Gene - combatTB X

PPE37

Type: protein_coding
Name: PPE37
Locus Name: Rv2123
Product: PPE family protein PPE37
Functional Category: Pe/ppe
Location: 2381071..2382492 (+ strand)
Gene Length: 1421 bp
Nucleotides: TGACCTTCCCGATGTGGTTCGCAGTTCCGCCGGAAGTGCCGTCAGCATGGCTGTCCACCGGCATGGGCCCCGGTCCGCTGCTGGCCGCGGCCAGGGCGTGGCACGCGCTGGCCGCGCAATACACCGAAATTGCAACGGAACTCGCAAGCGTGCTCGCTGCGGTGCAGGCAAGCTCGTGGCAGGGGCCCAGCGCCGACCGGTTCGTCGTCGCCCATCAACCGTTCCGGTATTGGCTAACCCACGCTGCCACGGTGGCCACCGCAGCAGCCGCCGCGCACGAAACGGCCGCCGCCGGGTATACGTCCGCATTGGGGGGCATGCCTACGCTAGCCGAGTTGGCGGCCAACCATGCCATGCACGGCGCTCTGGTGACCACCAACTTCTTCGGTGTCAACACCATCCCGATCGCCCTCAACGAGGCCGACTACCTGCGCATGTGGATCCAGGCCGCCACCGTCATGAGCCACTATCAAGCCGTCGCGCACGAAAGCGTGGCGGCGACCCCCAGCACGCCGCCGGCGCCGCAGATAGTGACCAGTGCGGCCAGCTCGGCGGCTAGCAGCAGCTTCCCCGACCCGACCAAATTGATCCTGCAGCTACTCAAGGATTTCCTGGAGCTGCTGCGCTATCTGGCTGTTGAGCTGCTGCCGGGGCCGCTCGGCGACCTCATCGCCCAGGTGTTGGACTGGTTCATCTCGTTCGTGTCCGGTCCAGTCTTCACGTTTCTCGCCTACCTGGTGCTGGACCCACTGATCTATTTCGGACCGTTCGCCCCGCTGACGAGTCCGGTCCTGTTGCCTGCCGGGCTGACCGGGCTTGCCGGGCTCGGTGCGGTATCGGGGCCGGCCGGACCAATGGTCGAACGTGTGCACTCCGATGGTCCCAGCCGGCAAAGCTGGCCTGCGGCCACCGGAGTCACCCTGGTGGGTACCAACCCGGCTGCCCTGGTTACCACGCCCGCACCCGCTCCGACCACGTCCGCGGCACCGACGGCACCGTCGACTCCCGGATCCAGTGCCGCCCAAGGCCTTTACGCGGTCGGTGGTCCCGACGGGGAAGGGTTCAACCCGATCGCCAAGACGACAGCACTCGCCGGTGTTACCACCGATGCCGCCGCACCTGCCGCCAAACTGCCCGGCGACCAAGCTCAGAGCAGCGCCAGCAAAGCAACAAGACTGCGGCGACGTCTCCGGCAACACCGCTTCGAGTTTCTGGCCGACGACGGCCGCCTGACCATGCCAAACACACCGGAGATGGCAGACGTCGCCGCCGGCAACCGTGGATTGGATGCGCTGGGGTTCGCCGGCACGATCCCAAAATCGGCGCCCGGATCAGCGACCGGGCTTACTCACCTAGGCGGCGGATTCGCCGACGTCCTGTCGCAGCCGATGCTTCCGCACACGTGGGACGGGTCAGATTAA
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Unknown

Family

Mycobacterial PPE family

GO

response to host immune response GO:0052572 biological_process
response to host iron concentration GO:0075139 biological_process

InterPro

UniProt: Q79FH3
GenBank: Rv2123
EnsemblBacteria: Rv2123
Mycobrowser: Rv2123

Summary

Name: Uncharacterized PPE family protein PPE37
Family: Mycobacterial PPE family
Protein Sequence: MTFPMWFAVPPEVPSAWLSTGMGPGPLLAAARAWHALAAQYTEIATELASVLAAVQASSWQGPSADRFVVAHQPFRYWLTHAATVATAAAAAHETAAAGYTSALGGMPTLAELAANHAMHGALVTTNFFGVNTIPIALNEADYLRMWIQAATVMSHYQAVAHESVAATPSTPPAPQIVTSAASSAASSSFPDPTKLILQLLKDFLELLRYLAVELLPGPLGDLIAQVLDWFISFVSGPVFTFLAYLVLDPLIYFGPFAPLTSPVLLPAGLTGLAGLGAVSGPAGPMVERVHSDGPSRQSWPAATGVTLVGTNPAALVTTPAPAPTTSAAPTAPSTPGSSAAQGLYAVGGPDGEGFNPIAKTTALAGVTTDAAAPAAKLPGDQAQSSASKATRLRRRLRQHRFEFLADDGRLTMPNTPEMADVAAGNRGLDALGFAGTIPKSAPGSATGLTHLGGGFADVLSQPMLPHTWDGSD
Mass: 48,563 Da
Length: 473 Aa

Rv2123 doesn't seem to be a targeted by any drug.

Rv2123 doesn't seem to be involved in any pathway.

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Both Corynebacterium diphtheriae DtxR(E175K) and Mycobacterium tuberculosis IdeR(D177K) are dominant positive repressors of IdeR-regulated genes in M. tuberculosis.: Infect Immun. 2005 Sep;73(9):5988-94. doi: 10.1128/IAI.73.9.5988-5994.2005.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.