Function

Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity). Inhibits the beta-lactamase and RNase activity of RNase J. {ECO:0000255|HAMAP-Rule:MF_01152, ECO:0000269|PubMed:21568871}.

Family

DnaJ family

GO

• chaperone cofactor-dependent protein refolding GO:0051085 biological_process
• unfolded protein binding GO:0051082 molecular_function
• zinc ion binding GO:0008270 molecular_function
• cytoplasm GO:0005737 cellular_component
• DNA replication GO:0006260 biological_process
• ATP binding GO:0005524 molecular_function
• cell wall GO:0005618 cellular_component
• protein refolding GO:0042026 biological_process
• heat shock protein binding GO:0031072 molecular_function
• response to heat GO:0009408 biological_process

InterPro

• IPR012724
• IPR002939
• IPR001623
• IPR008971
• IPR001305
• IPR036410
• IPR036869

UniProt

P9WNV7

GenBank

Rv2373c

EnsemblBacteria

Rv2373c

Mycobrowser

Rv2373c

Rv2373c doesn't seem to be a targeted by any drug.

Rv2373c doesn't seem to be involved in any pathway.