mbtG
- Type
- protein_coding
- Name
- mbtG
- Locus Name
-
Rv2378c
- Product
-
Lysine-N-oxygenase MbtG (L-lysine 6-monooxygenase) (lysine N6-hydroxylase)
- Functional Category
-
Lipid metabolism
- Location
- 2656408..2657703 (- strand)
- Gene Length
- 1295 bp
- Nucleotides
-
ATGAATCCGACGCTCGCGGTCCTGGGCGCTGGAGCCAAGGCGGTGGCGGTCGCGGCCAAGGCATCCGTGCTGCGTGACATGGGGGTCGACGTGCCCGACGTGATCGCCGTCGAACGCATCGGGGTCGGGGCCAACTGGCAGGCCAGCGGTGGCTGGACCGACGGAGCCCACCGGCTGGGCACCAGCCCAGAAAAGGATGTCGGTTTTCCCTACCGGTCGGCGCTGGTGCCACGGCGCAACGCAGAATTGGACGAGCGGATGACCCGCTACAGCTGGCAGTCGTATCTGATCGCCACCGCGTCGTTCGCGGAATGGATCGACCGGGGCCGCCCGGCGCCCACCCATCGCAGGTGGAGTCAGTACCTAGCCTGGGTGGCCGATCACATTGGCCTCAAGGTGATCCACGGCGAGGTCGAACGGCTCGCCGTCACCGGTGACCGCTGGGCGTTGTGCACCCACGAGACCACCGTGCAGGCCGACGCGTTGATGATCACCGGGCCCGGCCAGGCTGAAAAGTCGCTACTGCCCGGAAACCCGCGCGTGCTCTCAATCGCACAGTTCTGGGACCGTGCCGCCGGCCACGACCGGATCAACGCCGAGCGGGTCGCGGTGATCGGTGGCGGAGAGACGGCCGCATCGATGCTCAACGAGCTGTTCCGGCATCGGGTCTCAACCATCACCGTCATCTCCCCGCAGGTAACCCTGTTCACCCGCGGCGAGGGATTCTTCGAGAACTCACTGTTTTCCGATCCGACCGACTGGGCGGCCTTGACGTTCGACGAACGGCGCGACGCGCTGGCCCGCACCGACCGAGGAGTGTTCTCGGCGACCGTGCAGGAAGCGCTGCTGGCCGATGACCGCATCCATCATCTGCGTGGCCGGGTCGCCCACGCGGTGGGCCGTCAGGGGCAGATCCGGTTGACGCTGAGCACCAACCGGGGCAGCGAGAACTTCGAGACCGTGCACGGATTCGATCTCGTCATCGACGGCTCGGGCGCCGATCCGCTGTGGTTCACCTCACTGTTCAGTCAGCACACCCTCGACCTGCTCGAGCTGGGACTGGGTGGACCGCTGACCGCCGACCGCCTGCAGGAAGCGATCGGCTACGACTTGGCAGTCACCGACGTCACGCCCAAGCTGTTCCTGCCCACCCTGTCCGGACTCACCCAGGGGCCCGGGTTCCCCAACCTGAGCTGCCTCGGCTTGTTGTCGGACCGGGTGCTCGGCGCCGGCATCTTTACGCCGACCAAACACAACGACACAAGGAGAAGCGGTGAGCACCAATCCTTTCGATG
- Drug Resistance
- Mutations
- Function
- Flavoprotein monooxygenase required for N-hydroxylation of the two acylated lysine residues during mycobactin assembly, thus producing the hydroxamate groups necessary for iron sequestration. Is also able, but less efficiently, to hydroxylate L-lysine (non acylated) in vitro. {ECO:0000269|PubMed:16461464}.
- Family
-
Lysine N(6)-hydroxylase/L-ornithine N(5)-oxygenase family
- GO
-
- siderophore biosynthetic process from catechol GO:0019540 biological_process
- L-lysine 6-monooxygenase (NADPH) activity GO:0047091 molecular_function
- InterPro
Summary
- Name
- L-lysine N6-monooxygenase MbtG (EC 1.14.13.59) (Lysine 6-N-hydroxylase) (Lysine N6-hydroxylase) (Lysine-N-oxygenase) (Mycobactin synthase protein G)
- Family
- Lysine N(6)-hydroxylase/L-ornithine N(5)-oxygenase family
- Protein Sequence
-
MNPTLAVLGAGAKAVAVAAKASVLRDMGVDVPDVIAVERIGVGANWQASGGWTDGAHRLGTSPEKDVGFPYRSALVPRRNAELDERMTRYSWQSYLIATASFAEWIDRGRPAPTHRRWSQYLAWVADHIGLKVIHGEVERLAVTGDRWALCTHETTVQADALMITGPGQAEKSLLPGNPRVLSIAQFWDRAAGHDRINAERVAVIGGGETAASMLNELFRHRVSTITVISPQVTLFTRGEGFFENSLFSDPTDWAALTFDERRDALARTDRGVFSATVQEALLADDRIHHLRGRVAHAVGRQGQIRLTLSTNRGSENFETVHGFDLVIDGSGADPLWFTSLFSQHTLDLLELGLGGPLTADRLQEAIGYDLAVTDVTPKLFLPTLSGLTQGPGFPNLSCLGLLSDRVLGAGIFTPTKHNDTRRSGEHQSFR
- Mass
- 46,944 Da
- Length
- 431 Aa
Rv2378c doesn't seem to be a targeted by any drug.
Rv2378c doesn't seem to be involved in any pathway.
- Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
- Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
- A genetic locus required for iron acquisition in Mycobacterium tuberculosis.
- Proc Natl Acad Sci U S A. 2006 Feb 14;103(7):2069-74. doi: 10.1073/pnas.0507924103. Epub 2006 Feb 3.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.