Gene - combatTB X

murD

Type: protein_coding
Name: murD
Locus Name: Rv2155c
Product: Probable UDP-N-acetylmuramoylalanine-D-glutamate ligase MurD
Functional Category: Cell wall and cell processes
Location: 2414934..2416394 (- strand)
Gene Length: 1460 bp
Nucleotides: GTGCTTGACCCTCTGGGGCCGGGTGCGCCCGTGTTGGTAGCCGGTGGCCGGGTGACCGGTCAGGCGGTGGCCGCGGTGCTGACTCGGTTTGGTGCGACGCCGACGGTGTGCGACGACGATCCGGTCATGCTGCGACCGCACGCCGAACGTGGGCTGCCGACCGTTAGTTCCTCGGACGCGGTGCAGCAGATAACCGGGTATGCGCTGGTGGTCGCCAGTCCCGGCTTCTCGCCCGCAACCCCGCTACTGGCCGCGGCCGCGGCGGCGGGGGTGCCGATCTGGGGTGACGTGGAGTTAGCCTGGCGGCTAGACGCAGCGGGCTGCTACGGACCGCCGCGCAGCTGGCTGGTGGTGACCGGCACCAACGGCAAGACCACCACGACGTCGATGCTGCACGCCATGCTGATCGCCGGTGGCCGCCGCGCCGTGCTGTGCGGCAATATCGGCAGTGCGGTGCTGGATGTGCTGGACGAGCCGGCCGAGCTGCTGGCCGTGGAGTTGTCCAGTTTCCAGCTGCACTGGGCGCCGTCGCTGCGGCCCGAGGCCGGCGCGGTGCTCAACATTGCCGAAGACCACCTGGACTGGCATGCCACGATGGCCGAATACACCGCGGCCAAGGCCCGGGTGCTGACCGGCGGGGTAGCGGTGGCCGGGCTGGATGACAGCCGAGCGGCCGCACTGCTGGACGGCTCACCGGCGCAGGTGCGGGTCGGCTTCCGGCTCGGCGAGCCGGCCGCGCGGGAACTGGGCGTGCGCGACGCCCACCTGGTCGATCGCGCCTTCTCCGACGACTTGACGCTGCTGCCGGTCGCGTCGATACCGGTGCCAGGTCCGGTCGGCGTGCTTGACGCCCTGGCCGCGGCGGCGCTGGCCCGCTCGGTCGGGGTGCCCGCCGGTGCGATCGCCGACGCGGTCACGTCGTTTCGAGTGGGCCGACACCGCGCCGAGGTGGTGGCCGTTGCCGACGGCATCACCTACGTGGACGACTCCAAGGCCACCAACCCGCACGCCGCGCGGGCTTCGGTGCTTGCATACCCGAGGGTGGTATGGATCGCCGGTGGCCTGCTCAAGGGCGCGTCGCTTCACGCCGAGGTTGCGGCGATGGCGTCGCGGCTGGTCGGTGCGGTGCTGATCGGCCGGGATCGCGCAGCGGTTGCCGAGGCGTTATCACGACACGCGCCCGATGTCCCAGTCGTTCAGGTTGTGGCAGGCGAGGATACTGGTATGCCTGCGACTGTTGAGGTTCCTGTTGCTTGTGTTCTAGATGTGGCAAAAGATGACAAAGCCGGTGAGACCGTTGGCGCTGCCGTGATGACCGCTGCGGTGGCCGCGGCCCGGCGGATGGCCCAACCCGGTGACACCGTGCTGCTGGCACCGGCCGGCGCCTCATTCGACCAGTTCACCGGTTATGCCGACCGGGGCGAGGCATTCGCGACCGCGGTCCGCGCGGTGATCCGGTA
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). {ECO:0000250}.

Family

MurCDEF family

GO

cell wall organization GO:0071555 biological_process
cell cycle GO:0007049 biological_process
peptidoglycan biosynthetic process GO:0009252 biological_process
UDP-N-acetylmuramoylalanine-D-glutamate ligase activity GO:0008764 molecular_function
ATP binding GO:0005524 molecular_function
cytosol GO:0005829 cellular_component
regulation of cell shape GO:0008360 biological_process
cell division GO:0051301 biological_process

InterPro

UniProt: P9WJL5
GenBank: Rv2155c
EnsemblBacteria: Rv2155c
Mycobrowser: Rv2155c

Summary

Name: UDP-N-acetylmuramoylalanine--D-glutamate ligase (EC 6.3.2.9) (D-glutamic acid-adding enzyme) (UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase)
Family: MurCDEF family
Protein Sequence: MSGLPRSVPDVLDPLGPGAPVLVAGGRVTGQAVAAVLTRFGATPTVCDDDPVMLRPHAERGLPTVSSSDAVQQITGYALVVASPGFSPATPLLAAAAAAGVPIWGDVELAWRLDAAGCYGPPRSWLVVTGTNGKTTTTSMLHAMLIAGGRRAVLCGNIGSAVLDVLDEPAELLAVELSSFQLHWAPSLRPEAGAVLNIAEDHLDWHATMAEYTAAKARVLTGGVAVAGLDDSRAAALLDGSPAQVRVGFRLGEPAARELGVRDAHLVDRAFSDDLTLLPVASIPVPGPVGVLDALAAAALARSVGVPAGAIADAVTSFRVGRHRAEVVAVADGITYVDDSKATNPHAARASVLAYPRVVWIAGGLLKGASLHAEVAAMASRLVGAVLIGRDRAAVAEALSRHAPDVPVVQVVAGEDTGMPATVEVPVACVLDVAKDDKAGETVGAAVMTAAVAAARRMAQPGDTVLLAPAGASFDQFTGYADRGEAFATAVRAVIR
Mass: 50,354 Da
Length: 496 Aa

Rv2155c doesn't seem to be a targeted by any drug.

Peptidoglycan biosynthesis mtu00550
mtu00550
Metabolism; Glycan biosynthesis and metabolism

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.