hemN
- Type
- protein_coding
- Name
- hemN
- Locus Name
-
Rv2388c
- Product
-
Probable oxygen-independent coproporphyrinogen III oxidase HemN (coproporphyrinogenase) (coprogen oxidase)
- Functional Category
-
Intermediary metabolism and respiration
- Location
- 2682015..2683142 (- strand)
- Gene Length
- 1127 bp
- Nucleotides
-
ATGCCCGGACAACCGTTCGGGGTCTACCTGCACGTCCCGTTCTGCCTGACCCGTTGCGGGTACTGCGACTTCAATACCTACACCCCGGCCCAGCTGGGTGGCGTCAGCCCGGACCGTTGGCTGCTGGCGCTGCGGGCGGAGCTCGAACTGGCGGCCGCCAAGCTGGACGCACCGACGGTGCATACCGTGTATGTGGGTGGCGGGACGCCATCGCTGCTCGGGGGGGAGCGCCTGGCCACGTTGCTGGACATGGTGCGGGACCACTTTGTGCTGGCGCCCGACGCCGAAGTCAGCACCGAGGCCAACCCCGAGTCGACGTGGCCGGAGTTCTTCGCCACGATCCGCGCGGCCGGTTACACGCGGGTGTCGCTCGGCATGCAGTCGGTGGCCCCGAGGGTGCTGGCAACCTTGGACCGGGTGCACTCGCCGGGCCGGGCGGCGGCCGCGGCCACCGAGGCGATAGCGGAGGGCTTCACACACGTCAACCTCGACCTGATCTATGGAACCCCGGGGGAGTCCGACGACGACCTGGTGCGCTCAGTGGACGCCGCGGTGCAGGCCGGTGTGGATCATGTGTCCGCGTATGCCTTGGTCGTCGAGCACGGCACGGCACTGGCTCGCCGGGTTCGGCGTGGTGAGCTGGCCGCGCCCGATGACGACGTGCTGGCGCATCGCTACGAGTTGGTCGATGCTCGGCTGTCGGCGGCCGGGTTTGCCTGGTACGAGGTGTCCAATTGGTGTCGACCGGGCGGCGAGTGCCGGCACAACCTGGGTTATTGGGACGGTGGCCAGTGGTGGGGCGCAGGTCCGGGCGCGCACGGCTACATTGGCGTGACACGCTGGTGGAATGTCAAGCACCCCAACACTTACGCCGAGATACTGGCCGGGGCGACGTTGCCGGTAGCGGGCTTCGAGCAGCTGGGCGCCGACGCTTTGCACACCGAAGACGTGTTGCTGAAGGTCCGGCTGCGCCAGGGGCTACCGCTCGCCCGGCTAGGGGCTGCCGAACGGGAACGTGCCGAGGCGGTGTTGGCCGACGGATTGCTGGACTACCACGGCGACCGACTGGTCCTCACCGGCCGGGGGCGATTGCTGGCCGACGCGGTGGTGCGCACTCTGCTGGGCTA
- Drug Resistance
- Mutations
- Function
- Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently (By similarity). Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine (By similarity). {ECO:0000250|UniProtKB:P32131, ECO:0000250|UniProtKB:P52062}.
- Family
-
Anaerobic coproporphyrinogen-III oxidase family, HemW subfamily
- GO
-
- metal ion binding GO:0046872 molecular_function
- cytoplasm GO:0005737 cellular_component
- 4 iron, 4 sulfur cluster binding GO:0051539 molecular_function
- porphyrin-containing compound biosynthetic process GO:0006779 biological_process
- coproporphyrinogen oxidase activity GO:0004109 molecular_function
- InterPro
Summary
- Name
- Heme chaperone HemW (Oxygen-independent coproporphyrinogen-III oxidase-like protein Rv2388c)
- Family
- Anaerobic coproporphyrinogen-III oxidase family, HemW subfamily
- Protein Sequence
-
MPGQPFGVYLHVPFCLTRCGYCDFNTYTPAQLGGVSPDRWLLALRAELELAAAKLDAPTVHTVYVGGGTPSLLGGERLATLLDMVRDHFVLAPDAEVSTEANPESTWPEFFATIRAAGYTRVSLGMQSVAPRVLATLDRVHSPGRAAAAATEAIAEGFTHVNLDLIYGTPGESDDDLVRSVDAAVQAGVDHVSAYALVVEHGTALARRVRRGELAAPDDDVLAHRYELVDARLSAAGFAWYEVSNWCRPGGECRHNLGYWDGGQWWGAGPGAHGYIGVTRWWNVKHPNTYAEILAGATLPVAGFEQLGADALHTEDVLLKVRLRQGLPLARLGAAERERAEAVLADGLLDYHGDRLVLTGRGRLLADAVVRTLLG
- Mass
- 40,334 Da
- Length
- 375 Aa
Rv2388c doesn't seem to be a targeted by any drug.
Rv2388c doesn't seem to be involved in any pathway.
- Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
- Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
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- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.