Gene - combatTB X

idsA2

Type: protein_coding
Name: idsA2
Locus Name: Rv2173
Product: Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase)
Functional Category: Lipid metabolism
Location: 2434847..2435905 (+ strand)
Gene Length: 1058 bp
Nucleotides: TGGCCGGCGCCATCACCGACCAGCTGCGGAGGTATTTGCACGGCCGCCGCCGTGCGGCCGCCCACATGGGCAGTGACTACGACGGCCTGATCGCCGACCTGGAGGATTTCGTTCTCGGCGGGGGCAAGCGCCTACGACCGCTCTTCGCCTATTGGGGCTGGCACGCCGTTGCCAGTCGGGAACCCGATCCTGATGTGCTGCTGCTGTTTTCCGCGCTGGAACTGCTGCACGCCTGGGCGCTGGTCCACGACGACCTGATCGACCGTTCCGCCACCCGCCGGGGCCGCCCGACCGCCCAGCTGCGCTACGCGGCGCTGCACCGCGATCGGGACTGGCGGGGGTCACCGGACCAGTTCGGCATGTCGGCGGCCATCCTGCTCGGCGACCTCGCACAGGTCTGGGCTGACGACATCGTCTCGAAGGTCTGCCAGTCCGCCCTGGCACCCGATGCCCAGCGGCGAGTGCATCGGGTGTGGGCCGATATCCGCAACGAGGTGCTGGGCGGGCAATACCTCGACATCGTCGCAGAGGCCAGTGCCGCCGAGTCGATCGAGTCGGCGATGAACGTCGCGACGCTCAAGACCGCCTGCTACACGGTATCGCGACCGCTACAGCTTGGGACGGCCGCCGCGGCCGACAGATCCGACGTAGCGGCCATCTTCGAGCATTTCGGAGCGGACCTCGGCGTAGCGTTTCAGTTGCGCGACGACGTGCTTGGCGTGTTTGGCGACCCAGCCGTGACGGGCAAGCCGTCCGGTGACGACCTAAAGTCGGGCAAGCGTACCGTGCTGGTAGCCGAAGCGGTGGAATTGGCGGACAGGTCAGACCCCTTGGCGGCCAAACTATTACGGACCTCGATTGGCACCCGATTGACTGATGCGCAGGTACGTGAACTGCGCACGGTCATCGAGGCAGTGGGCGCGCGCGCCGCCGCGGAGAGCCGCATCGCCGCGCTCACCCAGCGAGCACTGGCCACCCTGGCGTCCGCACCCATCAACGCAACAGCCAAGGCCGGGCTGTCCGAACTGGCCATGATGGCTGCGAACCGGTCCGCCTAA
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Unknown

Family

FPP/GGPP synthase family

GO

isoprenoid biosynthetic process GO:0008299 biological_process
transferase activity GO:0016740 molecular_function

InterPro

UniProt: O53507
GenBank: Rv2173
EnsemblBacteria: Rv2173
Mycobrowser: Rv2173

Summary

Name: Probable geranylgeranyl pyrophosphate synthetase IdsA2 (Ggppsase) (GGPP synthetase) (Geranylgeranyl diphosphate synthase)
Family: FPP/GGPP synthase family
Protein Sequence: MAGAITDQLRRYLHGRRRAAAHMGSDYDGLIADLEDFVLGGGKRLRPLFAYWGWHAVASREPDPDVLLLFSALELLHAWALVHDDLIDRSATRRGRPTAQLRYAALHRDRDWRGSPDQFGMSAAILLGDLAQVWADDIVSKVCQSALAPDAQRRVHRVWADIRNEVLGGQYLDIVAEASAAESIESAMNVATLKTACYTVSRPLQLGTAAAADRSDVAAIFEHFGADLGVAFQLRDDVLGVFGDPAVTGKPSGDDLKSGKRTVLVAEAVELADRSDPLAAKLLRTSIGTRLTDAQVRELRTVIEAVGARAAAESRIAALTQRALATLASAPINATAKAGLSELAMMAANRSA
Mass: 37,781 Da
Length: 352 Aa

Rv2173 doesn't seem to be a targeted by any drug.

Terpenoid backbone biosynthesis mtu00900
mtu00900
Metabolism; Metabolism of terpenoids and polyketides

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.