Gene - combatTB X

stp

Type: protein_coding
Name: stp
Locus Name: Rv2333c
Product: Integral membrane drug efflux protein Stp
Functional Category: Cell wall and cell processes
Location: 2606708..2608321 (- strand)
Gene Length: 1613 bp
Nucleotides: ATGAACCGCACGCAGCTCCTCACGCTCATCGCCACTGGCCTGGGCCTGTTCATGATCTTTCTCGACGCACTGATCGTGAACGTGGCGCTGCCCGACATCCAGCGCAGTTTCGCGGTGGGGGAGGACGGCCTGCAGTGGGTGGTGGCGTCCTACAGCCTCGGAATGGCGGTCTTCATCATGTCGGCGGCGACGCTTGCCGACCTCGACGGTCGGCGCCGCTGGTACTTGATAGGTGTTTCGTTGTTCACGCTGGGATCTATCGCCTGCGGGTTGGCGCCCTCAATCGCGGTGCTCACCACCGCGCGGGGCGCGCAGGGCCTAGGTGCGGCGGCCGTCAGCGTAACCTCGCTCGCCCTGGTCAGCGCGGCCTTTCCGGAGGCGAAGGAGAAGGCGCGCGCCATCGGGATCTGGACCGCCATCGCGAGCATCGGTACGACGACGGGCCCGACACTGGGCGGTCTGCTGGTGGACCAGTGGGGGTGGCGCAGCATCTTCTATGTCAACCTGCCCATGGGCGCACTCGTCCTCTTCCTGACTTTGTGCTACGTCGAGGAGTCGTGTAACGAGCGGGCACGCCGCTTCGATCTGTCCGGGCAGCTGCTGTTCATCGTTGCCGTGGGTGCCCTGGTGTATGCGGTCATCGAAGGCCCCCAGATCGGCTGGACGTCTGTCCAGACCATCGTGATGCTCTGGACAGCCGCCGTCGGCTGCGCCCTGTTCGTCTGGCTTGAGCGCAGATCATCGAATCCGATGATGGATCTGACCCTGTTCCGCGACACCTCATACGCCCTGGCCATCGCGACCATCTGCACGGTGTTCTTCGCCGTCTATGGGATGCTGCTGCTCACCACCCAGTTCCTGCAGAACGTGCGCGGCTATACCCCGAGCGTGACCGGCCTGATGATCCTTCCGTTCAGTGCGGCCGTGGCCATCGTGTCGCCACTTGTTGGGCACCTGGTTGGCCGGATCGGAGCACGCGTTCCCATCCTGGCGGGGCTGTGCATGTTGATGCTGGGTCTGCTCATGCTCATCTTCAGCGAGCACCGGAGCTCGGCCCTGGTCCTGGTCGGGCTGGGCTTGTGCGGGAGCGGCGTCGCGTTGTGCCTGACGCCGATCACGACCGTCGCCATGACCGCGGTCCCCGCCGAGCGTGCGGGCATGGCGTCCGGCATCATGAGTGCTCAGCGGGCGATCGGCTCGACGATCGGGTTCGCGGTTTTGGGCTCCGTCCTTGCCGCCTGGCTTTCGGCCACACTCGAGCCCCATCTGGAGCGCGCGGTGCCCGACCCGGTCCAGCGCCACGTCCTTGCCGAGATCATTATCGACAGTGCCAATCCGCGAGCGCATGTGGGCGGAATCGTCCCCCGGCGGCACATTGAGCATCGCGACCCCGTCGCGATTGCGGAGGAGGATTTCATCGAAGGCATTCGGGTGGCGTTGCTCGTCGCCACTGCAACACTGGCTGTCGTGTTTCTCGCCGGCTGGCGATGGTTTCCGCGTGACGTGCACACCGCGGGCAGCGACCTAAGCGAGAGGCTGCCTACAGCGATGACCGTCGAGTGCGCGGTTAGTCATATGCCGGGAGCCACATGGTGTCGACTATGGCCTGCCTG
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Contributes to spectinomycin and tetracycline resistance. {ECO:0000269|PubMed:17242035}.

Family

Major facilitator superfamily, EmrB family

GO

transmembrane transporter activity GO:0022857 molecular_function
response to antibiotic GO:0046677 biological_process
plasma membrane GO:0005886 cellular_component
integral component of membrane GO:0016021 cellular_component

InterPro

UniProt: P9WG91
GenBank: Rv2333c
EnsemblBacteria: Rv2333c
Mycobrowser: Rv2333c

Summary

Name: Multidrug resistance protein Stp (Spectinomycin tetracycline efflux pump)
Family: Major facilitator superfamily, EmrB family
Protein Sequence: MNRTQLLTLIATGLGLFMIFLDALIVNVALPDIQRSFAVGEDGLQWVVASYSLGMAVFIMSAATLADLDGRRRWYLIGVSLFTLGSIACGLAPSIAVLTTARGAQGLGAAAVSVTSLALVSAAFPEAKEKARAIGIWTAIASIGTTTGPTLGGLLVDQWGWRSIFYVNLPMGALVLFLTLCYVEESCNERARRFDLSGQLLFIVAVGALVYAVIEGPQIGWTSVQTIVMLWTAAVGCALFVWLERRSSNPMMDLTLFRDTSYALAIATICTVFFAVYGMLLLTTQFLQNVRGYTPSVTGLMILPFSAAVAIVSPLVGHLVGRIGARVPILAGLCMLMLGLLMLIFSEHRSSALVLVGLGLCGSGVALCLTPITTVAMTAVPAERAGMASGIMSAQRAIGSTIGFAVLGSVLAAWLSATLEPHLERAVPDPVQRHVLAEIIIDSANPRAHVGGIVPRRHIEHRDPVAIAEEDFIEGIRVALLVATATLAVVFLAGWRWFPRDVHTAGSDLSERLPTAMTVECAVSHMPGATWCRLWPA
Mass: 57,115 Da
Length: 537 Aa

Rv2333c doesn't seem to be a targeted by any drug.

Rv2333c doesn't seem to be involved in any pathway.

Contribution of the Rv2333c efflux pump (the Stp protein) from Mycobacterium tuberculosis to intrinsic antibiotic resistance in Mycobacterium bovis BCG.: J Antimicrob Chemother. 2007 Mar;59(3):544-7. doi: 10.1093/jac/dkl510. Epub 2007 Jan 22.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.