Gene - combatTB X

Rv2191

Type: protein_coding
Name: Rv2191
Locus Name: Rv2191
Product: Conserved hypothetical protein
Functional Category: Information pathways
Location: 2453819..2455756 (+ strand)
Gene Length: 1937 bp
Nucleotides: TGCAGGGGCCTAACGTCGCGGCCATGGGTGCAACCGGTGGGACTCAGCTGAGTTTCGCCGACCTGGCACACGCCCAGGGGGCAGCCTGGACCCCAGCCGACGAGATGTCCCTGCGCGAGACCACCTTCGTCGTGGTCGACCTGGAAACCACAGGTGGGCGCACGACGGGTAACGACGCAACACCGCCGGACGCGATCACCGAAATCGGGGCGGTCAAGGTATGCGGCGGCGCGGTGCTCGGTGAATTCGCCACCCTGGTAAACCCGCAACACAGCATTCCGCCCCAGATCGTGCGGCTCACCGGTATCACTACGGCGATGGTGGGTAATGCCCCGACGATCGACGCCGTCCTGCCGATGTTCTTCGAGTTCGCCGGCGACTCGGTGCTCGTGGCCCACAACGCTGGGTTCGATATCGGATTCCTGCGCGCCGCCGCGAGGCGGTGCGATATCACCTGGCCCCAACCACAGGTGTTGTGCACGATGCGGCTGGCCCGGCGGGTGCTGAGCCGAGACGAAGCCCCTAGCGTGCGTCTGGCCGCGCTAGCGCGGCTGTTCGCCGTCGCCAGCAACCCCACCCACCGCGCCCTCGACGACGCTCGCGCCACCGTCGACGTGCTGCACGCACTCATCGAGCGAGTGGGCAACCAGGGCGTGCACACCTATGCCGAGCTGCGCTCGTATCTGCCCAACGTGACCCAGGCGCAGCGCTGCAAACGGGTACTGGCGGAAACACTGCCGCACCGGCCGGGGGTGTACCTGTTCCGCGGACCGTCGGGCGAGGTGCTCTATGTCGGCACCGCGGCGGACTTGCGCCGCCGGGTAAGCCAGTACTTCAACGGCACCGACCGCCGCAAGCGGATGACGGAGATGGTCATGCTGGCCAGCTCGATCGATCATGTCGAATGCGCGCACCCCCTGGAGGCCGGTGTCCGTGAGCTGCGGATGCTGTCGACGCATGCCCCGCCGTATAACCGCAGGTCGAAGTTCCCATACCGGTGGTGGTGGGTGGCGCTCACCGATGAAGCATTTCCACGCCTGTCGGTCATCCGGGCCCCGCGACACGACCGCGTCGTCGGCCCGTTCCGATCCCGCTCCAAGGCCGCCGAGACGGCAGCGCTGCTGGCACGCTGCACGGGACTGCGAACCTGCACCACTCGGCTGACACGTTCCGCCCGGCACGGACCCGCCTGCCCCGAGCTGGAAGTGTCGGCCTGCCCGGCCGCCCGCGACGTCACGGCCGCGCAATACGCCGAGGCGGTACTGCGCGCGGCGGCCTTGATCGGCGGATTGGACAACGCCGCGCTGGCCGCGGCCGTTCAACAGGTCACTGAGCTCGCCGAGCGCCGTCGCTATGAGAGCGCTGCCCGACTGCGTGACCACCTCGCCACCGCCATCGAGGCGTTGTGGCATGGCCAACGATTGCGAGCACTGGCCGCGCTGCCCGAGTTGATCGCCGCCAAGCCGGACGGCCCCAGGGAGGGCGGCTACCAACTGGCCGTCATTCGCCACGGCCAACTCGCCGCTGCCGGCAGGGCACCGCGCGGGGTTCCTCCGATGCCTGTGGTCGACGCCATCCGCCGCGGCGCTCAGGCGATCCTGCCTACGCCGGCACCGCTCGGCGGGGCACTGGTGGAGGAGATCGCGCTCATCGCCCGCTGGCTGGCCGAGCCGGGAGTGCGCATCGTCGGGGTCTCGAACGACGCCGCAGGGTTGGCCTCCCCAGTGCGCTCGGCCGGCCCGTGGGCAGCGTGGGCGGCAACGGCGCGCTCGGCCCAGTTGGCCGGCGAGCAGCTCAGCAGAGGTTGGCAGTCAGATCTGCCGACCGAACCGCACCCATCGCGCGAGCAACTGTTCGGCCGCACCGGTGTCGATTGCCGCACTGGCCCGCCGCAACCCCTCCTCCCAGGCCGGCAGCCATTCAGCACGGCTGGATAA
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Unknown

Family

Unknown

GO

excinuclease repair complex GO:0009380 cellular_component
DNA-directed DNA polymerase activity GO:0003887 molecular_function
cell wall GO:0005618 cellular_component
cytosol GO:0005829 cellular_component
DNA binding GO:0003677 molecular_function
DNA replication GO:0006260 biological_process
plasma membrane GO:0005886 cellular_component
cellular response to DNA damage stimulus GO:0006974 biological_process
exonuclease activity GO:0004527 molecular_function
endonuclease activity GO:0004519 molecular_function

InterPro

UniProt: P9WLJ1
GenBank: Rv2191
EnsemblBacteria: Rv2191
Mycobrowser: Rv2191

Summary

Name: Putative bifunctional exonuclease/endonuclease protein Rv2191 (EC 3.1.-.-)
Family: Unknown
Protein Sequence: MQGPNVAAMGATGGTQLSFADLAHAQGAAWTPADEMSLRETTFVVVDLETTGGRTTGNDATPPDAITEIGAVKVCGGAVLGEFATLVNPQHSIPPQIVRLTGITTAMVGNAPTIDAVLPMFFEFAGDSVLVAHNAGFDIGFLRAAARRCDITWPQPQVLCTMRLARRVLSRDEAPSVRLAALARLFAVASNPTHRALDDARATVDVLHALIERVGNQGVHTYAELRSYLPNVTQAQRCKRVLAETLPHRPGVYLFRGPSGEVLYVGTAADLRRRVSQYFNGTDRRKRMTEMVMLASSIDHVECAHPLEAGVRELRMLSTHAPPYNRRSKFPYRWWWVALTDEAFPRLSVIRAPRHDRVVGPFRSRSKAAETAALLARCTGLRTCTTRLTRSARHGPACPELEVSACPAARDVTAAQYAEAVLRAAALIGGLDNAALAAAVQQVTELAERRRYESAARLRDHLATAIEALWHGQRLRALAALPELIAAKPDGPREGGYQLAVIRHGQLAAAGRAPRGVPPMPVVDAIRRGAQAILPTPAPLGGALVEEIALIARWLAEPGVRIVGVSNDAAGLASPVRSAGPWAAWAATARSAQLAGEQLSRGWQSDLPTEPHPSREQLFGRTGVDCRTGPPQPLLPGRQPFSTAG
Mass: 69,180 Da
Length: 645 Aa

Rv2191 doesn't seem to be a targeted by any drug.

Homologous recombination mtu03440
mtu03440
Genetic Information Processing; Replication and repair

Mismatch repair mtu03430
mtu03430
The Escherichia coli MMR pathway has been extensively studied and is well characterized. In E. coli, the mismatch-activated MutS-MutL-ATP complex licenses MutH to incise the nearest unmethylated GATC sequence. UvrD and an exonuclease generate a gap. This gap is filled by pol III and DNA ligase. The GATC sites are then methylated by Dam. Several human MMR proteins have been identified based on their homology to E. coli MMR proteins. These include human homologs of MutS and MutL. Although E. coli MutS and MutL proteins are homodimers, human MutS and MutL homologs are heterodimers. The role of hemimethylated dGATC sites as a signal for strand discrimination is not conserved from E. coli to human. Human MMR is presumed to be nick-directed in vivo, and is thought to discriminate daughter and template strands using a strand-specific nick.

DNA replication mtu03030
mtu03030
Genetic Information Processing; Replication and repair

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.