Gene - combatTB X

plsC

Type: protein_coding
Name: plsC
Locus Name: Rv2483c
Product: Possible transmembrane phospholipid biosynthesis bifunctional enzyme PlsC: putative L-3-phosphoserine phosphatase (O-phosphoserine phosphohydrolase) (PSP) (pspase) + 1-acyl-SN-glycerol-3-phosphate acyltransferase (1-AGP acyltransferase) (1-AGPAT) (lysophosphatidic acid acyltransferase) (LPAAT)
Functional Category: Lipid metabolism
Location: 2789280..2791022 (- strand)
Gene Length: 1742 bp
Nucleotides: ATGAGCGCCGCTGACGAGCAGGGGGAAGAGCGGGCGACGCGGAAGTCGGCGCCGGATTTGCGCCTACCCGGTTCGGTAGCCGAGATTCTGGCCAGTCCTGCCGGCCCGAAGGTCGGTGCGTTTTTCGACCTGGACGGCACGCTGGTCGCCGGCTTCACGGCCGTCATCCTCACCCAGGAGAGGCTGCGGCGCCGCGATATGGGCGTGGGCGAGCTGCTCGGTATGGTTCAGGCCGGCCTGAATCACACGCTCGGGCGAATCGAGTTCGAAGACCTTATCGGAAAGGCCGCCGCGGCGCTGGCCGGGCGGCTCTTGACCGACCTGGAAGAAATCGGCGAGCGGCTATTCGCCCAGCGGATCGAGTCCCGGATCTACCCGGAAATGCGGGAACTGGTCCGGGCTCACGTGGCCCGCGGCCACACCGTGGTCCTCAGCTCGTCGGCGCTGACCATCCAAGTTGGCCCAGTCGCACGTTTTCTGGGGATCAACAACATGCTCACCAACAAGTTCGAGACCAACGAGGACGGGATACTCACCGGGGGTGTGCTGAAGCCAATTTTGTGGTGTCCGGGCAAAGCCACTGCGGTGCAACGCTTTGCGGCCGAGCACGACATCGATCTCAAAGACAGTTACTTCTATGCCGACGGTGACGAGGACGTCGCCCTGATGTATCTGGTGGGCAATCCGCGACCGACCAATCCGGAAGGAAAGATGGCCGCGGTCGCCAAGCGACGGGGCTGGCCGATCTTGAAGTTCAACAGTCGCGGCGGTGTGGGCATCCGGCGGCAGTTGCGGACACTTGCCGGTCTGAGCACCATCGTCCCGGTCGCGGCCGGCGCGGTAGGGATCGGTGTGCTGACCGGTAGCCGGCGCCGCGGCGTGAATTTCTTTACCTCCACCTTCTCTCAGCTGCTGCTGGCGACCAGCGGCGTGCACCTGAATGTGATCGGAAAAGAGAATCTGACCGCCCAGCGGCCCGCCGTCTTTATCTTCAACCACCGCAACCAGGTTGACCCGGTCATTGCCGGTGCGCTGGTGCGCGACAACTGGGTTGGGGTGGGCAAGAAGGAACTGGCGAGCGACCCGATCATGGGCACGCTGGGGAAGTTGCTGGACGGTGTGTTCATCGACCGTGATGATCCGGTCGCCGCGGTGGAGACACTGCACACGGTTGAGGAGCGCGCCCGCAATGGACTATCGATCGTGATCGCTCCCGAAGGTACCCGGTTGGATACCACCGAAGTCGGGTCATTCAAGAAGGGGCCCTTCCGTATCGCCATGGCCGCGAAGATCCCGATCGTGCCGATCGTGATCCGCAATGCGGAGATCGTCGCCTCGCGCAACTCCACCACGATCAATCCGGGCACGGTCGACGTCGCGGTGTTTCCGCCGATTCCGGTCGATGACTGGACCCTGGACGCCCTGCCGGATCGTATCGCCGAGGTGCGCCAGCTGTATCTGGACACGCTGGCGGACTGGCCGGTCGATGGGTTGCCCGCGGTCGATCTGTACGCCGAGCAGAAGGCCGCCAGAAAAGCCAGGGCTCAGGTCGCCAAGGCCACCGCGAAAAGGGTGCCGGCTAAGAAGGCTCCCGCCAAAAGCGCCGCCAATAAAGGCGCGGCCGCGACGAAGGCGGCTACAAAGAAGGCATCGCCGAAGGCCAAACCCAGCGAATCTAAGATCGCTGGCAAGGATGGTGAGGCCTCCGCATCGCCAAGCTCTAGCGCCAAAGGACGGTCGTG
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Unknown

Family

Unknown

GO

1-acylglycerol-3-phosphate O-acyltransferase activity GO:0003841 molecular_function
plasma membrane GO:0005886 cellular_component
phosphatidic acid biosynthetic process GO:0006654 biological_process

InterPro

UniProt: I6YDI9
GenBank: Rv2483c
EnsemblBacteria: Rv2483c
Mycobrowser: Rv2483c

Summary

Name: Uncharacterized protein
Family: Unknown
Protein Sequence: MSAADEQGEERATRKSAPDLRLPGSVAEILASPAGPKVGAFFDLDGTLVAGFTAVILTQERLRRRDMGVGELLGMVQAGLNHTLGRIEFEDLIGKAAAALAGRLLTDLEEIGERLFAQRIESRIYPEMRELVRAHVARGHTVVLSSSALTIQVGPVARFLGINNMLTNKFETNEDGILTGGVLKPILWCPGKATAVQRFAAEHDIDLKDSYFYADGDEDVALMYLVGNPRPTNPEGKMAAVAKRRGWPILKFNSRGGVGIRRQLRTLAGLSTIVPVAAGAVGIGVLTGSRRRGVNFFTSTFSQLLLATSGVHLNVIGKENLTAQRPAVFIFNHRNQVDPVIAGALVRDNWVGVGKKELASDPIMGTLGKLLDGVFIDRDDPVAAVETLHTVEERARNGLSIVIAPEGTRLDTTEVGSFKKGPFRIAMAAKIPIVPIVIRNAEIVASRNSTTINPGTVDVAVFPPIPVDDWTLDALPDRIAEVRQLYLDTLADWPVDGLPAVDLYAEQKAARKARAQVAKATAKRVPAKKAPAKSAANKGAAATKAATKKASPKAKPSESKIAGKDGEASASPSSSAKGRS
Mass: 61,788 Da
Length: 580 Aa

Rv2483c doesn't seem to be a targeted by any drug.

Rv2483c doesn't seem to be involved in any pathway.

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.