Gene - combatTB X

obg

Type: protein_coding
Name: obg
Locus Name: Rv2440c
Product: Probable GTP1/Obg-family GTP-binding protein Obg
Functional Category: Intermediary metabolism and respiration
Location: 2738247..2739686 (- strand)
Gene Length: 1439 bp
Nucleotides: GTGCCTCGGTTTGTCGATCGGGTCGTCATCCACACCAGAGCGGGTTCGGGCGGTAACGGCTGCGCTTCGGTCCATCGCGAGAAATTCAAGCCGCTGGGCGGCCCCGATGGCGGAAATGGCGGCCGGGGCGGCAGCATCGTCTTCGTCGTCGATCCGCAAGTGCACACCCTGCTCGACTTCCATTTCCGCCCGCATCTCACCGCGGCTTCGGGCAAGCACGGGATGGGCAATAACCGCGACGGGGCCGCCGGCGCGGATTTGGAAGTGAAAGTTCCCGAAGGCACCGTGGTATTGGACGAGAACGGCCGGCTACTGGCCGACCTGGTCGGCGCGGGCACCCGCTTTGAAGCCGCCGCCGGAGGCCGTGGCGGTTTGGGCAACGCCGCGCTGGCTTCCCGCGTGCGTAAGGCCCCCGGTTTCGCACTCCTCGGCGAAAAGGGACAGTCCCGAGACCTCACCTTGGAACTCAAGACCGTCGCCGACGTCGGCCTGGTCGGGTTTCCGTCGGCCGGAAAATCCTCGCTGGTGTCGGCGATTTCGGCGGCCAAGCCGAAGATCGCCGACTACCCGTTCACCACCCTGGTGCCCAACCTCGGTGTGGTCTCGGCTGGCGAGCACGCGTTCACCGTCGCCGACGTGCCGGGGTTGATCCCGGGCGCATCCCGGGGCCGTGGTCTGGGGCTGGACTTTCTGCGGCACATCGAGCGCTGCGCTGTACTGGTGCATGTGGTGGATTGCGCTACCGCCGAGCCGGGCCGCGACCCCATCTCGGACATCGACGCGCTGGAAACGGAACTCGCGTGCTACACGCCCACGCTGCAAGGGGACGCGGCTCTGGGCGATCTCGCCGCACGGCCGCGTGCGGTGGTCCTCAACAAAATCGATGTGCCGGAGGCCCGCGAGCTCGCGGAGTTCGTCCGTGACGACATCGCCCAGCGCGGCTGGCCGGTGTTCTGCGTGTCGACCGCAACCCGGGAAAACCTGCAGCCGTTGATCTTTGGGCTGTCGCAGATGATCTCGGACTACAACGCTGCGCGGCCGGTGGCGGTGCCACGGCGGCCGGTGATTCGTCCGATTCCGGTGGACGACAGCGGTTTTACCGTCGAACCCGACGGGCATGGTGGCTTTGTCGTCAGCGGTGCCCGGCCCGAGCGTTGGATTGACCAGACCAACTTCGACAACGACGAGGCCGTCGGCTATCTCGCCGACCGGCTGGCGCGCCTGGGTGTCGAGGAGGAATTGCTGAGGCTGGGTGCGCGGTCAGGATGCGCGGTGACCATCGGCGAGATGACGTTCGATTGGGAGCCGCAAACGCCTGCGGGTGAGCCGGTCGCGATGTCCGGCCGGGGCACCGATCCGCGGCTGGACAGCAACAAGCGGGTGGGCGCGGCCGAGCGAAAGGCCGCTCGGAGTCGGCGTCGCGAACACGGGGATGGCTG
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control (By similarity). GTPase activity is not inhibited by ATP or GDP. Overexpression decreases cell growth starting in late log phase and continuing into stationary phase (PubMed:21352546). {ECO:0000255|HAMAP-Rule:MF_01454, ECO:0000269|PubMed:21352546}.

Family

TRAFAC class OBG-HflX-like GTPase superfamily, OBG GTPase family

GO

protein autophosphorylation GO:0046777 biological_process
magnesium ion binding GO:0000287 molecular_function
GTPase activity GO:0003924 molecular_function
ribosome biogenesis GO:0042254 biological_process
GTP binding GO:0005525 molecular_function
ribosome GO:0005840 cellular_component
plasma membrane GO:0005886 cellular_component

InterPro

UniProt: P9WMT1
GenBank: Rv2440c
EnsemblBacteria: Rv2440c
Mycobrowser: Rv2440c

Summary

Name: GTPase Obg (EC 3.6.5.-) (GTP-binding protein Obg)
Family: TRAFAC class OBG-HflX-like GTPase superfamily, OBG GTPase family
Protein Sequence: MPRFVDRVVIHTRAGSGGNGCASVHREKFKPLGGPDGGNGGRGGSIVFVVDPQVHTLLDFHFRPHLTAASGKHGMGNNRDGAAGADLEVKVPEGTVVLDENGRLLADLVGAGTRFEAAAGGRGGLGNAALASRVRKAPGFALLGEKGQSRDLTLELKTVADVGLVGFPSAGKSSLVSAISAAKPKIADYPFTTLVPNLGVVSAGEHAFTVADVPGLIPGASRGRGLGLDFLRHIERCAVLVHVVDCATAEPGRDPISDIDALETELACYTPTLQGDAALGDLAARPRAVVLNKIDVPEARELAEFVRDDIAQRGWPVFCVSTATRENLQPLIFGLSQMISDYNAARPVAVPRRPVIRPIPVDDSGFTVEPDGHGGFVVSGARPERWIDQTNFDNDEAVGYLADRLARLGVEEELLRLGARSGCAVTIGEMTFDWEPQTPAGEPVAMSGRGTDPRLDSNKRVGAAERKAARSRRREHGDG
Mass: 50,461 Da
Length: 479 Aa

Rv2440c doesn't seem to be a targeted by any drug.

Rv2440c doesn't seem to be involved in any pathway.

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Biochemical and physiological characterization of the GTP-binding protein Obg of Mycobacterium tuberculosis.: BMC Microbiol. 2011 Feb 25;11:43. doi: 10.1186/1471-2180-11-43.
Cloning and characterization of GTP-binding proteins of Mycobacterium tuberculosis H(37)Rv.: Enzyme Microb Technol. 2008 Jan;42(2):138-44. doi: 10.1016/j.enzmictec.2007.08.008. Epub 2007 Sep 1.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.