Rv2345

Type
protein_coding
Name
Rv2345
Locus Name

Rv2345

Product

Possible conserved transmembrane protein

Functional Category

Cell wall and cell processes

Location
2623821..2625803 (+ strand)
Gene Length
1982 bp
Nucleotides
TGCGTCTCGTTCGCCTGCTCGGCATGGTCCTGACTATCCTCGCCGCCGGGCTGCTGCTGGGGCCGCCCGCTGGCGCGCAACCACCTTTCCGGCTGTCGAACTACGTGACCGACAACGCGGGCGTGCTGACTAGCTCCGGTCGCACCGCGGTGACGGCGGCCGTCGACCGGCTCTATGCCGATCGCCGCATCCGACTGTGGGTGGTCTACGTCGAGAACTTCTCCGGTCAGAGTGCGCTCAACTGGGCGCAGCGCACGACGCGGACTAGCGAGCTGGGTAACTATGACGCGCTTCTGGCCGTGGCCACCACCGGTCGCGAATATGCCTTTCTAGTGCCATCCGCGATGCCGGGTGTCAGCGAGGGGCAGGTCGACAACGTGCGGCGCTATCAGATCGAACCGGCGCTGCACGACGGCGACTACAGCGGCGCGGCCGTTGCGGCGGCGAACGGACTCAACCGGTCACCCAGTTCGTCGAGTCGAGTGGTGTTGTTGGTCACGGTCGGCATCATCGTCATCGTCGTCGCGGTCCTGCTGGTGGTGATGCGCCACCGCAACCGGCGGCGCCGCGCCGACGAGCTGGCCGCGGCACGCCGCGTCGACCCTACCAACGTAATGGCACTGGCCGCCGTGCCGCTTCAGGCCCTCGATGACCTCTCCCGGTCGATGGTGGTAGACGTCGACAACGCCGTGCGCACCAGCACCAACGAGCTCGCGCTGGCCATCGAGGAGTTCGGCGAACGGCGAACCGCACCGTTTACCCAAGCGGTGAACAACGCCAAAGCGGCTCTGTCCCAGGCGTTCACCGTACGCCAACAACTTGATGACAACACGCCCGAGACGCCGGCGCAGCGACGTGAGCTACTCACCCGAGTGATCGTGTCGGCGGCGCACGCCGACCGTGAACTCGCGTCGCAAACCGAGGCCTTCGAGAAGCTACGCGATTTGGTGATCAACGCCCCGGCCCGGCTTGATCTGCTCACCCAGCAGTACGTCGAACTGACCACCCGGATCGGCCCGACTCAGCAACGCCTGGCCGAGCTGCATACCGAATTCGACGCTGCGGCGATGACGTCGATCGCCGGCAATGTCACCACCGCCACCGAGCGGCTGGCGTTCGCCGACCGTAACATCAGCGCGGCTCGGGATCTGGCCGACCAGGCAGTGAGCGGACGGCAAGCCGGACTGGTGGATGCGGTGCGTGCCGCCGAGTCGGCACTCGGGCAAGCCCGGGCGCTGCTCGACGCGGTGGACAGCGCCGCCACCGACATCCGGCACGCCGTCGCGTCGCTGCCGGCGGTCGTGGCCGACATCCAGACGGGCATCAAGCGAGCCAACCAACACCTACAGCAGGCGCAACAACCCCAAACCGGGCGCACCGGTGACCTGATCGCAGCCCGCGATGCGGCGGCCAGGGCCCTCGATCGCGCGCGCGGAGCCGCCGATCCGTTGACCGCATTTGACCAGTTGACCAAGGTCGACGCTGACCTCGACCGGCTGCTCGCCACCCTGGCCGAAGAACAGGCAACCGCCGATCGGCTCAACCGCTCACTTGAGCAGGCGCTGTTTACCGCGGAGTCGCGGGTGCGCGCCGTCTCGGAGTACATCGACACCCGCCGCGGCAGCATCGGGCCGGAGGCCCGGACCCGGCTGGCCGAGGCGAAACGGCAGCTGGAAGCCGCACATGACCGGAAATCGAGCAACCCGACCGAAGCGATCGCCTACGCTAACGCGGCATCGACGCTGGCCGCACATGCGCAGTCGCTGGCCAATGCCGACGTGCAATCCGCCCAGCGCGCATACACCCGTCGTGGGGGCAACAACGCCGGCGCGATCCTCGGTGGCATCATCATCGGCGACCTGCTTAGCGGAGGCACCAGAGGCGGGTTGGGTGGATGGATCCCCACGTCGTTCGGCGGTTCGTCGAACGCGCCGGGAAGTTCACCCGACGGCGGGTTCTTGGGCGGCGGCGGGCGGTTCTAA
Drug Resistance

Check for drug resistance association at TBDREAMDB

Mutations

Check for mutants available at TARGET

Function
May play a role in septum formation. {ECO:0000269|PubMed:16735741}.
Family

UPF0603 family

GO
InterPro
UniProt
P9WFJ5
GenBank
Rv2345
EnsemblBacteria
Rv2345
Mycobrowser
Rv2345
Summary
Name
UPF0603 protein Rv2345
Family
UPF0603 family
Protein Sequence
MRLVRLLGMVLTILAAGLLLGPPAGAQPPFRLSNYVTDNAGVLTSSGRTAVTAAVDRLYADRRIRLWVVYVENFSGQSALNWAQRTTRTSELGNYDALLAVATTGREYAFLVPSAMPGVSEGQVDNVRRYQIEPALHDGDYSGAAVAAANGLNRSPSSSSRVVLLVTVGIIVIVVAVLLVVMRHRNRRRRADELAAARRVDPTNVMALAAVPLQALDDLSRSMVVDVDNAVRTSTNELALAIEEFGERRTAPFTQAVNNAKAALSQAFTVRQQLDDNTPETPAQRRELLTRVIVSAAHADRELASQTEAFEKLRDLVINAPARLDLLTQQYVELTTRIGPTQQRLAELHTEFDAAAMTSIAGNVTTATERLAFADRNISAARDLADQAVSGRQAGLVDAVRAAESALGQARALLDAVDSAATDIRHAVASLPAVVADIQTGIKRANQHLQQAQQPQTGRTGDLIAARDAAARALDRARGAADPLTAFDQLTKVDADLDRLLATLAEEQATADRLNRSLEQALFTAESRVRAVSEYIDTRRGSIGPEARTRLAEAKRQLEAAHDRKSSNPTEAIAYANAASTLAAHAQSLANADVQSAQRAYTRRGGNNAGAILGGIIIGDLLSGGTRGGLGGWIPTSFGGSSNAPGSSPDGGFLGGGGRF
Mass
70,030 Da
Length
660 Aa

Rv2345 doesn't seem to be a targeted by any drug.

Rv2345 doesn't seem to be involved in any pathway.

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Identification of cell cycle regulators in Mycobacterium tuberculosis by inhibition of septum formation and global transcriptional analysis.
Microbiology. 2006 Jun;152(Pt 6):1789-97. doi: 10.1099/mic.0.28762-0.
Genes required for mycobacterial growth defined by high density mutagenesis.
Mol Microbiol. 2003 Apr;48(1):77-84.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.