gcvT
- Type
- protein_coding
- Name
- gcvT
- Locus Name
-
Rv2211c
- Product
-
Probable aminomethyltransferase GcvT (glycine cleavage system T protein)
- Functional Category
-
Intermediary metabolism and respiration
- Location
- 2476042..2477181 (- strand)
- Gene Length
- 1139 bp
- Nucleotides
-
GTGTGCCAGCAGGGACGCCCATTAGGGTGGGACGCCGTGAGCGATGTGCCAGAGCTGATACACGGACCGCTGGAAGACCGCCATCGCGAGCTGGGTGCGAGTTTCGCCGAGTTCGGCGGCTGGCTGATGCCGGTCTCGTATGCCGGAACCGTCAGCGAGCACAACGCCACCCGCACCGCCGTCGGCCTTTTCGACGTCAGCCACCTGGGCAAGGCACTGGTCCGTGGACCGGGTGCGGCGCAGTTCGTCAACTCCGCGCTCACCAACGACCTGGGTCGTATCGGGCCCGGCAAGGCGCAATACACCTTGTGCTGCACCGAATCCGGCGGTGTGATCGACGACCTGATCGCCTACTACGTCAGCGACGACGAGATCTTTCTGGTGCCCAACGCCGCCAATACCGCCGCGGTGGTCGGCGCGCTACAAGCTGCCGCACCGGGCGGTCTGAGCATCACCAATCTGCATCGGTCCTACGCGGTGCTGGCCGTACAGGGGCCGTGTTCGACCGACGTGCTCACCGCGTTGGGGCTGCCAACCGAGATGGACTACATGGGCTACGCCGACGCTTCGTACTCGGGGGTGCCGGTGCGTGTCTGTCGCACCGGCTACACCGGTGAGCACGGTTACGAACTGCTGCCGCCATGGGAGTCGGCGGGTGTGGTGTTCGACGCACTGTTGGCGGCGGTATCAGCCGCGGGCGGCGAGCCCGCCGGCCTCGGTGCTCGCGACACACTGCGCACTGAAATGGGCTATCCGCTGCACGGGCACGAGCTTTCGCTGGACATCTCGCCGCTGCAGGCCCGATGCGGCTGGGCGGTCGGCTGGCGGAAGGACGCCTTCTTTGGTCGTGCGGCGTTGTTGGCCGAGAAAGCGGCCGGGCCGCGGCGGCTGCTGCGGGGGCTGCGCATGGTCGGTCGCGGTGTGCTGCGCCCCGGGCTGGCTGTGCTTGTCGGGGATGAGACGGTTGGGGTCACCACGTCGGGAACGTTTTCTCCCACGTTGCAGGTCGGCATCGGGCTGGCGCTGATCGACAGTGATGCCGGCATCGAAGACGGCCAGCAAATCAATGTCGACGTCCGCGGCCGTGCTGTCGAATGTCAAGTGGTGTGTCCGCCGTTCGTTGCCGTGAAAACGCGCTG
- Drug Resistance
- Mutations
- Function
- The glycine cleavage system catalyzes the degradation of glycine. {ECO:0000255|HAMAP-Rule:MF_00259}.
- Family
-
GcvT family
- GO
-
- glycine decarboxylation via glycine cleavage system GO:0019464 biological_process
- cell wall GO:0005618 cellular_component
- aminomethyltransferase activity GO:0004047 molecular_function
- transaminase activity GO:0008483 molecular_function
- cytosol GO:0005829 cellular_component
- InterPro
Summary
- Name
- Aminomethyltransferase (EC 2.1.2.10) (Glycine cleavage system T protein)
- Family
- GcvT family
- Protein Sequence
-
MSDVPELIHGPLEDRHRELGASFAEFGGWLMPVSYAGTVSEHNATRTAVGLFDVSHLGKALVRGPGAAQFVNSALTNDLGRIGPGKAQYTLCCTESGGVIDDLIAYYVSDDEIFLVPNAANTAAVVGALQAAAPGGLSITNLHRSYAVLAVQGPCSTDVLTALGLPTEMDYMGYADASYSGVPVRVCRTGYTGEHGYELLPPWESAGVVFDALLAAVSAAGGEPAGLGARDTLRTEMGYPLHGHELSLDISPLQARCGWAVGWRKDAFFGRAALLAEKAAGPRRLLRGLRMVGRGVLRPGLAVLVGDETVGVTTSGTFSPTLQVGIGLALIDSDAGIEDGQQINVDVRGRAVECQVVCPPFVAVKTR
- Mass
- 38,318 Da
- Length
- 367 Aa
Rv2211c doesn't seem to be a targeted by any drug.
-
-
Glyoxylate and dicarboxylate metabolism mtu00630
mtu00630PATHWAY_MAP mtu00630 Glyoxylate and dicarboxylate metabolism
-
-
-
Glycine, serine and threonine metabolism mtu00260
mtu00260Metabolism; Amino acid metabolism
-
- Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
- Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
- targetTB: a target identification pipeline for Mycobacterium tuberculosis through an interactome, reactome and genome-scale structural analysis.
- BMC Syst Biol. 2008 Dec 19;2:109. doi: 10.1186/1752-0509-2-109.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.