Rv2136c
- Type
- protein_coding
- Name
- Rv2136c
- Locus Name
-
Rv2136c
- Product
-
Possible conserved transmembrane protein
- Functional Category
-
Cell wall and cell processes
- Location
- 2396008..2396838 (- strand)
- Gene Length
- 830 bp
- Nucleotides
-
ATGTCTTGGTGGCAAGTCATCGTGTTGGCCGCGGCCCAGGGTTTGACCGAGTTCCTGCCGGTGTCGTCCTCGGGACATCTGGCGATCGTGTCGCGGATCTTCTTCAGCGGCGACGCCGGTGCCTCGTTCACCGCCGTGAGCCAGTTGGGCACCGAGGCCGCCGTAGTGATCTACTTTGCGCGCGATATTGTGCGCATCCTGAGCGCTTGGTTGCACGGCCTGGTCGTGAAGGCACATCGAAACACCGATTATCGGCTGGGCTGGTATGTCATCATCGGCACAATCCCGATCTGCATTCTGGGCCTGTTCTTCAAAGACGACATCCGGTCGGGCGTCCGCAACCTGTGGGTCGTGGTGACCGCGCTGGTGGTGTTTTCCGGGGTGATCGCACTCGCCGAATACGTGGGGCGCCAGAGTCGTCACATTGAGCGGTTGACCTGGCGGGATGCCGTGGTGGTTGGTATTGCCCAAACCCTGGCGCTGGTCCCCGGGGTATCCAGGTCCGGGTCGACCATCAGCGCTGGACTGTTTCTCGGACTCGACCGTGAACTGGCCGCCCGATTCGGATTCCTGCTGGCCATTCCAGCGGTGTTCGCCTCCGGGTTGTTCTCGTTGCCCGACGCATTCCACCCGGTAACCGAGGGCATGAGCGCTACTGGCCCGCAGTTGCTGGTGGCCACCCTGATCGCGTTCGTCCTCGGTCTGACCGCGGTGGCCTGGCTGCTGCGGTTTCTGGTGCGACACAACATGTACTGGTTCGTCGGCTACCGGGTGCTCGTCGGGACGGGCATGCTCGTGCTGCTGGCTACCGGGACGGTAGCCGCGACATG
- Drug Resistance
- Mutations
- Function
- Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin. {ECO:0000255|HAMAP-Rule:MF_01006}.
- Family
-
UppP family
- GO
-
- cell wall organization GO:0071555 biological_process
- response to antibiotic GO:0046677 biological_process
- peptidoglycan biosynthetic process GO:0009252 biological_process
- undecaprenyl-diphosphatase activity GO:0050380 molecular_function
- regulation of cell shape GO:0008360 biological_process
- plasma membrane GO:0005886 cellular_component
- response to nitrosative stress GO:0051409 biological_process
- dephosphorylation GO:0016311 biological_process
- integral component of membrane GO:0016021 cellular_component
- InterPro
Summary
- Name
- Undecaprenyl-diphosphatase (EC 3.6.1.27) (Bacitracin resistance protein) (Undecaprenyl pyrophosphate phosphatase)
- Family
- UppP family
- Protein Sequence
-
MTAAPAMSWWQVIVLAAAQGLTEFLPVSSSGHLAIVSRIFFSGDAGASFTAVSQLGTEAAVVIYFARDIVRILSAWLHGLVVKAHRNTDYRLGWYVIIGTIPICILGLFFKDDIRSGVRNLWVVVTALVVFSGVIALAEYVGRQSRHIERLTWRDAVVVGIAQTLALVPGVSRSGSTISAGLFLGLDRELAARFGFLLAIPAVFASGLFSLPDAFHPVTEGMSATGPQLLVATLIAFVLGLTAVAWLLRFLVRHNMYWFVGYRVLVGTGMLVLLATGTVAAT
- Mass
- 30,276 Da
- Length
- 282 Aa
Rv2136c doesn't seem to be a targeted by any drug.
-
-
Peptidoglycan biosynthesis mtu00550
mtu00550Metabolism; Glycan biosynthesis and metabolism
-
- Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
- Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
- targetTB: a target identification pipeline for Mycobacterium tuberculosis through an interactome, reactome and genome-scale structural analysis.
- BMC Syst Biol. 2008 Dec 19;2:109. doi: 10.1186/1752-0509-2-109.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.