ptpA
- Type
- protein_coding
- Name
- ptpA
- Locus Name
-
Rv2234
- Product
-
Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase)
- Functional Category
-
Regulatory proteins
- Location
- 2507146..2507637 (+ strand)
- Gene Length
- 491 bp
- Nucleotides
-
TGTCTGATCCGCTGCACGTCACATTCGTTTGTACGGGCAACATCTGCCGGTCGCCAATGGCCGAGAAGATGTTCGCCCAACAGCTTCGCCACCGTGGCCTGGGTGACGCGGTGCGAGTGACCAGTGCGGGCACCGGGAACTGGCATGTAGGCAGTTGCGCCGACGAGCGGGCGGCCGGGGTGTTGCGAGCCCACGGCTACCCTACCGACCACCGGGCCGCACAAGTCGGCACCGAACACCTGGCGGCAGACCTGTTGGTGGCCTTGGACCGCAACCACGCTCGGCTGTTGCGGCAGCTCGGCGTCGAAGCCGCCCGGGTACGGATGCTGCGGTCATTCGACCCACGCTCGGGAACCCATGCGCTCGATGTCGAGGATCCCTACTATGGCGATCACTCCGACTTCGAGGAGGTCTTCGCCGTCATCGAATCCGCCCTGCCCGGCCTGCACGACTGGGTCGACGAACGTCTCGCGCGGAACGGACCGAGTTGA
- Drug Resistance
- Mutations
- Function
- Mediates host-pathogen interaction and interferes with vesicular trafficking in the infected macrophage. Inhibits host phagolysosomal fusion in M.tuberculosis-infected macrophages to promote bacteria survival. Dephosphorylates host VPS33B protein, which induces a block of the host phagosome maturation within macrophage cells. Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. {ECO:0000269|PubMed:18474358}.
- Family
-
Low molecular weight phosphotyrosine protein phosphatase family
- GO
-
- host cell endosome GO:0044174 cellular_component
- pathogenesis GO:0009405 biological_process
- extracellular region GO:0005576 cellular_component
- plasma membrane GO:0005886 cellular_component
- obsolete modification by symbiont of host morphology or physiology via secreted substance GO:0052046 biological_process
- negative regulation by symbiont of host cell-mediated immune response GO:0052083 biological_process
- protein dephosphorylation GO:0006470 biological_process
- protein tyrosine phosphatase activity GO:0004725 molecular_function
- InterPro
1U2P
- Name
- Probable low molecular weight protein-tyrosine-phosphatase (PTPase) (EC 3.1.3.48)
- Family
- Low molecular weight phosphotyrosine protein phosphatase family
- Protein Sequence
-
MSDPLHVTFVCTGNICRSPMAEKMFAQQLRHRGLGDAVRVTSAGTGNWHVGSCADERAAGVLRAHGYPTDHRAAQVGTEHLAADLLVALDRNHARLLRQLGVEAARVRMLRSFDPRSGTHALDVEDPYYGDHSDFEEVFAVIESALPGLHDWVDERLARNGPS
- Mass
- 17,892 Da
- Length
- 163 Aa
Summary
Rv2234 doesn't seem to be a targeted by any drug.
Rv2234 doesn't seem to be involved in any pathway.
- Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
- Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
- Mycobacterium tuberculosis virulence is mediated by PtpA dephosphorylation of human vacuolar protein sorting 33B.
- Cell Host Microbe. 2008 May 15;3(5):316-22. doi: 10.1016/j.chom.2008.03.008.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.