Gene - combatTB X

Type: protein_coding
Name: cysT
Locus Name: Rv2399c
Product: Probable sulfate-transport integral membrane protein ABC transporter CysT
Functional Category: Cell wall and cell processes
Location: 2695796..2696647 (- strand)
Gene Length: 851 bp
Nucleotides: ATGACGGAATCGTTGGTCGGCGAACGCCGCGCGCCGCAGTTCCGCGCGCGCCTTTCCGGCCCCGCGGGCCCCCCTTCCGTTCGGGTCGGTATGGCAGTGGTGTGGCTTTCGGTGATCGTGCTGTTGCCGCTGGCCGCCATCGTCTGGCAGGCCGCGGGCGGTGGTTGGCGGGCCTTCTGGCTGGCGGTCTCGTCGCATGCCGCGATGGAGTCGTTCCGGGTAACGCTGACGATTTCGACCGCAGTCACGGTCATCAACCTGGTGTTCGGCTTGCTGATCGCCTGGGTGCTGGTGCGTGACGACTTCGCTGGCAAGCGGATCGTCGATGCGATTATCGATCTGCCGTTTGCGTTGCCCACCATCGTCGCCAGCCTGGTGATGTTGGCACTGTACGGGAACAACAGCCCGGTGGGGCTTCATTTTCAACACACCGCGACCGGTGTTGGGGTGGCGTTGGCGTTCGTCACATTGCCGTTCGTGGTGCGCGCCGTGCAGCCGGTGCTGCTGGAAATCGATCGCGAGACCGAGGAGGCGGCGGCGTCGCTGGGCGCTAATGGTGCCAAAATCTTCACTTCGGTGGTGTTGCCGTCGCTGACGCCGGCATTGTTATCCGGTGCGGGCCTGGCGTTTTCGCGCGCTATCGGCGAGTTCGGTTCGGTGGTTCTGATCGGCGGGGCCGTGCCGGGCAAGACCGAGGTGTCCTCGCAATGGATTCGCACCCTGATCGAGAACGACGACCGCACCGGAGCGGCCGCGATATCGGTTGTATTGCTCTCGATTTCGTTCATTGTGCTGCTCATCCTACGTGTCGTCGGCGCGCGTGCGGCCAAACGTGAGGAGATGGCCGCATG
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Part of the ABC transporter complex (TC 3.A.1.6.1) involved in sulfate/thiosulfate import. {ECO:0000256|RuleBase:RU366001}.

Family

Binding-protein-dependent transport system permease family, CysTW subfamily

GO

ATPase-coupled sulfate transmembrane transporter activity GO:0015419 molecular_function
plasma membrane GO:0005886 cellular_component
sulfate assimilation GO:0000103 biological_process
integral component of membrane GO:0016021 cellular_component

InterPro

Summary

Name: Sulfate transport system permease protein CysT
Family: Binding-protein-dependent transport system permease family, CysTW subfamily
Protein Sequence: MTESLVGERRAPQFRARLSGPAGPPSVRVGMAVVWLSVIVLLPLAAIVWQAAGGGWRAFWLAVSSHAAMESFRVTLTISTAVTVINLVFGLLIAWVLVRDDFAGKRIVDAIIDLPFALPTIVASLVMLALYGNNSPVGLHFQHTATGVGVALAFVTLPFVVRAVQPVLLEIDRETEEAAASLGANGAKIFTSVVLPSLTPALLSGAGLAFSRAIGEFGSVVLIGGAVPGKTEVSSQWIRTLIENDDRTGAAAISVVLLSISFIVLLILRVVGARAAKREEMAA
Mass: 29,683 Da
Length: 283 Aa

Rv2399c doesn't seem to be a targeted by any drug.

ABC transporters mtu02010
mtu02010
Environmental Information Processing; Membrane transport

Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.