pknL
- Type
- protein_coding
- Name
- pknL
- Locus Name
-
Rv2176
- Product
-
Probable transmembrane serine/threonine-protein kinase L PknL (protein kinase L) (STPK L)
- Functional Category
-
Regulatory proteins
- Location
- 2437941..2439140 (+ strand)
- Gene Length
- 1199 bp
- Nucleotides
-
TGGTCGAAGCTGGCACGAGGGACCCGTTGGAGAGCGCGCTGCTGGACAGCCGCTATCTGGTCCAGGCCAAGATCGCCAGCGGCGGCACCTCGACGGTCTACCGGGGCCTGGATGTCCGACTCGACCGGCCCGTCGCGCTGAAAGTGATGGATTCTCGCTACGCGGGCGATGAACAGTTTCTGACCCGCTTTCGACTGGAGGCCCGTGCGGTTGCCCGGCTAAATAACCGCGCGCTGGTCGCGGTCTACGACCAGGGCAAAGACGGCAGGCACCCGTTTCTGGTGATGGAGCTCATCGAGGGCGGTACCCTGCGCGAGCTGCTGATAGAACGTGGTCCCATGCCGCCACATGCCGTTGTGGCGGTGCTGCGCCCAGTGCTTGGCGGGCTGGCTGCCGCCCATCGAGCCGGTCTGGTGCATCGCGATGTCAAGCCCGAGAACATCTTGATCTCCGACGACGGCGACGTCAAACTCGCCGATTTCGGGTTGGTCCGCGCGGTCGCCGCCGCTTCAATCACGTCTACCGGCGTCATCCTGGGTACCGCGGCCTACCTGTCCCCTGAGCAGGTCCGTGATGGAAACGCCGATCCTCGAAGCGACGTCTACTCTGTCGGCGTTCTGGTCTACGAGCTGCTAACGGGGCACACACCGTTCACCGGCGACTCGGCCTTGTCGATTGCCTACCAACGGCTTGATGCTGACGTGCCGCGTGCCAGTGCTGTAATCGACGGTGTACCGCCACAATTCGATGAGTTGGTGGCATGTGCAACTGCCCGCAACCCTGCCGACCGATACGCCGATGCGATCGCGATGGGCGCCGATCTGGAGGCGATCGCCGAGGAGCTGGCCCTGCCTGAATTCCGGGTACCGGCGCCGCGCAACTCCGCTCAACACCGGTCGGCCGCGTTGTACCGCAGCCGGATTACCCAGCAAGGGCAGCTGGGTGCCAAACCGGTTCACCACCCTACTCGCCAGCTGACTCGCCAACCCGGCGACTGCTCCGAGCCGGCTTCAGGGTCGGAGCCCGAACACGAGCCGATCACCGGCCAATTCGCCGGCATCGCAATCGAGGAATTCATCTGGGCGCGACAGCACGCCCGTCGAATGGTGCTTGTCTGGGTGTCGGTGGTGCTGGCGATCACCGGGCTAGTGGCGTCCGCGGCATGGACGATCGGGAGCAACCTGAGCGGCCTGCTCTAA
- Drug Resistance
- Mutations
- Function
- Phosphorylates the DNA-binding protein Rv2175c. May be involved in the regulation of cell division and cell envelope biosynthesis. {ECO:0000269|PubMed:18175374, ECO:0000269|PubMed:19457863}.
- Family
-
Protein kinase superfamily, Ser/Thr protein kinase family
- GO
-
- protein autophosphorylation GO:0046777 biological_process
- peptidyl-threonine phosphorylation GO:0018107 biological_process
- negative regulation of fatty acid biosynthetic process GO:0045717 biological_process
- ATP binding GO:0005524 molecular_function
- plasma membrane GO:0005886 cellular_component
- protein serine/threonine kinase activity GO:0004674 molecular_function
- protein kinase activity GO:0004672 molecular_function
- integral component of membrane GO:0016021 cellular_component
- InterPro
Summary
- Name
- Serine/threonine-protein kinase PknL (EC 2.7.11.1)
- Family
- Protein kinase superfamily, Ser/Thr protein kinase family
- Protein Sequence
-
MVEAGTRDPLESALLDSRYLVQAKIASGGTSTVYRGLDVRLDRPVALKVMDSRYAGDEQFLTRFRLEARAVARLNNRALVAVYDQGKDGRHPFLVMELIEGGTLRELLIERGPMPPHAVVAVLRPVLGGLAAAHRAGLVHRDVKPENILISDDGDVKLADFGLVRAVAAASITSTGVILGTAAYLSPEQVRDGNADPRSDVYSVGVLVYELLTGHTPFTGDSALSIAYQRLDADVPRASAVIDGVPPQFDELVACATARNPADRYADAIAMGADLEAIAEELALPEFRVPAPRNSAQHRSAALYRSRITQQGQLGAKPVHHPTRQLTRQPGDCSEPASGSEPEHEPITGQFAGIAIEEFIWARQHARRMVLVWVSVVLAITGLVASAAWTIGSNLSGLL
- Mass
- 42,834 Da
- Length
- 399 Aa
Rv2176 doesn't seem to be a targeted by any drug.
Rv2176 doesn't seem to be involved in any pathway.
- The Mycobacterium tuberculosis Ser/Thr kinase substrate Rv2175c is a DNA-binding protein regulated by phosphorylation.
- J Biol Chem. 2009 Jul 17;284(29):19290-300. doi: 10.1074/jbc.M109.019653. Epub 2009 May 20.
- The Mycobacterium tuberculosis serine/threonine kinase PknL phosphorylates Rv2175c: mass spectrometric profiling of the activation loop phosphorylation sites and their role in the recruitment of Rv2175c.
- Proteomics. 2008 Feb;8(3):521-33. doi: 10.1002/pmic.200700442.
- Molecular cloning and biochemical characterization of a serine threonine protein kinase, PknL, from Mycobacterium tuberculosis.
- Protein Expr Purif. 2008 Apr;58(2):309-17. doi: 10.1016/j.pep.2007.12.012. Epub 2008 Jan 3.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.