Gene - combatTB X

Type: protein_coding
Name: cysA1
Locus Name: Rv2397c
Product: Sulfate-transport ATP-binding protein ABC transporter CysA1
Functional Category: Cell wall and cell processes
Location: 2693909..2694964 (- strand)
Gene Length: 1055 bp
Nucleotides: ATGACCTACGCCATCGTCGTGGCCGACGCCACCAAACGCTACGGCGACTTCGTCGCACTTGACCACGTGGATTTCGTCGTACCGACCGGTTCGCTGACCGCATTGTTGGGCCCCAGCGGTTCGGGCAAGTCGACGCTGTTGCGCACCATAGCCGGCCTCGACCAACCGGACACCGGAACCATCACGATCAACGGCCGCGACGTCACCCGGGTGCCGCCACAGCGGCGTGGCATCGGATTCGTCTTCCAGCACTACGCGGCGTTCAAACACCTGACTGTCCGTGACAACGTGGCGTTCGGGTTGAAGATCCGTAAGCGCCCCAAGGCCGAGATCAAGGCCAAGGTCGACAATCTGCTGCAGGTGGTGGGCCTGAGCGGATTTCAGAGCCGCTACCCCAATCAGCTCTCCGGTGGGCAACGACAGCGGATGGCGCTGGCCAGGGCGCTGGCGGTCGATCCGGAGGTGCTGCTGCTCGACGAGCCGTTCGGCGCACTCGATGCCAAGGTGCGCGAAGAGCTGCGTGCCTGGCTGCGCCGCCTGCACGACGAGGTGCATGTCACCACGGTGCTGGTCACCCACGATCAGGCCGAAGCGCTGGATGTGGCCGACCGCATCGCCGTACTCCACAAGGGCCGTATCGAGCAGGTCGGATCCCCGACCGACGTTTACGACGCCCCGGCGAACGCCTTCGTGATGTCCTTCTTGGGAGCGGTTTCCACGTTGAACGGCTCCCTGGTGCGCCCGCACGACATCCGGGTCGGCCGGACTCCCAATATGGCCGTGGCCGCCGCTGACGGCACCGCCGGGTCCACCGGTGTGCTACGGGCTGTTGTGGATCGGGTGGTGGTGCTGGGCTTCGAGGTCCGCGTGGAGTTGACCAGCGCGGCCACCGGCGGGGCCTTCACCGCCCAGATCACCCGCGGCGATGCCGAGGCGCTGGCCCTACGCGAGGGTGACACCGTCTACGTGCGTGCCACCCGGGTGCCGCCGATTGCCGGTGGCGTATCGGGCGTCGACGATGCCGGCGTGGAACGGGTCAAAGTCACATCGACGTG
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Part of the ABC transporter complex CysAWTP involved in sulfate/thiosulfate import. Responsible for energy coupling to the transport system.

Family

ABC transporter superfamily, Sulfate/tungstate importer (TC 3.A.1.6) family

GO

sulfate assimilation GO:0000103 biological_process
sulfate transport GO:0008272 biological_process
plasma membrane GO:0005886 cellular_component
ATP-binding cassette (ABC) transporter complex GO:0043190 cellular_component
ATP binding GO:0005524 molecular_function
ATPase-coupled sulfate transmembrane transporter activity GO:0015419 molecular_function

InterPro

Summary

Name: Sulfate/thiosulfate import ATP-binding protein CysA (EC 7.3.2.3) (Sulfate-transporting ATPase)
Family: ABC transporter superfamily, Sulfate/tungstate importer (TC 3.A.1.6) family
Protein Sequence: MTYAIVVADATKRYGDFVALDHVDFVVPTGSLTALLGPSGSGKSTLLRTIAGLDQPDTGTITINGRDVTRVPPQRRGIGFVFQHYAAFKHLTVRDNVAFGLKIRKRPKAEIKAKVDNLLQVVGLSGFQSRYPNQLSGGQRQRMALARALAVDPEVLLLDEPFGALDAKVREELRAWLRRLHDEVHVTTVLVTHDQAEALDVADRIAVLHKGRIEQVGSPTDVYDAPANAFVMSFLGAVSTLNGSLVRPHDIRVGRTPNMAVAAADGTAGSTGVLRAVVDRVVVLGFEVRVELTSAATGGAFTAQITRGDAEALALREGDTVYVRATRVPPIAGGVSGVDDAGVERVKVTST
Mass: 37,444 Da
Length: 351 Aa

Rv2397c doesn't seem to be a targeted by any drug.

ABC transporters mtu02010
mtu02010
Environmental Information Processing; Membrane transport

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Functional genomics reveals the sole sulphate transporter of the Mycobacterium tuberculosis complex and its relevance to the acquisition of sulphur in vivo.: Mol Microbiol. 2002 Feb;43(3):653-63.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.