Gene - combatTB X

murC

Type: protein_coding
Name: murC
Locus Name: Rv2152c
Product: Probable UDP-N-acetylmuramate-alanine ligase MurC
Functional Category: Cell wall and cell processes
Location: 2410638..2412122 (- strand)
Gene Length: 1484 bp
Nucleotides: GTGAGCACCGAGCAGTTGCCGCCCGATCTGCGGCGGGTGCACATGGTCGGCATCGGCGGAGCTGGCATGTCGGGCATCGCCCGAATCCTGCTGGACCGCGGCGGGCTGGTCTCCGGGTCAGACGCCAAGGAGTCGCGCGGTGTGCATGCGCTGCGGGCGCGGGGCGCGTTGATCCGGATCGGACACGACGCGTCGTCGCTGGACCTGTTGCCCGGTGGCGCCACGGCGGTCGTCACTACCCATGCCGCCATCCCCAAAACCAACCCCGAGCTCGTCGAAGCGAGGCGCCGCGGCATTCCCGTGGTGCTGCGGCCGGCCGTGCTGGCCAAGTTGATGGCCGGGCGCACCACATTGATGGTCACCGGCACGCACGGCAAGACAACGACGACGTCCATGCTGATCGTCGCCCTGCAGCACTGCGGGCTTGACCCGTCCTTTGCGGTCGGCGGTGAGCTGGGGGAGGCCGGTACCAACGCCCATCACGGCAGTGGCGACTGTTTCGTCGCCGAAGCCGACGAAAGCGATGGCTCGCTGTTGCAGTACACACCCCACGTCGCGGTGATCACCAACATCGAGTCCGATCACCTGGACTTCTACGGCAGCGTCGAGGCGTATGTTGCGGTGTTCGACTCCTTCGTGGAGCGCATTGTCCCCGGGGGTGCGCTGGTGGTGTGCACTGACGACCCCGGAGGGGCCGCGCTGGCTCAGCGCGCGACTGAGCTGGGAATTCGAGTGCTGCGATACGGGTCGGTGCCGGGTGAGACCATGGCAGCCACGTTGGTCTCGTGGCAGCAACAGGGGGTCGGCGCGGTCGCACATATCCGGTTGGCCTCAGAACTAGCCACAGCACAGGGTCCCCGCGTGATGCGGCTGTCGGTGCCCGGGCGACACATGGCGCTCAACGCGCTGGGAGCGCTGCTGGCCGCGGTGCAGATCGGCGCCCCGGCCGACGAGGTGCTCGACGGGCTGGCCGGCTTCGAAGGAGTGCGGCGACGATTCGAACTGGTTGGGACCTGCGGCGTCGGAAAGGCGTCGGTGCGCGTGTTCGATGACTACGCCCACCACCCGACGGAGATCAGCGCGACACTGGCGGCGGCGCGCATGGTGCTCGAACAGGGCGACGGTGGCCGCTGCATGGTTGTGTTTCAACCCCATTTGTATTCGCGGACAAAGGCATTCGCTGCTGAGTTTGGGCGTGCGCTGAATGCCGCTGACGAGGTGTTCGTACTCGACGTCTACGGAGCTCGTGAACAACCGCTGGCCGGTGTCAGCGGAGCCAGCGTCGCTGAGCACGTCACTGTGCCGATGCGCTACGTCCCGGATTTTTCGGCGGTCGCACAGCAAGTGGCCGCCGCCGCTAGTCCGGGCGACGTCATCGTCACGATGGGTGCCGGAGACGTGACCTTGCTGGGCCCGGAAATCCTGACCGCCCTTCGGGTCCGGGCCAACCGAAGCGCCCCCGGCCGTCCGGGGGTGCTGGGATG
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Cell wall formation. {ECO:0000255|HAMAP-Rule:MF_00046}.

Family

MurCDEF family

GO

cell wall organization GO:0071555 biological_process
cell cycle GO:0007049 biological_process
peptidoglycan biosynthetic process GO:0009252 biological_process
UDP-N-acetylmuramate-L-alanine ligase activity GO:0008763 molecular_function
ATP binding GO:0005524 molecular_function
regulation of cell shape GO:0008360 biological_process
cytoplasm GO:0005737 cellular_component
cell division GO:0051301 biological_process

InterPro

UniProt: P9WJL7
GenBank: Rv2152c
EnsemblBacteria: Rv2152c
Mycobrowser: Rv2152c

Summary

Name: UDP-N-acetylmuramate--L-alanine ligase (EC 6.3.2.8) (UDP-N-acetylmuramoyl-L-alanine synthetase)
Family: MurCDEF family
Protein Sequence: MSTEQLPPDLRRVHMVGIGGAGMSGIARILLDRGGLVSGSDAKESRGVHALRARGALIRIGHDASSLDLLPGGATAVVTTHAAIPKTNPELVEARRRGIPVVLRPAVLAKLMAGRTTLMVTGTHGKTTTTSMLIVALQHCGLDPSFAVGGELGEAGTNAHHGSGDCFVAEADESDGSLLQYTPHVAVITNIESDHLDFYGSVEAYVAVFDSFVERIVPGGALVVCTDDPGGAALAQRATELGIRVLRYGSVPGETMAATLVSWQQQGVGAVAHIRLASELATAQGPRVMRLSVPGRHMALNALGALLAAVQIGAPADEVLDGLAGFEGVRRRFELVGTCGVGKASVRVFDDYAHHPTEISATLAAARMVLEQGDGGRCMVVFQPHLYSRTKAFAAEFGRALNAADEVFVLDVYGAREQPLAGVSGASVAEHVTVPMRYVPDFSAVAQQVAAAASPGDVIVTMGAGDVTLLGPEILTALRVRANRSAPGRPGVLG
Mass: 51,177 Da
Length: 494 Aa

Rv2152c doesn't seem to be a targeted by any drug.

Peptidoglycan biosynthesis mtu00550
mtu00550
Metabolism; Glycan biosynthesis and metabolism

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.