tig
- Type
- protein_coding
- Name
- tig
- Locus Name
-
Rv2462c
- Product
-
Probable trigger factor (TF) protein Tig
- Functional Category
-
Cell wall and cell processes
- Location
- 2763891..2765291 (- strand)
- Gene Length
- 1400 bp
- Nucleotides
-
GTGAAGAGCACCGTCGAGCAGTTGAGCCCCACCCGGGTTCGTATCAACGTGGAGGTGCCATTCGCCGAGCTTGAGCCGGATTTCCAGCGGGCCTACAAAGAGCTGGCCAAACAGGTGCGGCTGCCCGGCTTCCGGCCCGGGAAGGCGCCGGCCAAACTACTCGAAGCCCGCATCGGCCGGGAGGCCATGCTGGATCAAATCGTCAACGATGCGCTGCCCAGCCGGTACGGACAGGCGGTGGCCGAGTCGGATGTCCAACCGCTCGGCCGGCCCAACATCGAGGTGACCAAGAAGGAGTACGGCCAGGACCTGCAATTCACCGCCGAGGTCGACATCCGCCCGAAGATCAGTCCCCCGGACCTGAGCGCGCTGACGGTCTCGGTGGATCCGATCGAAATCGGTGAGGACGACGTCGACGCCGAACTGCAGTCGTTACGTACCCGGTTCGGCACCCTGACCGCGGTGGACCGGCCGGTGGCCGTCGGCGACGTCGTCTCGATCGACTTGTCTGCCACGGTCGACGGAGAGGACATACCGAACGCAGCCGCTGAGGGACTCTCCCACGAGGTCGGCTCCGGCCGGCTCATCGCAGGTCTCGACGACGCGGTTGTTGGTCTGTCCGCCGACGAGTCCCGGGTCTTCACCGCCAAGCTGGCAGCCGGCGAGCACGCCGGGCAGGAAGCTCAGGTTACCGTCACGGTCAGGTCGGTTAAGGAGCGCGAACTACCAGAGCCCGACGACGAATTCGCGCAGTTAGCCAGCGAGTTCGACAGCATCGACGAATTGCGGGCCAGCCTCAGCGACCAGGTGCGCCAGGCCAAGCGCGCCCAGCAGGCCGAGCAGATTCGAAACGCCACCATCGATGCGCTACTCGAACAGGTCGACGTGCCGTTGCCGGAGTCGTATGTGCAGGCCCAATTCGACAGCGTGCTGCACAGCGCGCTCAGCGGTCTTAATCACGACGAAGCCCGGTTCAATGAGTTGCTCGTCGAGCAAGGCTCGTCACGCGCGGCGTTCGATGCCGAGGCGCGCACCGCCTCAGAAAAGGACGTCAAGAGGCAGCTGTTGCTAGACGCCCTGGCCGATGAGCTGCAGGTCCAAGTTGGCCAGGATGATCTGACCGAACGACTGGTGACGACGTCTCGGCAATACGGCATCGAGCCGCAGCAGCTGTTCGGCTACCTCCAAGAGCGCAACCAGCTGCCGACCATGTTCGCTGACGTGCGGCGCGAGCTGGCGATCAGGGCCGCAGTGGAGGCGGCGACGGTCACCGACAGTGACGGAAACACGATCGATACCAGTGAGTTCTTCGGCAAGCGTGTGTCGGCCGGTGAGGCTGAGGAGGCCGAACCGGCAGACGAGGGTGCCGCGCGGGCGGCGTCCGACGAAGCGACAACGTG
- Drug Resistance
- Mutations
- Function
- Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase (By similarity). {ECO:0000250}.
- Family
-
FKBP-type PPIase family, Tig subfamily
- GO
-
- protein folding chaperone GO:0044183 molecular_function
- response to antibiotic GO:0046677 biological_process
- cell cycle GO:0007049 biological_process
- 'de novo' cotranslational protein folding GO:0051083 biological_process
- chaperone-mediated protein folding GO:0061077 biological_process
- protein unfolding GO:0043335 biological_process
- cell division GO:0051301 biological_process
- plasma membrane GO:0005886 cellular_component
- cytosol GO:0005829 cellular_component
- cell wall GO:0005618 cellular_component
- protein transport GO:0015031 biological_process
- ribosome binding GO:0043022 molecular_function
- peptidyl-prolyl cis-trans isomerase activity GO:0003755 molecular_function
- cellular response to starvation GO:0009267 biological_process
- InterPro
Summary
- Name
- Trigger factor (TF) (EC 5.2.1.8) (PPIase)
- Family
- FKBP-type PPIase family, Tig subfamily
- Protein Sequence
-
MKSTVEQLSPTRVRINVEVPFAELEPDFQRAYKELAKQVRLPGFRPGKAPAKLLEARIGREAMLDQIVNDALPSRYGQAVAESDVQPLGRPNIEVTKKEYGQDLQFTAEVDIRPKISPPDLSALTVSVDPIEIGEDDVDAELQSLRTRFGTLTAVDRPVAVGDVVSIDLSATVDGEDIPNAAAEGLSHEVGSGRLIAGLDDAVVGLSADESRVFTAKLAAGEHAGQEAQVTVTVRSVKERELPEPDDEFAQLASEFDSIDELRASLSDQVRQAKRAQQAEQIRNATIDALLEQVDVPLPESYVQAQFDSVLHSALSGLNHDEARFNELLVEQGSSRAAFDAEARTASEKDVKRQLLLDALADELQVQVGQDDLTERLVTTSRQYGIEPQQLFGYLQERNQLPTMFADVRRELAIRAAVEAATVTDSDGNTIDTSEFFGKRVSAGEAEEAEPADEGAARAASDEATT
- Mass
- 50,616 Da
- Length
- 466 Aa
Rv2462c doesn't seem to be a targeted by any drug.
Rv2462c doesn't seem to be involved in any pathway.
- Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
- Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.