Gene - combatTB X

dctA

Type: protein_coding
Name: dctA
Locus Name: Rv2443
Product: Probable C4-dicarboxylate-transport transmembrane protein DctA
Functional Category: Cell wall and cell processes
Location: 2740709..2742184 (+ strand)
Gene Length: 1475 bp
Nucleotides: TGACCGCCCCCTTGGATCGTGCGCCGGTCACGGATTTGCCGGCTAACAACAAAGGCCGAGACCGCACCCACTGGCTGTATCTCGCGGTCATTTTCGCAGTGATAGCCGGTGTGATCGTGGGGCTGACGGCGCCGTCGACCGGAAAAAGCCTCACGGTGCTCGGGACGGTGTTCGTCAACCTGATCAAGATGATGATCGCACCGGTCATCTTCTGCACGATCGTGCTCGGGATCGGCTCGGTGCGCAAAGCCGCGGCCGTGGGCAAGGTCGGCGGGCTGGCTTTGGCCTACTTTCTAACGATGTCATCGGTGGCGCTCGGGATCGGGTTGATCGTCGGCAACCTACTCAGTCCGGGTAGGGATCTGCACCTTAGGCCTGGTGCGGTCGGAAGCGGCGCAGCATTGGCCGGCCAGGCTGCGGAGTCACACGGAATCGCTGGGTTCATCCAGCAGATCATTCCGAGGTCGCTCCCCTCAGCCCTTACTGAAGGCAACGTGCTGCAGGTGTTACTCGTCGCGCTGCTGGTCGGTTTCGCGGTCCAAGGCCTGGGCCCCGCAGGCGAGTCCATCCTGCGTGCCGTCGAGAACCTGCAAAAGCTGGTGTTCAAGGTGCTCGTGATGGTACTGTGGCTGGCTCCGATCGGCGCGTTCGGTGCGATCGCCAATATCGTCGCCACGACTGGCTTCAACGCCGTCACCAACCTGCTGCTGCTGATGGCCGGCTTCTACCTGACGTGCGTGGTGTTCGTTTTCGGCGTCCTGGGAGTGCTACTGCGCATCGTGTCGGGTTTGTCGATCTTTCGGCTGCTGCGCTATCTAGCCCGCGAGTACTTGCTGATCTTCGCAACATCGTCGTCGGAGGTGGTGCTGCCCAGACTGATCACCAAGATGAAACACTTGGGCGTGCAATCCAGCACGGTCGGCGTGGTGGTGCCGACCGGCTACTCGTTCAATCTTGACGGCACCGCTATCTATCTGACCATGGCGTCGCTGTTCATCGCCGACGCGATGGGACATCGCTTGACATGGGGCGAGCAGATCGCGCTGCTGGCGTTCATGATCATCGCGTCCAAGGGCGCTGCCGGGGTCAGCGGTGCGGGCCTTGCGACGCTGGCCGGCGGCCTGCAGGCTCATCGCCCCGAGCTGCTGGACGGTGTCGGGCTGATTGTGGGGATCGACCGGTTCATGTCGGAAGCCCGTTCGCTCACGAACTTCTCCGGCAACGCCGTCGCAACCATCCTGGTTGCCTCGTGGACAAAGACCATTGACCTGTCCAAAGCCGACGAGGTGTTGCGCGGTCGTGATCCCTTCGACGAATCGACCATGGTCGATCCCCACGATGAGGAGCCACCCGCCGCCACACCCCACGGGGGCGGCGTCCCGACGAACCCTGCGCTGTGCGATTTCGAGCAGGTCAGTCTAGGCGGATTGGTGGGCCGGCCGGCCGGCCCGCAACGCGCCGACGTGGACGGGTAG
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Unknown

Family

Dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family

GO

transmembrane transporter activity GO:0022857 molecular_function
malate:proton symporter activity GO:0015366 molecular_function
extracellular region GO:0005576 cellular_component
L-aspartate transmembrane transport GO:0070778 biological_process
plasma membrane GO:0005886 cellular_component
fumarate transmembrane transporter activity GO:0015138 molecular_function
succinate transmembrane transporter activity GO:0015141 molecular_function
integral component of membrane GO:0016021 cellular_component

InterPro

UniProt: P71906
GenBank: Rv2443
EnsemblBacteria: Rv2443
Mycobrowser: Rv2443

Summary

Name: Probable C4-dicarboxylate-transport transmembrane protein DctA
Family: Dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family
Protein Sequence: MTAPLDRAPVTDLPANNKGRDRTHWLYLAVIFAVIAGVIVGLTAPSTGKSLTVLGTVFVNLIKMMIAPVIFCTIVLGIGSVRKAAAVGKVGGLALAYFLTMSSVALGIGLIVGNLLSPGRDLHLRPGAVGSGAALAGQAAESHGIAGFIQQIIPRSLPSALTEGNVLQVLLVALLVGFAVQGLGPAGESILRAVENLQKLVFKVLVMVLWLAPIGAFGAIANIVATTGFNAVTNLLLLMAGFYLTCVVFVFGVLGVLLRIVSGLSIFRLLRYLAREYLLIFATSSSEVVLPRLITKMKHLGVQSSTVGVVVPTGYSFNLDGTAIYLTMASLFIADAMGHRLTWGEQIALLAFMIIASKGAAGVSGAGLATLAGGLQAHRPELLDGVGLIVGIDRFMSEARSLTNFSGNAVATILVASWTKTIDLSKADEVLRGRDPFDESTMVDPHDEEPPAATPHGGGVPTNPALCDFEQVSLGGLVGRPAGPQRADVDG
Mass: 50,988 Da
Length: 491 Aa

Rv2443 doesn't seem to be a targeted by any drug.

Two-component system mtu02020
mtu02020
Environmental Information Processing; Signal transduction

Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.