Function

Primarily hydroxylates the omega-carbon of a number of methyl-branched lipids, including (2E,6E)-farnesol, phytanate, geranylgeraniol, 15-methylpalmitate and (2E,6E)-farnesyl diphosphate (PubMed:19933331). Also catalyzes the sequential oxidation of the terminal methyl of cholest-4-en-3-one into (25R)-26-hydroxycholest-4-en-3-one (alcohol), (25R)-26-oxocholest-4-en-3-one (aldehyde), to finally yield the carboxylic acid (25R)-3-oxocholest-4-en-26-oate (PubMed:20843794). Cyp124 catalyzes preferencially the oxidation of (25R)-26-hydroxycholest-4-en-3-one diastereomer (PubMed:20843794). Also able to sequentially oxidize cholesterol itself, not only cholest-4-en-3-one (PubMed:20843794). {ECO:0000269|PubMed:19933331, ECO:0000269|PubMed:20843794}.

Family

Cytochrome P450 family

GO

• fatty acid omega-oxidation GO:0010430 biological_process
• heme binding GO:0020037 molecular_function
• cholesterol 26-hydroxylase activity GO:0031073 molecular_function
• iron ion binding GO:0005506 molecular_function
• steroid hydroxylase activity GO:0008395 molecular_function
• NADPH binding GO:0070402 molecular_function
• methyl-branched fatty acid metabolic process GO:0097089 biological_process
• cholest-4-en-3-one 26-monooxygenase activity GO:0036199 molecular_function
• cholesterol catabolic process GO:0006707 biological_process

InterPro

• IPR036396
• IPR002397
• IPR001128

UniProt

P9WPP3

GenBank

Rv2266

EnsemblBacteria

Rv2266

Mycobrowser

Rv2266

Rv2266 doesn't seem to be a targeted by any drug.

Rv2266 doesn't seem to be involved in any pathway.