Gene - combatTB X

htpG

Type: protein_coding
Name: htpG
Locus Name: Rv2299c
Product: Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G)
Functional Category: Virulence, detoxification, adaptation
Location: 2570059..2572002 (- strand)
Gene Length: 1943 bp
Nucleotides: ATGAACGCCCATGTCGAGCAGTTGGAGTTTCAGGCGGAGGCCCGGCAACTGCTGGATTTGATGGTCCACTCGGTCTACTCCAATAAGGACGCGTTTCTGCGGGAGTTGATCTCGAATGCCTCCGATGCGCTAGACAAGCTGCGGATTGAGGCGCTGCGGAACAAGGACCTGGAGGTCGACACCTCCGATCTGCACATCGAGATCGACGCAGACAAAGCTGCAAGGACTCTTACCGTTCGTGACAACGGCATCGGGATGGCGCGCGAGGAGGTGGTGGATCTGATTGGCACGCTGGCCAAGTCGGGCACCGCCGAGCTGCGCGCACAGCTGCGTGAGGCCAAGAACGCGGCCGCCTCCGAGGAACTGATCGGTCAGTTCGGCATCGGCTTCTACTCGTCGTTCATGGTGGCCGACAAGGTCCAACTGCTTACCCGCAAGGCTGGCGAGAGCGCGGCCACCAGATGGGAGTCCAGCGGTGAGGGCACCTACACCATCGAGTCCGTCGAGGATGCCCCCCAGGGCACGTCGGTCACCCTGCACCTCAAGCCGGAAGACGCCGAGGACGACCTGCACGACTACACCTCGGAATGGAAGATCCGTAACCTGGTCAAGAAATACTCCGACTTCATCGCCTGGCCCATCCGGATGGACGTCGAGCGCCGCACCCCAGCCTCCCAGGAAGAAGGGGGGGAAGGCGGCGAGGAGACCGTCACCATCGAAACCGAAACCCTCAACTCGATGAAGGCGCTGTGGGCGAGGCCCAAAGAAGAGGTGTCTGAGCAGGAGTACAAGGAGTTCTACAAACACGTCGCGCACGCCTGGGACGACCCGCTCGAGATCATCGCGATGAAGGCCGAGGGCACCTTCGAGTACCAGGCCCTGCTGTTCATCCCGTCTCATGCCCCGTTCGATCTGTTCGACCGGGACGCCCACGTCGGTATCCAGCTCTACGTCAAGCGGGTGTTCATCATGGGCGACTGCGACCAGCTCATGCCCGAGTACTTGCGTTTTGTCAAGGGTGTGGTCGACGCGCAGGACATGTCGCTCAACGTTTCTCGCGAAATCCTGCAGCAGGACCGGCAGATCAAGGCCATCCGCCGGCGGCTGACCAAGAAGGTGCTGTCCACGATCAAGGACGTGCAGTCCAGCCGGCCGGAGGACTACCGCACGTTCTGGACACAGTTCGGCAGGGTCCTCAAAGAGGGACTGCTGTCAGACATCGATAACCGGGAGACCCTGCTCGGTATTTCTTCGTTTGTCTCCACGTACAGCGAGGAGGAACCCACCACGCTGGCCGAATACGTCGAGCGCATGAAGGACGGTCAGCAACAGATCTTCTACGCCACCGGCGAGACGCGCCAACAACTGCTGAAGTCACCGCACCTGGAGGCGTTTAAGGCCAAGGGGTACGAAGTGCTGCTGCTCACCGACCCGGTCGACGAGGTCTGGGTGGGAATGGTGCCGGAGTTCGACGGCAAACCGCTGCAGTCGGTTGCCAAGGGCGAGGTGGACTTGAGTTCCGAAGAGGACACCAGCGAGGCCGAGCGCGAGGAGCGGCAGAAGGAATTTGCCGACCTGCTGACCTGGTTGCAGGAGACGTTGAGCGATCACGTCAAGGAGGTGCGGCTGTCCACCCGCCTGACCGAGTCACCGGCCTGTCTGATCACCGATGCCTTCGGGATGACACCCGCGCTCGCGCGCATCTACCGGGCTTCCGGCCAGGAGGTTCCGGTCGGCAAGCGGATACTTGAGCTCAACCCGAGCCATCCGTTGGTGACCGGCCTGCGCCAAGCCCACCAGGACCGCGCAGACGATGCCGAGAAATCATTGGCCGAAACCGCGGAATTACTTTACGGCACAGCGCTTCTCGCCGAAGGCGGCGCACTCGAGGATCCGGCGAGGTTCGCCGAGCTGCTGGCCGAACGTCTCGCGCGTACCTTGTA
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Molecular chaperone. Has ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00505}.

Family

Heat shock protein 90 family

GO

response to heat GO:0009408 biological_process
cellular response to superoxide GO:0071451 biological_process
cell wall GO:0005618 cellular_component
extracellular region GO:0005576 cellular_component
ATP binding GO:0005524 molecular_function
cytosol GO:0005829 cellular_component
ATPase activity, coupled GO:0042623 molecular_function
plasma membrane GO:0005886 cellular_component
protein folding GO:0006457 biological_process
cellular response to DNA damage stimulus GO:0006974 biological_process
unfolded protein binding GO:0051082 molecular_function

InterPro

UniProt: P9WMJ7
GenBank: Rv2299c
EnsemblBacteria: Rv2299c
Mycobrowser: Rv2299c

Summary

Name: Chaperone protein HtpG (Heat shock protein HtpG) (High temperature protein G)
Family: Heat shock protein 90 family
Protein Sequence: MNAHVEQLEFQAEARQLLDLMVHSVYSNKDAFLRELISNASDALDKLRIEALRNKDLEVDTSDLHIEIDADKAARTLTVRDNGIGMAREEVVDLIGTLAKSGTAELRAQLREAKNAAASEELIGQFGIGFYSSFMVADKVQLLTRKAGESAATRWESSGEGTYTIESVEDAPQGTSVTLHLKPEDAEDDLHDYTSEWKIRNLVKKYSDFIAWPIRMDVERRTPASQEEGGEGGEETVTIETETLNSMKALWARPKEEVSEQEYKEFYKHVAHAWDDPLEIIAMKAEGTFEYQALLFIPSHAPFDLFDRDAHVGIQLYVKRVFIMGDCDQLMPEYLRFVKGVVDAQDMSLNVSREILQQDRQIKAIRRRLTKKVLSTIKDVQSSRPEDYRTFWTQFGRVLKEGLLSDIDNRETLLGISSFVSTYSEEEPTTLAEYVERMKDGQQQIFYATGETRQQLLKSPHLEAFKAKGYEVLLLTDPVDEVWVGMVPEFDGKPLQSVAKGEVDLSSEEDTSEAEREERQKEFADLLTWLQETLSDHVKEVRLSTRLTESPACLITDAFGMTPALARIYRASGQEVPVGKRILELNPSHPLVTGLRQAHQDRADDAEKSLAETAELLYGTALLAEGGALEDPARFAELLAERLARTL
Mass: 72,961 Da
Length: 647 Aa

Rv2299c doesn't seem to be a targeted by any drug.

Rv2299c doesn't seem to be involved in any pathway.

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.