qcrA
- Type
- protein_coding
- Name
- qcrA
- Locus Name
-
Rv2195
- Product
-
Probable rieske iron-sulfur protein QcrA
- Functional Category
-
Intermediary metabolism and respiration
- Location
- 2458392..2459681 (+ strand)
- Gene Length
- 1289 bp
- Nucleotides
-
TGAGCCGCGCCGACGACGATGCAGTGGGGGTACCACCCACTTGCGGGGGACGAAGCGATGAGGAGGAGCGGCGCATAGTGCCCGGACCTAACCCGCAAGACGGGGCCAAAGACGGGGCTAAGGCAACCGCCGTCCCCCGTGAACCGGACGAAGCCGCGCTGGCCGCGATGTCCAACCAGGAGCTGCTCGCATTGGGCGGCAAGCTGGATGGTGTCCGGATCGCCTACAAAGAGCCCCGCTGGCCGGTCGAGGGCACCAAAGCCGAGAAGCGCGCCGAGCGTTCAGTGGCGGTGTGGCTTTTGCTAGGTGGCGTGTTCGGACTGGCGCTGTTGCTGATCTTCCTGTTCTGGCCGTGGGAGTTCAAGGCGGCGGATGGCGAAAGCGACTTCATCTACTCGCTGACTACCCCGCTCTACGGCCTGACTTTCGGATTGTCCATCCTGTCGATCGCCATCGGCGCCGTGTTGTATCAGAAAAGGTTTATTCCCGAAGAGATTTCAATCCAGGAACGTCACGATGGCGCTTCGCGGGAGATCGACCGCAAGACGGTGGTGGCGAACCTGACCGACGCGTTCGAGGGCTCGACGATCCGACGGCGCAAGCTGATCGGGCTGTCCTTCGGCGTGGGCATGGGTGCGTTCGGGCTAGGCACCTTGGTCGCGTTTGCTGGTGGCCTCATCAAGAACCCCTGGAAGCCGGTTGTCCCCACCGCCGAGGGCAAAAAGGCGGTGCTCTGGACGTCGGGTTGGACCCCCCGCTACCAGGGCGAGACGATCTATCTGGCGCGCGCCACCGGCACGGAGGACGGACCACCGTTCATCAAAATGCGCCCGGAGGATATGGACGCCGGTGGAATGGAGACCGTTTTTCCCTGGCGGGAGTCCGACGGCGACGGCACCACCGTCGAATCACACCATAAGCTGCAGGAAATCGCGATGGGTATCCGTAACCCGGTGATGCTCATCCGGATCAAACCCAGTGACCTGGGCCGCGTGGTCAAGCGCAAGGGCCAGGAGAGTTTCAACTTCGGCGAATTCTTCGCGTTCACCAAGGTCTGCTCTCATTTGGGTTGCCCGTCATCGCTGTACGAGCAGCAGAGCTACCGAATCCTGTGCCCTTGTCACCAGTCGCAGTTCGACGCATTGCATTTCGCTAAGCCGATCTTCGGTCCAGCGGCCCGCGCCTTGGCGCAACTGCCGATCACGATCGACACGGACGGGTATCTGGTCGCCAACGGTGACTTTGTCGAGCCCGTCGGACCAGCATTCTGGGAGCGAACAACAACATGA
- Drug Resistance
- Mutations
- Function
- Iron-sulfur subunit of the cytochrome bc1 complex, an essential component of the respiratory electron transport chain required for ATP synthesis. The bc1 complex catalyzes the oxidation of menaquinol and the reduction of cytochrome c in the respiratory chain. The bc1 complex operates through a Q-cycle mechanism that couples electron transfer to generation of the proton gradient that drives ATP synthesis. {ECO:0000305}.
- Family
-
Unknown
- GO
-
- metal ion binding GO:0046872 molecular_function
- electron transport chain GO:0022900 biological_process
- cell wall GO:0005618 cellular_component
- integral component of plasma membrane GO:0005887 cellular_component
- plasma membrane GO:0005886 cellular_component
- 2 iron, 2 sulfur cluster binding GO:0051537 molecular_function
- respirasome GO:0070469 cellular_component
- oxidoreductase activity, acting on diphenols and related substances as donors GO:0016679 molecular_function
- InterPro
Summary
- Name
- Cytochrome bc1 complex Rieske iron-sulfur subunit (Cytochrome bc1 reductase complex subunit QcrA) (Rieske iron-sulfur protein) (Ubiquinol--cytochrome c reductase iron-sulfur subunit)
- Family
- Unknown
- Protein Sequence
-
MSRADDDAVGVPPTCGGRSDEEERRIVPGPNPQDGAKDGAKATAVPREPDEAALAAMSNQELLALGGKLDGVRIAYKEPRWPVEGTKAEKRAERSVAVWLLLGGVFGLALLLIFLFWPWEFKAADGESDFIYSLTTPLYGLTFGLSILSIAIGAVLYQKRFIPEEISIQERHDGASREIDRKTVVANLTDAFEGSTIRRRKLIGLSFGVGMGAFGLGTLVAFAGGLIKNPWKPVVPTAEGKKAVLWTSGWTPRYQGETIYLARATGTEDGPPFIKMRPEDMDAGGMETVFPWRESDGDGTTVESHHKLQEIAMGIRNPVMLIRIKPSDLGRVVKRKGQESFNFGEFFAFTKVCSHLGCPSSLYEQQSYRILCPCHQSQFDALHFAKPIFGPAARALAQLPITIDTDGYLVANGDFVEPVGPAFWERTTT
- Mass
- 46,923 Da
- Length
- 429 Aa
Rv2195 doesn't seem to be a targeted by any drug.
-
-
Oxidative phosphorylation mtu00190
mtu00190PATHWAY_MAP mtu00190 Oxidative phosphorylation
-
- Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
- Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
- targetTB: a target identification pipeline for Mycobacterium tuberculosis through an interactome, reactome and genome-scale structural analysis.
- BMC Syst Biol. 2008 Dec 19;2:109. doi: 10.1186/1752-0509-2-109.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.