Gene - combatTB X

Type: protein_coding
Name: cfp2
Locus Name: Rv2376c
Product: Low molecular weight antigen CFP2 (low molecular weight protein antigen 2) (CFP-2)
Functional Category: Cell wall and cell processes
Location: 2655609..2656115 (- strand)
Gene Length: 506 bp
Nucleotides: ATGAAGATGGTGAAATCGATCGCCGCAGGTCTGACCGCCGCGGCTGCAATCGGCGCCGCTGCGGCCGGTGTGACTTCGATCATGGCTGGCGGCCCGGTCGTATACCAGATGCAGCCGGTCGTCTTCGGCGCGCCACTGCCGTTGGACCCGGCATCCGCCCCTGACGTCCCGACCGCCGCCCAGTTGACCAGCCTGCTCAACAGCCTCGCCGATCCCAACGTGTCGTTTGCGAACAAGGGCAGTCTGGTCGAGGGCGGCATCGGGGGCACCGAGGCGCGCATCGCCGACCACAAGCTGAAGAAGGCCGCCGAGCACGGGGATCTGCCGCTGTCGTTCAGCGTGACGAACATCCAGCCGGCGGCCGCCGGTTCGGCCACCGCCGACGTTTCCGTCTCGGGTCCGAAGCTCTCGTCGCCGGTCACGCAGAACGTCACGTTCGTGAATCAAGGCGGCTGGATGCTGTCACGCGCATCGGCGATGGAGTTGCTGCAGGCCGCAGGGAACTG
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

May play a role in the development of protective immune responses.

Family

MTB12 family

GO

InterPro

Summary

Name: Low molecular weight antigen MTB12 (CFP-2) (Low molecular weight protein antigen 2)
Family: MTB12 family
Protein Sequence: MKMVKSIAAGLTAAAAIGAAAAGVTSIMAGGPVVYQMQPVVFGAPLPLDPASAPDVPTAAQLTSLLNSLADPNVSFANKGSLVEGGIGGTEARIADHKLKKAAEHGDLPLSFSVTNIQPAAAGSATADVSVSGPKLSSPVTQNVTFVNQGGWMLSRASAMELLQAAGN
Mass: 16,635 Da
Length: 168 Aa

Rv2376c doesn't seem to be a targeted by any drug.

Rv2376c doesn't seem to be involved in any pathway.

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Isolation, purification and immunological characterization of novel low molecular weight protein antigen CFP 6 from culture filtrate of M. tuberculosis.: Vaccine. 2000 Jun 15;18(25):2856-66.
Molecular cloning, expression, and immunogenicity of MTB12, a novel low-molecular-weight antigen secreted by Mycobacterium tuberculosis.: Infect Immun. 1998 Sep;66(9):4208-14.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.