Gene - combatTB X

mmpL9

Type: protein_coding
Name: mmpL9
Locus Name: Rv2339
Product: Probable conserved transmembrane transport protein MmpL9
Functional Category: Cell wall and cell processes
Location: 2614693..2617581 (+ strand)
Gene Length: 2888 bp
Nucleotides: TGGTGCCGGGCGAAGTCCACATGAGTGATACGCCGTCAGGCCCGCACCCAATCATCCCGCGGACGATTCGCCTGGCCGCGATTCCCATCTTGCTGTGTTGGCTGGGATTTACCGTTTTCGTCAGCGTCGCCGTTCCTCCGTTGGAGGCGATCGGTGAAACCCGGGCCGTGGCAGTTGCCCCCGACGATGCGCAATCGATGCGTGCGATGCGACGTGCCGGAAAGGTGTTCAACGAATTCGATTCCAATAGCATCGCGATGGTCGTCCTGGAAAGCGATCAACCACTAGGCGAGAAGGCCCATAGGTATTACGACCACCTGGTCGATACGCTCGTACTGGACCAGAGCCATATCCAGCACATTCAAGACTTTTGGCGTGATCCCCTGACGGCGGCGGGTGCGGTCAGCGCAGATGGTAAGGCGGCGTACGTTCAACTTTACCTCGCCGGCAACATGGGTGAAGCACTCGCAAACGAATCCGTTGAAGCCGTCCGGAAAATTGTGGCGAATAGTACACCGCCGGAAGGCATCAGAACCTATGTCACCGGACCGGCGGCCTTGTTTGCCGACCAAATCGCCGCCGGTGACCGAAGCATGAAGCTGATCACCGGATTAACGTTCGCGGTAATCACCGTGTTGCTGCTGCTCGTCTATCGCTCGATCGCCACCACGCTGCTGATTCTTCCCATGGTGTTTATTGGACTCGGCGCGACGCGTGGCACCATTGCCTTTCTTGGATACCACGGAATGGTCGGCCTTTCGACTTTTGTGGTCAATATCCTCACGGCACTTGCCATTGCTGCCGGTACAGACTACGCGATCTTCCTGGTCGGCCGCTATCAAGAAGCCCGCCATATCGGCCAGAATCGCGAAGCCTCTTTCTACACGATGTACAGGGGCACCGCTAACGTCATTCTCGGATCGGGACTGACCATCGCCGGCGCAACATATTGTCTGAGTTTCGCCCGGCTGACGCTGTTTCACACCATGGGGCCTCCGTTGGCAATAGGCATGCTGGTTTCGGTCGCGGCCGCGCTGACCCTGGCGCCCGCCATCATTGCCATCGCCGGCCGCTTCGGCTTGCTCGACCCCAAGCGAAGACTGAAGACCAGGGGCTGGCGTCGTGTGGGTACCGCAGTCGTGCGCTGGCCCGGGCCAATTCTGGCCACGTCGGTCGCGCTTGCCCTGGTGGGATTGCTCGCACTACCGGGCTACCGGCCCGGCTATAACGATCGCTACTACCTGCGCGCTGGCACGCCTGTCAACCGCGGGTATGCGGCCGCCGACCGGCACTTTGGCCCAGCCCGGATGAACCCCGAGATGCTGCTGGTCGAGAGCGATCAAGACATGCGAAATCCGGCCGGGATGCTCGTCATCGACAAGATCGCCAAGGAGGTCCTGCACGTGTCCGGGGTCGAGCGGGTGCAAGCGATCACCCGGCCGCAGGGGGTGCCCCTTGAGCATGCGTCGATTCCCTTTCAGATCAGCATGATGGGTGCCACCCAGACGATGAGCCTGCCCTACATGCGCGAACGCATGGCCGATATGTTGACCATGAGCGACGAAATGCTGGTTGCGATCAATTCCATGGAACAGATGCTCGACTTGGTGCAGCAGCTCAACGACGTTACCCATGAGATGGCAGCCACGACGCGCGAGATCAAAGCTACTACCAGCGAACTGCGAGATCACCTTGCGGACATCGACGATTTCGTCAGGCCGTTGCGTAGCTATTTCTACTGGGAGCACCATTGCTTCGACATTCCGTTGTGCTCGGCGACGCGATCACTGTTTGACACCCTAGACGGCGTCGACACGCTGACTGACCAATTGCGGGCCCTTACCGACGACATGAATAAGATGGAGGCGCTCACACCGCAATTTCTCGCACTGCTGCCGCCAATGATCACGACCATGAAGACCATGCGGACCATGATGTTGACCATGCGATCAACAATAAGTGGCGTACAAGATCAAATGGCCGATATGCAAGACCATGCGACTGCGATGGGGCAGGCCTTCGACACCGCAAAAAGCGGCGATTCATTCTATCTTCCTCCGGAAGCCTTCGATAATGCAGAATTCCAGCAAGGCATGAAGTTGTTTTTGTCGCCGAATGGTAAGGCGGTGCGCTTCGTAATTTCCCACGAGAGCGATCCAGCAAGTACTGAAGGTATCGATCGCATCGAAGCGATAAGGGCCGCGACCAAAGATGCCATCAAGGCGACACCATTGCAAGGCGCTAAAATCTATATCGGTGGCACGGCTGCGACCTACCAAGACATTCGAGACGGTACCAAGTACGATATCCTCATCGTTGGTATAGCCGCGGTATGCCTGGTATTTATTGTCATGCTCATGATTACCCAGAGCCTGATTGCGTCACTCGTCATTGTTGGCACGGTACTTCTGTCATTGGGTACTGCGTTCGGACTGTCCGTGCTCATCTGGCAGCACTTTGTCGGTCTCCAGGTGCATTGGACGATCGTCGCGATGTCTGTCATCGTCTTGCTGGCCGTCGGTTCTGACTACAACCTCCTTTTGGTGTCCCGGTTCAAGGAGGAGGTCGGCGCTGGATTAAAGACCGGGATCATCCGGGCGATGGCCGGCACCGGCGCAGTTGTCACGTCGGCCGGTCTGGTATTCGCGTTCACCATGGCGTCCATGGCCGTCAGCGAACTCCGCGTTATCGGACAGGTCGGCACCACCATCGGGCTCGGTCTACTTTTCGATACCCTGGTGGTCCGATCGTTCATGACGCCATCCATCGCAGCGCTGCTAGGTCGCTGGTTCTGGTGGCCGAACATGATCCACTCGAGACCCACCGTCCCGGAGGCGCACACACGCCAGGGCGCTCGCCGAATTCAGCCGCATCTGCACCGGGGTTGA
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Unknown

Family

Resistance-nodulation-cell division (RND) (TC 2.A.6) family, MmpL subfamily

GO

cell wall GO:0005618 cellular_component
extracellular region GO:0005576 cellular_component
plasma membrane GO:0005886 cellular_component
active evasion of host immune response GO:0042783 biological_process
integral component of membrane GO:0016021 cellular_component

InterPro

UniProt: P9WJU3
GenBank: Rv2339
EnsemblBacteria: Rv2339
Mycobrowser: Rv2339

Summary

Name: Probable transport protein MmpL9
Family: Resistance-nodulation-cell division (RND) (TC 2.A.6) family, MmpL subfamily
Protein Sequence: MVPGEVHMSDTPSGPHPIIPRTIRLAAIPILLCWLGFTVFVSVAVPPLEAIGETRAVAVAPDDAQSMRAMRRAGKVFNEFDSNSIAMVVLESDQPLGEKAHRYYDHLVDTLVLDQSHIQHIQDFWRDPLTAAGAVSADGKAAYVQLYLAGNMGEALANESVEAVRKIVANSTPPEGIRTYVTGPAALFADQIAAGDRSMKLITGLTFAVITVLLLLVYRSIATTLLILPMVFIGLGATRGTIAFLGYHGMVGLSTFVVNILTALAIAAGTDYAIFLVGRYQEARHIGQNREASFYTMYRGTANVILGSGLTIAGATYCLSFARLTLFHTMGPPLAIGMLVSVAAALTLAPAIIAIAGRFGLLDPKRRLKTRGWRRVGTAVVRWPGPILATSVALALVGLLALPGYRPGYNDRYYLRAGTPVNRGYAAADRHFGPARMNPEMLLVESDQDMRNPAGMLVIDKIAKEVLHVSGVERVQAITRPQGVPLEHASIPFQISMMGATQTMSLPYMRERMADMLTMSDEMLVAINSMEQMLDLVQQLNDVTHEMAATTREIKATTSELRDHLADIDDFVRPLRSYFYWEHHCFDIPLCSATRSLFDTLDGVDTLTDQLRALTDDMNKMEALTPQFLALLPPMITTMKTMRTMMLTMRSTISGVQDQMADMQDHATAMGQAFDTAKSGDSFYLPPEAFDNAEFQQGMKLFLSPNGKAVRFVISHESDPASTEGIDRIEAIRAATKDAIKATPLQGAKIYIGGTAATYQDIRDGTKYDILIVGIAAVCLVFIVMLMITQSLIASLVIVGTVLLSLGTAFGLSVLIWQHFVGLQVHWTIVAMSVIVLLAVGSDYNLLLVSRFKEEVGAGLKTGIIRAMAGTGAVVTSAGLVFAFTMASMAVSELRVIGQVGTTIGLGLLFDTLVVRSFMTPSIAALLGRWFWWPNMIHSRPTVPEAHTRQGARRIQPHLHRG
Mass: 104,613 Da
Length: 962 Aa

Rv2339 doesn't seem to be a targeted by any drug.

Rv2339 doesn't seem to be involved in any pathway.

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.