Gene - combatTB X

Type: protein_coding
Name: fabD
Locus Name: Rv2243
Product: Malonyl CoA-acyl carrier protein transacylase FabD (malonyl CoA:ACPM acyltransferase) (MCT)
Functional Category: Lipid metabolism
Location: 2516787..2517695 (+ strand)
Gene Length: 908 bp
Nucleotides: TGATTGCGTTGCTCGCACCCGGACAGGGTTCGCAAACCGAGGGAATGTTGTCGCCGTGGCTTCAGCTGCCCGGCGCAGCGGACCAGATCGCGGCGTGGTCGAAAGCCGCTGATCTAGATCTTGCCCGGCTGGGCACCACCGCCTCGACCGAGGAGATCACCGACACCGCGGTCGCCCAGCCATTGATCGTCGCCGCGACTCTGCTGGCCCACCAGGAACTGGCGCGCCGATGCGTGCTCGCCGGCAAGGACGTCATCGTGGCCGGCCACTCCGTCGGCGAAATCGCGGCCTACGCAATCGCCGGTGTGATAGCCGCCGACGACGCCGTCGCGCTGGCCGCCACCCGCGGCGCCGAGATGGCCAAGGCCTGCGCCACCGAGCCGACCGGCATGTCTGCGGTGCTCGGCGGCGACGAGACCGAGGTGCTGAGTCGCCTCGAGCAGCTCGACTTGGTCCCGGCAAACCGCAACGCCGCCGGCCAGATCGTCGCTGCCGGCCGGCTGACCGCGTTGGAGAAGCTCGCCGAAGACCCGCCGGCCAAGGCGCGGGTGCGTGCACTGGGTGTCGCCGGAGCGTTCCACACCGAGTTCATGGCGCCCGCACTTGACGGCTTTGCGGCGGCCGCGGCCAACATCGCAACCGCCGACCCCACCGCCACGCTGCTGTCCAACCGCGACGGGAAGCCGGTGACATCCGCGGCCGCGGCGATGGACACCCTGGTCTCCCAGCTCACCCAACCGGTGCGATGGGACCTGTGCACCGCGACGCTGCGCGAACACACAGTCACGGCGATCGTGGAGTTCCCCCCCGCGGGCACGCTTAGCGGTATCGCCAAACGCGAACTTCGGGGGGTTCCGGCACGCGCCGTCAAGTCACCCGCAGACCTGGACGAGCTGGCAAACCTATAA
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Unknown

Family

FabD family

GO

fatty acid synthase complex GO:0005835 cellular_component
cytosol GO:0005829 cellular_component
[acyl-carrier-protein] S-malonyltransferase activity GO:0004314 molecular_function
fatty acid biosynthetic process GO:0006633 biological_process

InterPro

Summary

Name: Malonyl CoA-acyl carrier protein transacylase (MCT) (EC 2.3.1.39)
Family: FabD family
Protein Sequence: MIALLAPGQGSQTEGMLSPWLQLPGAADQIAAWSKAADLDLARLGTTASTEEITDTAVAQPLIVAATLLAHQELARRCVLAGKDVIVAGHSVGEIAAYAIAGVIAADDAVALAATRGAEMAKACATEPTGMSAVLGGDETEVLSRLEQLDLVPANRNAAGQIVAAGRLTALEKLAEDPPAKARVRALGVAGAFHTEFMAPALDGFAAAAANIATADPTATLLSNRDGKPVTSAAAAMDTLVSQLTQPVRWDLCTATLREHTVTAIVEFPPAGTLSGIAKRELRGVPARAVKSPADLDELANL
Mass: 30,788 Da
Length: 302 Aa

Rv2243 doesn't seem to be a targeted by any drug.

Fatty acid biosynthesis mtu00061
mtu00061
PATHWAY_MAP mtu00061 Fatty acid biosynthesis

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Ubiquitin-like protein involved in the proteasome pathway of Mycobacterium tuberculosis.: Science. 2008 Nov 14;322(5904):1104-7. doi: 10.1126/science.1163885. Epub 2008 Oct 2.
Identification of substrates of the Mycobacterium tuberculosis proteasome.: EMBO J. 2006 Nov 15;25(22):5423-32. doi: 10.1038/sj.emboj.7601405. Epub 2006 Nov 2.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.