Gene - combatTB X

dgt

Type: protein_coding
Name: dgt
Locus Name: Rv2344c
Product: Probable deoxyguanosine triphosphate triphosphohydrolase Dgt (dGTPase) (dGTP triphosphohydrolase)
Functional Category: Intermediary metabolism and respiration
Location: 2622457..2623752 (- strand)
Gene Length: 1295 bp
Nucleotides: GTGAGCGCGAGTGAGCACGACCCCTACGACGACTTCGACCGCCAGCGGCGGGTAGCCGAAGCGCCAAAGACTGCCGGTCTGCCGGGCACTGAGGGTCAGTACCGCTCCGACTTCGCCCGGGACCGGGCCCGGGTGCTGCACAGCGCCGCACTGCGCCGGCTAGCCGACAAGACCCAGGTGGTCGGACCCCGGGAAGGGGATACGCCGCGTACCCGGCTGACCCACTCGCTGGAAGTGGCTCAGATCGGACGGGGAATGGCGATCGGGCTGGGCTGCGACCTTGATCTGGTCGAATTGGCCGGTCTAGCCCATGACATCGGGCACCCGCCGTATGGACACAACGGTGAGCGGGCGCTTGATGAAGTCGCAGCCAGCCACGGCGGTTTCGAGGGCAACGCGCAGAACTTCCGTATCTTGACCAGCCTTGAGCCCAAAGTAGTTGACGCACAAGGACTTAGTGCGGGGCTGAACCTAACTCGCGCGTCCCTGGACGCGGTCACCAAGTATCCGTGGATGCGTGGTGACGGGCTTGGCAGCCAGCGGAGGAAGTTCGGCTTCTACGACGACGACCGCGAATCGGCGGTATGGGTTCGGCAAGGCGCGCCCCCGGAGCGGGCGTGCCTGGAAGCGCAGGTGATGGACTGGGCCGACGACGTCGCCTACTCGGTTCACGACGTCGAGGACGGCGTTGTCTCCGAACGCATCGACCTGCGTGTGCTGGCCGCCGAAGAGGACGCTGCCGCGCTGGCCAGGTTAGGGGAGCGCGAGTTCTCCCGGGTGAGCGCCGACGAGTTGATGGCGGCCGCGCGGCGGCTGTCGCGGCTGCCCGTGGTGGCCGCCGTCGGCAAGTATGACGCCACCTTGTCGGCATCGGTCGCGCTCAAGCGGTTGACCAGCGAGCTGGTGGGCCGCTTTGCATCGGCCGCGATCGCGACCACCCGGGCCGCGGCCGGTCCGGGACCGTTGGTGCGCTTCCGGGCCGACCTGCAGGTGCCCGATCTGGTACGTGCCGAGGTCGCGGTACTGAAAATCCTCGCGCTGCAGTTCATCATGTCCGACCCTCGGCATCTGGAAACCCAGGCACGGCAGCGCGAACGTATTCACCGGGTGGCGCACAGGCTGTACTCGGGGGCGCCGCAGACGCTCGACCCGGTTTATGCCGCTGCGTTCAATACCGCCGCCGACGACGCTGCCCGGTTGCGGGTCGTCGTTGATCAGATCGCCTCCTATACCGAGGGTCGGTTGGAACGCATCGATGCCGATCAGCTTGGCGTCAGCAGGAACGCTTTAGACTG
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Unknown

Family

DGTPase family, Type 2 subfamily

GO

plasma membrane GO:0005886 cellular_component
dGTP catabolic process GO:0006203 biological_process
dGTPase activity GO:0008832 molecular_function

InterPro

UniProt: P9WNY7
GenBank: Rv2344c
EnsemblBacteria: Rv2344c
Mycobrowser: Rv2344c

Summary

Name: Deoxyguanosinetriphosphate triphosphohydrolase-like protein
Family: DGTPase family, Type 2 subfamily
Protein Sequence: MSASEHDPYDDFDRQRRVAEAPKTAGLPGTEGQYRSDFARDRARVLHSAALRRLADKTQVVGPREGDTPRTRLTHSLEVAQIGRGMAIGLGCDLDLVELAGLAHDIGHPPYGHNGERALDEVAASHGGFEGNAQNFRILTSLEPKVVDAQGLSAGLNLTRASLDAVTKYPWMRGDGLGSQRRKFGFYDDDRESAVWVRQGAPPERACLEAQVMDWADDVAYSVHDVEDGVVSERIDLRVLAAEEDAAALARLGEREFSRVSADELMAAARRLSRLPVVAAVGKYDATLSASVALKRLTSELVGRFASAAIATTRAAAGPGPLVRFRADLQVPDLVRAEVAVLKILALQFIMSDPRHLETQARQRERIHRVAHRLYSGAPQTLDPVYAAAFNTAADDAARLRVVVDQIASYTEGRLERIDADQLGVSRNALD
Mass: 46,912 Da
Length: 431 Aa

Rv2344c doesn't seem to be a targeted by any drug.

Purine metabolism mtu00230
mtu00230
PATHWAY_MAP mtu00230 Purine metabolism

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.