Gene - combatTB X

pbpB

Type: protein_coding
Name: pbpB
Locus Name: Rv2163c
Product: Probable penicillin-binding membrane protein PbpB
Functional Category: Cell wall and cell processes
Location: 2425048..2427087 (- strand)
Gene Length: 2039 bp
Nucleotides: GTGAGCCGCGCCGCCCCCAGGCGGGCCAGTCAGTCGCAGTCGACGCGACCGGCGCGCGGTTTGCGCCGGCCACCGGGAGCCCAGGAGGTTGGGCAACGCAAACGGCCCGGCAAAACGCAGAAAGCCCGGCAAGCCCAGGAAGCCACGAAATCCCGCCCTGCGACACGGTCAGACGTCGCACCCGCGGGTCGCTCGACTCGTGCGAGGCGCACCCGGCAGGTGGTGGACGTCGGGACGCGCGGTGCGTCGTTCGTCTTTCGGCATCGGACCGGAAACGCGGTCATCTTGGTGTTGATGTTGGTCGCGGCAACACAATTGTTCTTTCTGCAGGTATCACATGCCGCGGGCCTGCGTGCGCAGGCGGCCGGCCAACTCAAGGTCACCGACGTCCAGCCAGCGGCTCGCGGCAGCATCGTCGACCGCAACAATGACCGGCTCGCGTTCACCATCGAGGCGCGTGCCCTGACGTTCCAGCCGAAGCGGATTCGGCGGCAATTGGAAGAGGCCAGGAAGAAGACGTCGGCTGCACCCGACCCGCAGCAGCGCCTGCGCGATATCGCCCAGGAGGTCGCCGGCAAGCTGAACAACAAGCCAGATGCCGCGGCCGTGCTGAAGAAGCTGCAAAGCGACGAGACCTTCGTCTACTTGGCGCGTGCGGTCGACCCGGCTGTCGCCAGCGCGATCTGCGCGAAGTATCCCGAGGTCGGTGCGGAAAGACAGGATCTGCGTCAGTACCCGGGTGGGTCGCTGGCGGCAAACGTCGTCGGTGGCATCGACTGGGATGGTCATGGGCTGCTGGGTCTGGAGGACTCCCTGGATGCGGTGCTGGCCGGAACCGACGGATCGGTCACCTACGACCGTGGGTCAGACGGCGTCGTCATCCCCGGCAGCTACCGGAATCGGCACAAGGCGGTCCACGGTTCCACCGTCGTGCTCACCCTCGACAACGACATCCAGTTCTACGTGCAGCAGCAGGTGCAGCAGGCCAAGAACCTATCGGGGGCTCACAACGTCTCGGCCGTCGTCCTGGACGCCAAGACCGGCGAGGTGCTCGCGATGGCCAACGACAACACCTTCGACCCGTCGCAAGACATCGGGCGCCAGGGCGACAAGCAGTTGGGCAACCCGGCGGTGTCGTCGCCCTTCGAGCCGGGCTCGGTGAACAAGATCGTCGCCGCGTCCGCGGTCATCGAGCACGGGTTGAGCAGCCCCGACGAGGTGCTACAGGTGCCTGGCTCGATCCAGATGGGCGGTGTTACCGTGCATGACGCTTGGGAGCACGGCGTGATGCCCTATACCACCACGGGGGTGTTCGGAAAGTCCTCCAACGTCGGCACGCTGATGCTTTCCCAACGTGTCGGACCGGAACGCTATTACGATATGCTCCGCAAGTTCGGGTTGGGACAGCGCACCGGCGTGGGCCTGCCCGGTGAGAGCGCCGGACTGGTGCCGCCAATCGACCAGTGGTCGGGCAGTACGTTCGCTAATCTTCCTATTGGCCAAGGTCTTTCGATGACTTTGCTGCAGATGACCGGCATGTACCAGGCCATCGCCAACGATGGAGTGCGGGTACCCCCACGCATTATCAAGGCCACCGTCGCACCCGACGGCAGCCGAACCGAAGAACCGCGCCCCGACGACATTCGCGTGGTGTCGGCGCAGACCGCCCAGACCGTGCGCCAGATGCTGCGTGCCGTGGTGCAACGCGATCCGATGGGCTACCAGCAGGGTACCGGGCCGACGGCCGGGGTGCCCGGCTATCAGATGGCCGGCAAGACCGGTACCGCGCAGCAGATCAACCCTGGCTGCGGCTGCTACTTCGACGACGTGTATTGGATCACCTTCGCCGGAATCGCCACTGCCGACAATCCCCGCTACGTGATCGGCATCATGTTGGACAACCCGGCGCGCAACTCCGACGGCGCGCCTGGGCACTCGGCCGCCCCGCTGTTCCACAACATCGCGGGCTGGCTGATGCAGCGCGAAAACGTCCCGCTGTCACCCGATCCCGGGCCTCCTTTGGTCTTGCAGGCCACCTA
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Synthesis of cross-linked peptidoglycan from the lipid intermediates. {ECO:0000250, ECO:0000269|PubMed:19496931}.

Family

Transpeptidase family

GO

cell wall organization GO:0071555 biological_process
peptidoglycan biosynthetic process GO:0009252 biological_process
penicillin binding GO:0008658 molecular_function
integral component of plasma membrane GO:0005887 cellular_component
regulation of cell shape GO:0008360 biological_process

InterPro

UniProt: L0T911
GenBank: Rv2163c
EnsemblBacteria: Rv2163c
Mycobrowser: Rv2163c

Summary

Name: Penicillin-binding protein PbpB (Penicillin-binding protein 3) (PBP3)
Family: Transpeptidase family
Protein Sequence: MSRAAPRRASQSQSTRPARGLRRPPGAQEVGQRKRPGKTQKARQAQEATKSRPATRSDVAPAGRSTRARRTRQVVDVGTRGASFVFRHRTGNAVILVLMLVAATQLFFLQVSHAAGLRAQAAGQLKVTDVQPAARGSIVDRNNDRLAFTIEARALTFQPKRIRRQLEEARKKTSAAPDPQQRLRDIAQEVAGKLNNKPDAAAVLKKLQSDETFVYLARAVDPAVASAICAKYPEVGAERQDLRQYPGGSLAANVVGGIDWDGHGLLGLEDSLDAVLAGTDGSVTYDRGSDGVVIPGSYRNRHKAVHGSTVVLTLDNDIQFYVQQQVQQAKNLSGAHNVSAVVLDAKTGEVLAMANDNTFDPSQDIGRQGDKQLGNPAVSSPFEPGSVNKIVAASAVIEHGLSSPDEVLQVPGSIQMGGVTVHDAWEHGVMPYTTTGVFGKSSNVGTLMLSQRVGPERYYDMLRKFGLGQRTGVGLPGESAGLVPPIDQWSGSTFANLPIGQGLSMTLLQMTGMYQAIANDGVRVPPRIIKATVAPDGSRTEEPRPDDIRVVSAQTAQTVRQMLRAVVQRDPMGYQQGTGPTAGVPGYQMAGKTGTAQQINPGCGCYFDDVYWITFAGIATADNPRYVIGIMLDNPARNSDGAPGHSAAPLFHNIAGWLMQRENVPLSPDPGPPLVLQAT
Mass: 72,537 Da
Length: 679 Aa

Rv2163c doesn't seem to be a targeted by any drug.

Peptidoglycan biosynthesis mtu00550
mtu00550
Metabolism; Glycan biosynthesis and metabolism

Novel role of Wag31 in protection of mycobacteria under oxidative stress.: Mol Microbiol. 2009 Jul;73(1):103-19. doi: 10.1111/j.1365-2958.2009.06750.x. Epub 2009 Jun 1.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.