0000250|UniProtKB:A0QZ46, ECO:0000255|HAMAP-Rule:MF_00289, ECO:0000269|PubMed:16468985, ECO:0000269|PubMed:17082771, ECO:0000269|PubMed:18059281, ECO:0000269|PubMed:20711362}.

Family

Peptidase T1A family

GO

• proteolysis involved in cellular protein catabolic process GO:0051603 biological_process
• threonine-type endopeptidase activity GO:0004298 molecular_function
• cytoplasm GO:0005737 cellular_component
• plasma membrane GO:0005886 cellular_component
• proteasome core complex GO:0005839 cellular_component
• cell wall GO:0005618 cellular_component
• proteasome core complex, alpha-subunit complex GO:0019773 cellular_component
• modification-dependent protein catabolic process GO:0019941 biological_process
• pathogenesis GO:0009405 biological_process
• proteasomal protein catabolic process GO:0010498 biological_process

InterPro

• IPR029055
• IPR023332
• IPR022296
• IPR001353

UniProt

P9WHU1

GenBank

Rv2109c

EnsemblBacteria

Rv2109c

Mycobrowser

Rv2109c

Rv2109c doesn't seem to be a targeted by any drug.

Rv2109c doesn't seem to be involved in any pathway.