Gene - combatTB X

mptA

Type: protein_coding
Name: mptA
Locus Name: Rv2174
Product: Alpha(1->6)mannosyltransferase. Possible conserved integral membrane protein.
Functional Category: Cell wall and cell processes
Location: 2435909..2437459 (+ strand)
Gene Length: 1550 bp
Nucleotides: TGACTACTCCGAGCCATGCTCCAGCGGTTGATTTGGCTACAGCGAAAGATGCTGTTGTCCAACACCTTTCGCGACTTTTCGAGTTCACTACCGGTCCGCAGGGCGGACCGGCGCGGCTGGGCTTCGCCGGCGCGGTGCTGATCACCGCAGGCGGGCTGGGAGCCGGCAGCGTCCGCCAACATGACCCGCTGCTGGAGTCGATTCACATGTCCTGGCTGCGCTTCGGCCACGGACTCGTGCTGTCGTCGATTCTGTTGTGGACAGGTGTGGGTGTGATGCTGCTTGCGTGGCTGGGTCTAGGCCGACGGGTCCTCGCCGGCGAAGCCACCGAGTTCACCATGCGGGCAACCACCGTTATCTGGCTGGCGCCGCTACTGCTGTCGGTGCCCGTCTTCAGCCGGGACACTTACTCGTATCTGGCCCAAGGGGCGCTTCTGCGCGACGGTCTGGATCCTTACGCTGTTGGCCCGGTCGGTAATCCCAATGCGCTGCTGGACGACGTAAGCCCGATCTGGACGATCACCACCGCGCCCTACGGTCCTGCGTTCATTCTGGTTGCGAAGTTCGTCACGGTAATCGTCGGCAACAATGTCGTCGCCGGAACCATGCTGTTGCGTTTGTGCATGCTGCCCGGGCTGGCGTTGCTGGTCTGGGCCACTCCACGCTTGGCCAGCCATCTCGGCACCCACGGCCCGACCGCGCTGTGGATCTGCGTGCTGAACCCACTGGTCCTCATCCATCTGATGGGCGGGGTGCACAACGAGATGCTGATGGTGGGTCTGATGACCGCCGGTATCGCGTTGACCGTCCAGGGCCGTAATGTCGCGGGGATCATCCTGATCACCGTTGCGATCGCGGTGAAGGCCACCGCCGGAATCGCGTTGCCCTTCTTGGTCTGGGTTTGGCTGCGTCATCTGCGTGAGCGACGGGGGTACCGGCCGGTCCAGGCGTTCCTGGCAGCCGCCGCGATATCGCTGCTGATCTTCGTCGCGGTGTTCGCGGTGCTGTCTGCGGTAGCCGGCGTTGGCCTAGGGTGGCTGACCGCGCTGGCCGGCTCGGTGAAAATCATCAACTGGCTGACGGTGCCCACCGGGGCGGCCAACGTGATCCACGCGCTGGGCAGAGGGCTCTTCACGGTCGACTTCTACACCTTGCTGCGGATCACCCGGCTGATCGGAATCGTGATCATCGCGGTGTCGCTGCCGCTGTTGTGGTGGCGGTTCCGGCGCGACGACCGGGCCGCGCTGACCGGGGTCGCATGGTCGATGCTGATCGTGGTGCTGTTCGTACCCGCCGCCCTGCCGTGGTACTACTCCTGGCCGCTGGCGGTCGCTGCCCCGTTGGCCCAGGCACGACGGGCGATCGCGGCCATCGCCGGGCTCTCGACTTGGGTGATGGTGATCTTCAAACCCGACGGATCGCACGGGATGTATTCGTGGCTGCACTTCTGGATCGCCACCGCCTGCGCACTGACTGCGTGGTATGTCCTGTATCGGTCACCGGACCGGCGCGGAGTGCAGGCTGCAACCCCGGTGGTCAATACGCCATAG
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Involved in the latter stages of the biosynthesis of the alpha-(1->6) mannan core of lipomannan (LM). Catalyzes the addition of alpha-(1->6)-mannose residue. {ECO:0000269|PubMed:17714444}.

Family

MptA/B family

GO

glycolipid biosynthetic process GO:0009247 biological_process
mannosyltransferase activity GO:0000030 molecular_function
integral component of membrane GO:0016021 cellular_component

InterPro

IPR017822

UniProt: O53508
GenBank: Rv2174
EnsemblBacteria: Rv2174
Mycobrowser: Rv2174

Summary

Name: Alpha-(1->6)-mannopyranosyltransferase A (MptA) (EC 2.4.1.-) (Polyprenyl-1-monophosphorylmannose dependent alpha-(1->6)-mannopyranosyltransferase) (PPM-dependent alpha-(1->6)-mannopyranosyltransferase)
Family: MptA/B family
Protein Sequence: MTTPSHAPAVDLATAKDAVVQHLSRLFEFTTGPQGGPARLGFAGAVLITAGGLGAGSVRQHDPLLESIHMSWLRFGHGLVLSSILLWTGVGVMLLAWLGLGRRVLAGEATEFTMRATTVIWLAPLLLSVPVFSRDTYSYLAQGALLRDGLDPYAVGPVGNPNALLDDVSPIWTITTAPYGPAFILVAKFVTVIVGNNVVAGTMLLRLCMLPGLALLVWATPRLASHLGTHGPTALWICVLNPLVLIHLMGGVHNEMLMVGLMTAGIALTVQGRNVAGIILITVAIAVKATAGIALPFLVWVWLRHLRERRGYRPVQAFLAAAAISLLIFVAVFAVLSAVAGVGLGWLTALAGSVKIINWLTVPTGAANVIHALGRGLFTVDFYTLLRITRLIGIVIIAVSLPLLWWRFRRDDRAALTGVAWSMLIVVLFVPAALPWYYSWPLAVAAPLAQARRAIAAIAGLSTWVMVIFKPDGSHGMYSWLHFWIATACALTAWYVLYRSPDRRGVQAATPVVNTP
Mass: 55,294 Da
Length: 516 Aa

Rv2174 doesn't seem to be a targeted by any drug.

Lipoarabinomannan (LAM) biosynthesis mtu00571
mtu00571
Metabolism; Glycan biosynthesis and metabolism

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Identification of an alpha(1-->6) mannopyranosyltransferase (MptA), involved in Corynebacterium glutamicum lipomanann biosynthesis, and identification of its orthologue in Mycobacterium tuberculosis.: Mol Microbiol. 2007 Sep;65(6):1503-17. doi: 10.1111/j.1365-2958.2007.05884.x. Epub 2007 Aug 21.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.