lipA
- Type
- protein_coding
- Name
- lipA
- Locus Name
-
Rv2218
- Product
-
Probable lipoate biosynthesis protein A LipA
- Functional Category
-
Intermediary metabolism and respiration
- Location
- 2485273..2486208 (+ strand)
- Gene Length
- 935 bp
- Nucleotides
-
TGAGTGTCGCTGCCGAGGGCCGGCGCCTGTTACGCCTGGAGGTGCGCAACGCGCAGACCCCAATCGAGCGCAAACCGCCGTGGATCAAGACACGAGCCCGCATCGGGCCGGAGTACACCGAGCTGAAGAACCTGGTCCGCCGCGAGGGGCTGCACACGGTCTGCGAGGAGGCCGGCTGCCCCAACATCTTCGAATGCTGGGAGGACCGAGAAGCCACCTTCCTGATCGGCGGTGACCAGTGCACCCGCCGATGCGATTTCTGCCAGATCGACACCGGAAAGCCCGCCGAGCTGGACCGCGACGAGCCACGCCGAGTCGCCGACAGCGTGCGCACGATGGGCCTGCGCTATGCCACCGTCACCGGCGTGGCTCGCGACGACCTGCCTGACGGCGGGGCCTGGCTGTACGCCGCGACCGTGCGCGCCATCAAGGAACTCAATCCGTCGACCGGCGTCGAACTGCTGATTCCCGACTTCAACGGCGAACCAACCCGGCTGGCCGAGGTCTTCGAGTCCGGCCCGGAAGTCCTGGCACACAATGTCGAAACCGTGCCCCGTATCTTCAAGCGGATCCGGCCGGCGTTCACGTACCGGCGCAGCCTGGGTGTGCTTACCGCTGCGCGCGACGCCGGCCTGGTCACCAAGAGCAACCTCATCCTCGGCCTGGGCGAAACCTCCGACGAGGTGCGCACCGCCCTGGGCGATCTGCGCGACGCCGGCTGCGACATCGTTACCATCACCCAATACCTGCGGCCGTCGGCGCGCCACCATCCGGTCGAGCGCTGGGTGAAGCCCGAGGAGTTCGTCCAGTTCGCGCGATTCGCCGAAGGGCTGGGCTTCGCCGGGGTATTGGCGGGACCCCTGGTTAGGTCGTCATATCGGGCGGGCCGGCTCTACGAACAGGCACGTAACTCACGGGCCTTGGCATCCCGCTAG
- Drug Resistance
- Mutations
- Function
- Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. {ECO:0000255|HAMAP-Rule:MF_00206}.
- Family
-
Radical SAM superfamily, Lipoyl synthase family
- GO
-
- metal ion binding GO:0046872 molecular_function
- lipoate biosynthetic process GO:0009107 biological_process
- protein lipoylation GO:0009249 biological_process
- cytoplasm GO:0005737 cellular_component
- 4 iron, 4 sulfur cluster binding GO:0051539 molecular_function
- lipoate synthase activity GO:0016992 molecular_function
- InterPro
5EXI
- Name
- Lipoyl synthase (EC 2.8.1.8) (Lip-syn) (LS) (Lipoate synthase) (Lipoic acid synthase) (Sulfur insertion protein LipA)
- Family
- Radical SAM superfamily, Lipoyl synthase family
- Protein Sequence
-
MSVAAEGRRLLRLEVRNAQTPIERKPPWIKTRARIGPEYTELKNLVRREGLHTVCEEAGCPNIFECWEDREATFLIGGDQCTRRCDFCQIDTGKPAELDRDEPRRVADSVRTMGLRYATVTGVARDDLPDGGAWLYAATVRAIKELNPSTGVELLIPDFNGEPTRLAEVFESGPEVLAHNVETVPRIFKRIRPAFTYRRSLGVLTAARDAGLVTKSNLILGLGETSDEVRTALGDLRDAGCDIVTITQYLRPSARHHPVERWVKPEEFVQFARFAEGLGFAGVLAGPLVRSSYRAGRLYEQARNSRALASR
- Mass
- 34,719 Da
- Length
- 311 Aa
Summary
Rv2218 doesn't seem to be a targeted by any drug.
Rv2218 doesn't seem to be involved in any pathway.
- Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
- Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.