Gene - combatTB X

Rv2372c

Type: protein_coding
Name: Rv2372c
Locus Name: Rv2372c
Product: Conserved hypothetical protein
Functional Category: Conserved hypotheticals
Location: 2652037..2652825 (- strand)
Gene Length: 788 bp
Nucleotides: ATGGTGGCGATGCTGTTTTACGTCGACACACTGCCCGACACCGGTGCGGTGGCGGTCGTAGACGGCGACGAAGGATTTCACGCCGCCACCGTGCGGCGGATCCGTCCCGGCGAGCAGTTGGTGCTTGGTGACGGTGTCGGTCGCCTGGCCCGCTGTGTGGTGGAGCAGGCCGGACGTGGCGGGCTGCGGGCCCGGGTGCTTAGGCGCTGGAGCGTCCCGCCCGTGCGGCCACCGGTGACCGTGGTGCAGGCGCTGCCCAAATCCGAACGCTCCGAATTGGCAATCGAGCTGGCCACCGAAGCCGGAGCCGACGCGTTCCTGGCATGGCAGGCGGCGCGCTGCGTGGCGAACTGGGACGGGGCGCGTGTCGACAAGGGTTTGCGTCGGTGGCGAGCGGTGGTCCGCTCGGCGGCCCGGCAATCTCGTCGGGCGCGCATCCCGCCGGTCGACGGCGTGTTGTCGACGCCAATGCTTGTACAGCGTGTCCGAGAAGAGGTGGCCGCCGGCGCGGCGGTGCTGGTCCTGCACGAGGAGGCGACCGAGCGGATTGTGGATATCGCTGCGGCGCAAGCTGGTTCGTTGATGCTCGTGGTTGGACCCGAGGGTGGGATCGCACCGGACGAGCTTGCCGCGCTGACCGATGCCGGCGCCGTCGCGGTCCGGCTGGGCCCGACGGTGCTGCGGACATCGACCGCGGCCGCGGTGGCATTGGGTGCTGTCGGTGTGCTCACATCTCGTTGGGATGCATCAGCGAGCGACTGTGAATACTGCGACGTGACACGCCGGTA
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity). {ECO:0000250}.

Family

RNA methyltransferase RsmE family

GO

rRNA base methylation GO:0070475 biological_process
cytoplasm GO:0005737 cellular_component
rRNA (uridine-N3-)-methyltransferase activity GO:0070042 molecular_function

InterPro

UniProt: P9WGX1
GenBank: Rv2372c
EnsemblBacteria: Rv2372c
Mycobrowser: Rv2372c

Summary

Name: Ribosomal RNA small subunit methyltransferase E (EC 2.1.1.193) (16S rRNA m3U1498 methyltransferase)
Family: RNA methyltransferase RsmE family
Protein Sequence: MVAMLFYVDTLPDTGAVAVVDGDEGFHAATVRRIRPGEQLVLGDGVGRLARCVVEQAGRGGLRARVLRRWSVPPVRPPVTVVQALPKSERSELAIELATEAGADAFLAWQAARCVANWDGARVDKGLRRWRAVVRSAARQSRRARIPPVDGVLSTPMLVQRVREEVAAGAAVLVLHEEATERIVDIAAAQAGSLMLVVGPEGGIAPDELAALTDAGAVAVRLGPTVLRTSTAAAVALGAVGVLTSRWDASASDCEYCDVTRR
Mass: 27,653 Da
Length: 262 Aa

Rv2372c doesn't seem to be a targeted by any drug.

Rv2372c doesn't seem to be involved in any pathway.

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
targetTB: a target identification pipeline for Mycobacterium tuberculosis through an interactome, reactome and genome-scale structural analysis.: BMC Syst Biol. 2008 Dec 19;2:109. doi: 10.1186/1752-0509-2-109.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.