Function

Phosphatase with a broad specificity. Its primary physiological function is to dephosphorylate 3'-phosphoadenosine 5'-phosphate (PAP) and 3'-phosphoadenosine 5'-phosphosulfate (PAPS). Thus, plays a role in mycobacterial sulfur metabolism, since it can serve as a key regulator of the sulfate assimilation pathway by controlling the pools of PAP and PAPS in the cell. To a lesser extent, is also able to hydrolyze inositol 1-phosphate (I-1-P), fructose 1,6-bisphosphate (FBP) (to fructose 6-phosphate (F-6-P)) and AMP in vitro, but this might has no significance in vivo. Glucose-1-phosphate (G-1-P), p-nitrophenyl phosphate (pNPP), and beta-glycerol phosphate (beta-GP) are also good substrates, compared to I-1-P. With much lower efficiency, can also hydrolyze inositol 2-phosphate (I-2-P) and glucose-6-phosphate (G-6-P) in vitro, but not fructose-6-phosphate (F-6-P) and trehalose-6-phosphate (T-6-P). {ECO:0000269|PubMed:16325768, ECO:0000269|PubMed:18454554}.

Family

Inositol monophosphatase superfamily

GO

• phosphatidylinositol phosphorylation GO:0046854 biological_process
• magnesium ion binding GO:0000287 molecular_function
• inositol monophosphate 4-phosphatase activity GO:0052833 molecular_function
• inositol monophosphate 3-phosphatase activity GO:0052832 molecular_function
• 3'-phosphoadenosine 5'-phosphosulfate metabolic process GO:0050427 biological_process
• manganese ion binding GO:0030145 molecular_function
• fructose 1,6-bisphosphate 1-phosphatase activity GO:0042132 molecular_function
• inositol monophosphate 1-phosphatase activity GO:0008934 molecular_function
• plasma membrane GO:0005886 cellular_component
• cobalt ion binding GO:0050897 molecular_function
• 3'(2'),5'-bisphosphate nucleotidase activity GO:0008441 molecular_function
• sulfate assimilation GO:0000103 biological_process

InterPro

• IPR000760
• IPR020583

UniProt

P9WKJ1

GenBank

Rv2131c

EnsemblBacteria

Rv2131c

Mycobrowser

Rv2131c

Rv2131c doesn't seem to be a targeted by any drug.

• 

  Sulfate assimilation R-MTU-936635

  Mycobacterium tuberculosis

  R-MTU-936635

• 

  Sulfur metabolism mtu00920

  mtu00920

  Metabolism; Energy metabolism