Rv2477c
- Type
- protein_coding
- Name
- Rv2477c
- Locus Name
-
Rv2477c
- Product
-
Probable macrolide-transport ATP-binding protein ABC transporter
- Functional Category
-
Cell wall and cell processes
- Location
- 2782366..2784042 (- strand)
- Gene Length
- 1676 bp
- Nucleotides
-
ATGGCTGAGTTCATCTACACGATGAAGAAGGTCCGCAAGGCGCACGGCGATAAGGTGATCCTCGACGACGTGACGTTGAGTTTCTATCCGGGCGCCAAGATCGGTGTCGTCGGCCCCAACGGGGCCGGTAAGTCGAGCGTCTTGCGGATCATGGCCGGTTTGGACAAGCCGAACAACGGCGATGCCTTCCTGGCCACCGGCGCCACCGTGGGCATCCTGCAACAGGAACCGCCGCTGAACGAGGACAAGACCGTTCGCGGCAATGTGGAAGAGGGCATGGGGGACATCAAGATCAAGCTCGACCGCTTCAACGAGGTCGCCGAATTGATGGCCACCGACTACACCGACGAGCTGATGGAAGAGATGGGTCGGCTGCAAGAGGAACTGGACCACGCCGACGCGTGGGACCTCGACGCGCAGCTCGAGCAGGCCATGGATGCGCTGCGCTGTCCGCCGGCCGACGAGCCGGTAACCAACCTATCCGGTGGCGAGCGTCGCCGGGTGGCGCTGTGCAAACTGCTGTTGTCCAAACCCGACCTGTTGTTGCTCGACGAGCCGACCAACCACCTAGACGCGGAAAGTGTGCAGTGGCTCGAACAGCATCTGGCCAGCTACCCCGGTGCGATCCTGGCGGTCACCCACGACCGTTACTTCCTGGACAACGTCGCGGAATGGATCCTGGAGCTCGATCGTGGCCGCGCCTACCCCTATGAGGGCAACTACTCGACCTATCTGGAGAAAAAAGCCGAGCGGCTCGCGGTGCAAGGCCGCAAGGACGCGAAGCTGCAAAAGCGGTTGACCGAGGAGTTGGCTTGGGTCCGGTCCGGGGCCAAGGCGCGCCAGGCCAAAAGCAAGGCGCGCCTGCAGCGCTACGAGGAGATGGCAGCCGAGGCGGAGAAGACCCGCAAGCTCGACTTCGAGGAGATTCAGATCCCGGTCGGGCCCCGCCTAGGCAACGTGGTGGTTGAGGTCGACCACCTCGATAAGGGCTACGACGGGCGCGCCCTGATCAAGGACCTGTCGTTCAGCTTGCCCCGCAATGGCATCGTCGGCGTCATTGGGCCCAACGGGGTAGGCAAGACCACACTGTTCAAAACCATCGTCGGGCTCGAGACACCGGACAGCGGCAGCGTCAAGGTCGGCGAGACCGTCAAGCTGAGTTACGTGGACCAGGCCCGTGCTGGCATCGATCCGCGGAAGACCGTCTGGGAGGTTGTCTCGGACGGTCTGGACTATATCCAGGTCGGTCAAACCGAAGTGCCGTCACGGGCCTACGTGTCGGCATTCGGGTTTAAGGGACCGGACCAGCAAAAACCGGCCGGTGTGCTATCCGGCGGGGAGCGCAACAGGCTCAACCTTGCGTTGACGCTCAAACAGGGCGGCAACCTGATTCTGCTCGACGAACCGACGAACGACCTGGATGTCGAGACTCTGGGTTCGCTGGAGAATGCTCTGCTGAACTTCCCCGGCTGCGCCGTGGTGATTTCGCACGATCGCTGGTTTCTTGACCGCACGTGCACGCACATCCTGGCGTGGGAGGGTGACGACGACAACGAGGCGAAGTGGTTCTGGTTCGAGGGCAACTTCGGCGCCTACGAGGAGAACAAGGTGGAACGGCTCGGTGTCGACGCCGCTCGACCGCATAGGGTCACCCACCGCAAGCTGACGCGCGGCTA
- Drug Resistance
- Mutations
- Function
- A translation factor that gates the progression of the 70S ribosomal initiation complex (IC, containing tRNA(fMet) in the P site) into the translation elongation cycle by using a mechanism sensitive to the ATP/ADP ratio. Binds to the 70S ribosome E site where it modulates the state of the translating ribosome during subunit translocation (By similarity). {ECO:0000250}.
- Family
-
ABC transporter superfamily, ABCF family, Translational throttle EttA subfamily
- GO
-
- rRNA binding GO:0019843 molecular_function
- cell wall GO:0005618 cellular_component
- ATP binding GO:0005524 molecular_function
- cytosol GO:0005829 cellular_component
- negative regulation of translational elongation GO:0045900 biological_process
- plasma membrane GO:0005886 cellular_component
- ATPase activity GO:0016887 molecular_function
- translation GO:0006412 biological_process
- tRNA binding GO:0000049 molecular_function
- InterPro
Summary
- Name
- Energy-dependent translational throttle protein EttA (Translational regulatory factor EttA)
- Family
- ABC transporter superfamily, ABCF family, Translational throttle EttA subfamily
- Protein Sequence
-
MAEFIYTMKKVRKAHGDKVILDDVTLSFYPGAKIGVVGPNGAGKSSVLRIMAGLDKPNNGDAFLATGATVGILQQEPPLNEDKTVRGNVEEGMGDIKIKLDRFNEVAELMATDYTDELMEEMGRLQEELDHADAWDLDAQLEQAMDALRCPPADEPVTNLSGGERRRVALCKLLLSKPDLLLLDEPTNHLDAESVQWLEQHLASYPGAILAVTHDRYFLDNVAEWILELDRGRAYPYEGNYSTYLEKKAERLAVQGRKDAKLQKRLTEELAWVRSGAKARQAKSKARLQRYEEMAAEAEKTRKLDFEEIQIPVGPRLGNVVVEVDHLDKGYDGRALIKDLSFSLPRNGIVGVIGPNGVGKTTLFKTIVGLETPDSGSVKVGETVKLSYVDQARAGIDPRKTVWEVVSDGLDYIQVGQTEVPSRAYVSAFGFKGPDQQKPAGVLSGGERNRLNLALTLKQGGNLILLDEPTNDLDVETLGSLENALLNFPGCAVVISHDRWFLDRTCTHILAWEGDDDNEAKWFWFEGNFGAYEENKVERLGVDAARPHRVTHRKLTRG
- Mass
- 61,893 Da
- Length
- 558 Aa
Rv2477c doesn't seem to be a targeted by any drug.
Rv2477c doesn't seem to be involved in any pathway.
- Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
- Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
- Prokaryotic ubiquitin-like protein (Pup) proteome of Mycobacterium tuberculosis [corrected] .
- PLoS One. 2010 Jan 6;5(1):e8589. doi: 10.1371/journal.pone.0008589.
- Microarray analysis of efflux pump genes in multidrug-resistant Mycobacterium tuberculosis during stress induced by common anti-tuberculous drugs.
- Microb Drug Resist. 2010 Mar;16(1):21-8. doi: 10.1089/mdr.2009.0054.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.