Gene - combatTB X

pepB

Type: protein_coding
Name: pepB
Locus Name: Rv2213
Product: Probable aminopeptidase PepB
Functional Category: Intermediary metabolism and respiration
Location: 2478338..2479885 (+ strand)
Gene Length: 1547 bp
Nucleotides: TGACCACCGAACCGGGTTACCTATCCCCCTCCGTCGCCGTCGCGACCTCGATGCCGAAACGTGGTGTCGGCGCTGCGGTGTTGATCGTGCCGGTCGTCTCGACCGGCGAAGAGGATCGGCCCGGCGCGGTCGTTGCCTCGGCCGAGCCCTTCCTGCGCGCCGACACGGTTGCCGAAATCGAGGCGGGCCTGCGAGCGCTGGACGCCACCGGCGCCAGTGACCAGGTGCACCGGCTGGCGGTGCCGTCGTTGCCGGTGGGCAGCGTCCTGACGGTCGGCCTGGGCAAACCGCGGCGCGAATGGCCGGCCGATACCATCCGCTGCGCCGCCGGCGTGGCCGCGCGTGCGCTCAACAGTTCGGAGGCAGTGATCACCACGCTAGCCGAATTACCTGGCGACGGCATCTGCTCGGCCACCGTCGAGGGGCTGATCCTGGGCAGCTACCGATTCAGCGCCTTCCGCAGCGACAAGACCGCGCCCAAAGACGCCGGACTCCGCAAAATCACCGTGCTCTGCTGTGCAAAGGACGCCAAGAAGCGCGCGTTGCACGGTGCGGCCGTCGCGACCGCGGTGGCCACCGCCCGGGACTTGGTCAACACTCCCCCAAGCCACCTGTTTCCCGCCGAGTTCGCTAAGCGCGCAAAGACTTTGAGCGAATCTGTCGGCCTCGACGTGGAAGTTATCGACGAAAAGGCGCTGAAGAAGGCCGGCTATGGCGGGGTGATTGGTGTCGGCCAGGGCTCGTCGCGGCCGCCGCGACTGGTGCGGTTGATTCATCGGGGATCGCGGCTGGCCAAGAACCCCCAAAAGGCCAAGAAGGTGGCCTTGGTTGGCAAGGGGATCACCTTCGATACCGGCGGCATCTCGATCAAGCCGGCAGCGTCGATGCACCACATGACCTCGGACATGGGCGGAGCGGCCGCGGTGATCGCCACTGTCACGCTGGCTGCCCGGCTGCGACTGCCGATTGACGTGATCGCCACGGTGCCGATGGCCGAGAACATGCCGTCGGCGACGGCGCAGCGCCCGGGCGACGTGCTGACCCAATACGGTGGGACCACCGTCGAGGTGCTCAACACCGACGCGGAGGGCCGGTTGATCCTGGCCGACGCCATCGTCCGGGCATGTGAGGACAAGCCGGACTATCTGATCGAGACATCCACGTTGACCGGTGCGCAAACGGTGGCGCTGGGGACGCGCATACCGGGTGTGATGGGCAGCGACGAGTTCCGCGACCGGGTCGCCGCGATCTCGCAGCGGGTGGGCGAGAACGGCTGGCCGATGCCGCTGCCCGATGACCTCAAGGATGACTTGAAATCCACGGTGGCCGACCTGGCCAATGTGAGTGGCCAGCGTTTCGCAGGCATGCTGGTGGCCGGGGTTTTCCTGCGTGAGTTCGTCGCCGAATCGGTGGATTGGGCGCACATCGACGTGGCCGGCCCGGCCTACAACACCGGCAGCGCCTGGGGTTACACGCCCAAGGGCGCCACCGGTGTGCCCACCCGCACCATGTTCGCGGTGCTCGAGGACATCGCGAAGAACGGGTAG
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity). {ECO:0000250}.

Family

Peptidase M17 family

GO

manganese ion binding GO:0030145 molecular_function
cell wall GO:0005618 cellular_component
plasma membrane GO:0005886 cellular_component
cytoplasm GO:0005737 cellular_component
metalloexopeptidase activity GO:0008235 molecular_function
aminopeptidase activity GO:0004177 molecular_function

InterPro

UniProt: P9WHT3
GenBank: Rv2213
EnsemblBacteria: Rv2213
Mycobrowser: Rv2213

Summary

Name: Probable cytosol aminopeptidase (EC 3.4.11.1) (Leucine aminopeptidase) (LAP) (EC 3.4.11.10) (Leucyl aminopeptidase)
Family: Peptidase M17 family
Protein Sequence: MTTEPGYLSPSVAVATSMPKRGVGAAVLIVPVVSTGEEDRPGAVVASAEPFLRADTVAEIEAGLRALDATGASDQVHRLAVPSLPVGSVLTVGLGKPRREWPADTIRCAAGVAARALNSSEAVITTLAELPGDGICSATVEGLILGSYRFSAFRSDKTAPKDAGLRKITVLCCAKDAKKRALHGAAVATAVATARDLVNTPPSHLFPAEFAKRAKTLSESVGLDVEVIDEKALKKAGYGGVIGVGQGSSRPPRLVRLIHRGSRLAKNPQKAKKVALVGKGITFDTGGISIKPAASMHHMTSDMGGAAAVIATVTLAARLRLPIDVIATVPMAENMPSATAQRPGDVLTQYGGTTVEVLNTDAEGRLILADAIVRACEDKPDYLIETSTLTGAQTVALGTRIPGVMGSDEFRDRVAAISQRVGENGWPMPLPDDLKDDLKSTVADLANVSGQRFAGMLVAGVFLREFVAESVDWAHIDVAGPAYNTGSAWGYTPKGATGVPTRTMFAVLEDIAKNG
Mass: 53,481 Da
Length: 515 Aa

Rv2213 doesn't seem to be a targeted by any drug.

Glutathione metabolism mtu00480
mtu00480
PATHWAY_MAP mtu00480 Glutathione metabolism

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.