Gene - combatTB X

Rv2159c

Type: protein_coding
Name: Rv2159c
Locus Name: Rv2159c
Product: Conserved protein
Functional Category: Conserved hypotheticals
Location: 2420631..2421665 (- strand)
Gene Length: 1034 bp
Nucleotides: ATGAAATTTGTCAACCATATTGAGCCCGTCGCGCCCCGCCGAGCCGGCGGCGCGGTCGCCGAGGTCTATGCCGAGGCCCGCCGCGAGTTCGGCCGGCTGCCCGAGCCGCTCGCCATGCTGTCCCCGGACGAGGGACTGCTCACCGCCGGCTGGGCGACGTTGCGCGAGACACTGCTGGTGGGCCAGGTGCCGCGTGGCCGCAAGGAAGCCGTCGCCGCCGCCGTCGCGGCCAGCCTGCGCTGCCCCTGGTGCGTCGACGCACACACCACCATGCTGTACGCGGCAGGCCAAACCGACACCGCCGCGGCGATCTTGGCCGGCACAGCACCTGCCGCCGGTGACCCGAACGCGCCGTATGTGGCGTGGGCGGCAGGAACCGGGACACCGGCGGGACCGCCGGCACCGTTCGGCCCGGATGTCGCCGCCGAATACCTGGGCACCGCGGTGCAATTCCACTTCATCGCACGCCTGGTCCTGGTGCTGCTGGACGAAACCTTCCTGCCGGGGGGCCCGCGCGCCCAACAGCTCATGCGCCGCGCCGGTGGACTGGTGTTCGCCCGCAAGGTGCGCGCGGAGCATCGGCCGGGCCGCTCCACCCGCCGGCTCGAGCCGCGAACGCTGCCCGACGATCTGGCATGGGCAACACCGTCCGAGCCCATAGCAACCGCGTTCGCCGCGCTCAGCCACCACCTGGACACCGCGCCGCACCTGCCGCCACCGACTCGTCAGGTGGTCAGGCGGGTCGTGGGGTCGTGGCACGGCGAGCCAATGCCGATGAGCAGTCGCTGGACGAACGAGCACACCGCCGAGCTGCCCGCCGACCTGCACGCGCCCACCCGTCTTGCCCTGCTGACCGGCCTGGCCCCGCATCAGGTGACCGACGACGACGTCGCCGCGGCCCGATCCCTGCTCGACACCGATGCGGCGCTGGTTGGCGCCCTGGCCTGGGCCGCCTTCACCGCCGCGCGGCGCATCGGCACCTGGATCGGCGCCGCCGCCGAGGGCCAGGTGTCGCGGCAAAACCCGACTGGGTG
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity. {ECO:0000256|SAAS:SAAS00088543}.

Family

AhpD family

GO

peroxiredoxin activity GO:0051920 molecular_function
cell wall GO:0005618 cellular_component
plasma membrane GO:0005886 cellular_component
peroxidase activity GO:0004601 molecular_function

InterPro

UniProt: O06218
GenBank: Rv2159c
EnsemblBacteria: Rv2159c
Mycobrowser: Rv2159c

Summary

Name: Alkyl hydroperoxide reductase AhpD (EC 1.11.1.15)
Family: AhpD family
Protein Sequence: MKFVNHIEPVAPRRAGGAVAEVYAEARREFGRLPEPLAMLSPDEGLLTAGWATLRETLLVGQVPRGRKEAVAAAVAASLRCPWCVDAHTTMLYAAGQTDTAAAILAGTAPAAGDPNAPYVAWAAGTGTPAGPPAPFGPDVAAEYLGTAVQFHFIARLVLVLLDETFLPGGPRAQQLMRRAGGLVFARKVRAEHRPGRSTRRLEPRTLPDDLAWATPSEPIATAFAALSHHLDTAPHLPPPTRQVVRRVVGSWHGEPMPMSSRWTNEHTAELPADLHAPTRLALLTGLAPHQVTDDDVAAARSLLDTDAALVGALAWAAFTAARRIGTWIGAAAEGQVSRQNPTG
Mass: 36,376 Da
Length: 344 Aa

Rv2159c doesn't seem to be a targeted by any drug.

Rv2159c doesn't seem to be involved in any pathway.

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.