ftsW
- Type
- protein_coding
- Name
- ftsW
- Locus Name
-
Rv2154c
- Product
-
FtsW-like protein FtsW
- Functional Category
-
Cell wall and cell processes
- Location
- 2413348..2414922 (- strand)
- Gene Length
- 1574 bp
- Nucleotides
-
GTGCTAACCCGGTTGCTGCGTCGGGGCACCAGCGACACCGACGGCTCCCAGACTCGAGGGGCCGAGCCGGTCGAGGGGCAGCGGACGGGCCCGGAAGAAGCCTCTAACCCGGGTTCGGCGAGGCCCCGCACCCGTTTCGGTGCCTGGCTGGGCCGTCCGATGACCTCGTTTCACCTCATCATCGCCGTTGCCGCATTGCTGACCACCCTTGGACTGATCATGGTGCTGTCGGCATCGGCGGTGCGGTCCTACGACGACGACGGATCGGCTTGGGTGATCTTCGGCAAGCAGGTCTTGTGGACGCTTGTGGGTCTTATCGGCGGCTATGTCTGTCTGCGGATGTCGGTGCGGTTCATGCGGCGCATCGCCTTCTCCGGTTTCGCGATCACCATCGTGATGCTGGTGCTGGTGCTGGTGCCGGGGATCGGCAAGGAGGCCAACGGCTCGCGCGGCTGGTTCGTGGTCGCGGGCTTCTCGATGCAGCCCTCTGAGCTGGCTAAGATGGCGTTCGCCATCTGGGGAGCGCATCTGCTGGCCGCCCGGCGCATGGAACGGGCTTCACTGCGCGAGATGCTGATTCCACTGGTGCCGGCCGCCGTCGTTGCGCTGGCGCTGATCGTGGCCCAGCCCGACCTCGGACAGACCGTGTCGATGGGCATCATCTTGTTGGGCCTGCTGTGGTATGCGGGGCTGCCGCTGCGCGTCTTCCTCAGCTCACTGGCGGCGGTCGTCGTCTCGGCCGCCATCCTGGCGGTGTCCGCGGGCTACCGATCCGACCGGGTGCGGTCGTGGCTCAACCCCGAAAACGATCCGCAAGACTCCGGCTACCAGGCCCGACAGGCAAAGTTCGCGCTGGCTCAAGGTGGCATTTTCGGCGACGGTCTGGGCCAAGGCGTGGCCAAGTGGAACTACTTGCCCAACGCCCACAACGACTTCATTTTCGCCATCATCGGCGAAGAGCTGGGTCTCGTCGGCGCGCTCGGACTGCTGGGGCTATTCGGATTGTTCGCCTACACCGGCATGCGCATCGCTAGCCGGTCCGCCGACCCGTTCCTGCGGCTGCTGACCGCCACCACGACACTGTGGGTGCTGGGACAGGCGTTCATCAACATCGGCTATGTGATCGGGCTGCTGCCCGTCACCGGCCTGCAGCTGCCGCTCATCTCCGCCGGTGGAACCTCCACGGCCGCAACACTTTCGCTGATAGGCATCATCGCCAACGCGGCTCGCCACGAACCGGAGGCGGTGGCCGCGCTGCGGGCTGGGCGCGACGACAAGGTGAACCGGTTGCTGCGGCTGCCGCTGCCCGAGCCGTATCTGCCCCCTCGTCTCGAGGCGTTTCGTGACCGCAAGCGCGCCAACCCGCAACCGGCCCAAACGCAGCCCGCGCGGAAGACCCCCCGCACGGCGCCCGGACAGCCTGCCCGGCAGATGGGCCTGCCCCCGCGACCCGGCTCGCCCCGCACGGCCGATCCGCCGGTTCGTCGATCAGTGCATCATGGAGCTGGCCAGCGGTACGCGGGCCAGCGTCGCACACGGCGCGTTCGGGCATTGGAAGGTCAGCGTTACGGGTG
- Drug Resistance
- Mutations
- Function
- Peptidoglycan polymerase that is essential for cell division. {ECO:0000250|UniProtKB:P39604}.
- Family
-
SEDS family, FtsW subfamily
- GO
-
- cell wall organization GO:0071555 biological_process
- cell division site GO:0032153 cellular_component
- cell cycle GO:0007049 biological_process
- peptidoglycan biosynthetic process GO:0009252 biological_process
- integral component of plasma membrane GO:0005887 cellular_component
- cell division GO:0051301 biological_process
- peptidoglycan glycosyltransferase activity GO:0008955 molecular_function
- lipid-linked peptidoglycan transporter activity GO:0015648 molecular_function
- regulation of cell shape GO:0008360 biological_process
- InterPro
Summary
- Name
- Probable peptidoglycan glycosyltransferase FtsW (PGT) (EC 2.4.1.129) (Cell division protein FtsW) (Cell wall polymerase) (Peptidoglycan polymerase) (PG polymerase)
- Family
- SEDS family, FtsW subfamily
- Protein Sequence
-
MLTRLLRRGTSDTDGSQTRGAEPVEGQRTGPEEASNPGSARPRTRFGAWLGRPMTSFHLIIAVAALLTTLGLIMVLSASAVRSYDDDGSAWVIFGKQVLWTLVGLIGGYVCLRMSVRFMRRIAFSGFAITIVMLVLVLVPGIGKEANGSRGWFVVAGFSMQPSELAKMAFAIWGAHLLAARRMERASLREMLIPLVPAAVVALALIVAQPDLGQTVSMGIILLGLLWYAGLPLRVFLSSLAAVVVSAAILAVSAGYRSDRVRSWLNPENDPQDSGYQARQAKFALAQGGIFGDGLGQGVAKWNYLPNAHNDFIFAIIGEELGLVGALGLLGLFGLFAYTGMRIASRSADPFLRLLTATTTLWVLGQAFINIGYVIGLLPVTGLQLPLISAGGTSTAATLSLIGIIANAARHEPEAVAALRAGRDDKVNRLLRLPLPEPYLPPRLEAFRDRKRANPQPAQTQPARKTPRTAPGQPARQMGLPPRPGSPRTADPPVRRSVHHGAGQRYAGQRRTRRVRALEGQRYG
- Mass
- 56,337 Da
- Length
- 524 Aa
Rv2154c doesn't seem to be a targeted by any drug.
Rv2154c doesn't seem to be involved in any pathway.
- Interaction between FtsW and penicillin-binding protein 3 (PBP3) directs PBP3 to mid-cell, controls cell septation and mediates the formation of a trimeric complex involving FtsZ, FtsW and PBP3 in mycobacteria.
- Mol Microbiol. 2006 Dec;62(6):1655-73.
- Interaction between FtsZ and FtsW of Mycobacterium tuberculosis.
- J Biol Chem. 2002 Jul 12;277(28):24983-7. doi: 10.1074/jbc.M203847200. Epub 2002 May 6.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.